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Items: 1 to 20 of 117

1.

Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.

Feng J, Park J, Cron P, Hess D, Hemmings BA.

J Biol Chem. 2004 Sep 24;279(39):41189-96. Epub 2004 Jul 15.

2.

Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase.

Hill MM, Andjelkovic M, Brazil DP, Ferrari S, Fabbro D, Hemmings BA.

J Biol Chem. 2001 Jul 13;276(28):25643-6. Epub 2001 May 23.

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Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation.

Troussard AA, Mawji NM, Ong C, Mui A, St -Arnaud R, Dedhar S.

J Biol Chem. 2003 Jun 20;278(25):22374-8. Epub 2003 Apr 8.

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.

Hresko RC, Mueckler M.

J Biol Chem. 2005 Dec 9;280(49):40406-16. Epub 2005 Oct 11.

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DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.

Park J, Feng J, Li Y, Hammarsten O, Brazil DP, Hemmings BA.

J Biol Chem. 2009 Mar 6;284(10):6169-74. doi: 10.1074/jbc.C800210200. Epub 2009 Jan 14.

9.

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

Berwick DC, Dell GC, Welsh GI, Heesom KJ, Hers I, Fletcher LM, Cooke FT, Tavaré JM.

J Cell Sci. 2004 Dec 1;117(Pt 25):5985-93. Epub 2004 Nov 16.

10.

Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulates IRS-1 function.

Paz K, Liu YF, Shorer H, Hemi R, LeRoith D, Quan M, Kanety H, Seger R, Zick Y.

J Biol Chem. 1999 Oct 1;274(40):28816-22.

11.

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

Stratford S, Hoehn KL, Liu F, Summers SA.

J Biol Chem. 2004 Aug 27;279(35):36608-15. Epub 2004 Jun 25.

12.

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

Viniegra JG, Martínez N, Modirassari P, Hernández Losa J, Parada Cobo C, Sánchez-Arévalo Lobo VJ, Aceves Luquero CI, Alvarez-Vallina L, Ramón y Cajal S, Rojas JM, Sánchez-Prieto R.

J Biol Chem. 2005 Feb 11;280(6):4029-36. Epub 2004 Nov 15.

13.

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.

Surucu B, Bozulic L, Hynx D, Parcellier A, Hemmings BA.

J Biol Chem. 2008 Oct 31;283(44):30025-33. doi: 10.1074/jbc.M803053200. Epub 2008 Aug 29.

14.

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane.

Maira SM, Galetic I, Brazil DP, Kaech S, Ingley E, Thelen M, Hemmings BA.

Science. 2001 Oct 12;294(5541):374-80.

15.

Identification of 14-3-3zeta as a protein kinase B/Akt substrate.

Powell DW, Rane MJ, Chen Q, Singh S, McLeish KR.

J Biol Chem. 2002 Jun 14;277(24):21639-42. Epub 2002 Apr 15.

16.

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

Scheid MP, Marignani PA, Woodgett JR.

Mol Cell Biol. 2002 Sep;22(17):6247-60.

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Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.

Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1385-94.

20.

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