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Items: 1 to 20 of 95

1.

Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.

Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS.

Nat Med. 2004 Jul;10(7):734-8. Epub 2004 Jun 27.

PMID:
15220914
2.

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity.

Mori H, Hanada R, Hanada T, Aki D, Mashima R, Nishinakamura H, Torisu T, Chien KR, Yasukawa H, Yoshimura A.

Nat Med. 2004 Jul;10(7):739-43. Epub 2004 Jun 20.

PMID:
15208705
3.

Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

Reed AS, Unger EK, Olofsson LE, Piper ML, Myers MG Jr, Xu AW.

Diabetes. 2010 Apr;59(4):894-906. doi: 10.2337/db09-1024. Epub 2010 Jan 12.

4.

Lentiviral vector-mediated knockdown of SOCS3 in the hypothalamus protects against the development of diet-induced obesity in rats.

Liu ZJ, Bian J, Zhao YL, Zhang X, Zou N, Li D.

Diabetes Obes Metab. 2011 Oct;13(10):885-92. doi: 10.1111/j.1463-1326.2011.01419.x.

PMID:
21554522
5.

Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight.

Zhang R, Dhillon H, Yin H, Yoshimura A, Lowell BB, Maratos-Flier E, Flier JS.

Endocrinology. 2008 Nov;149(11):5654-61. doi: 10.1210/en.2008-0805. Epub 2008 Jul 31.

6.

Feedback inhibition of leptin receptor/Jak2 signaling via Tyr1138 of the leptin receptor and suppressor of cytokine signaling 3.

Dunn SL, Björnholm M, Bates SH, Chen Z, Seifert M, Myers MG Jr.

Mol Endocrinol. 2005 Apr;19(4):925-38. Epub 2004 Dec 16.

PMID:
15604114
7.

Signaling through Tyr985 of leptin receptor as an age/diet-dependent switch in the regulation of energy balance.

You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G, Ke Z, Li W, Li C, Liu Y.

Mol Cell Biol. 2010 Apr;30(7):1650-9. doi: 10.1128/MCB.01307-09. Epub 2010 Jan 19.

8.

SOCS3 expression within leptin receptor-expressing cells regulates food intake and leptin sensitivity but does not affect weight gain in pregnant mice consuming a high-fat diet.

Zampieri TT, da Silva TE, de Paula Romeu D, Torrão AS, Donato J Jr.

Physiol Behav. 2016 Apr 1;157:109-15. doi: 10.1016/j.physbeh.2016.01.039. Epub 2016 Jan 28.

PMID:
26828039
9.

Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet.

McEwen HJ, Inglis MA, Quennell JH, Grattan DR, Anderson GM.

J Neurosci. 2016 Jul 6;36(27):7142-53. doi: 10.1523/JNEUROSCI.2714-14.2016.

10.

Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling.

Matarazzo V, Schaller F, Nédélec E, Benani A, Pénicaud L, Muscatelli F, Moyse E, Bauer S.

J Neurosci. 2012 Nov 28;32(48):17097-107. doi: 10.1523/JNEUROSCI.1669-12.2012.

11.

Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity.

Sachithanandan N, Fam BC, Fynch S, Dzamko N, Watt MJ, Wormald S, Honeyman J, Galic S, Proietto J, Andrikopoulos S, Hevener AL, Kay TW, Steinberg GR.

Hepatology. 2010 Nov;52(5):1632-42. doi: 10.1002/hep.23861.

PMID:
20799351
12.

Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).

Yang Z, Hulver M, McMillan RP, Cai L, Kershaw EE, Yu L, Xue B, Shi H.

PLoS One. 2012;7(10):e47493. doi: 10.1371/journal.pone.0047493. Epub 2012 Oct 24.

13.

CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity.

Ravinet Trillou C, Delgorge C, Menet C, Arnone M, Soubrié P.

Int J Obes Relat Metab Disord. 2004 Apr;28(4):640-8.

PMID:
14770190
14.

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance.

Olofsson LE, Unger EK, Cheung CC, Xu AW.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E697-706. doi: 10.1073/pnas.1218284110. Epub 2013 Feb 5.

15.

Dietary-induced obesity and hypothalamic infertility in female DBA/2J mice.

Tortoriello DV, McMinn J, Chua SC.

Endocrinology. 2004 Mar;145(3):1238-47. Epub 2003 Dec 11.

PMID:
14670988
16.

Molecular and anatomical determinants of central leptin resistance.

Münzberg H, Myers MG Jr.

Nat Neurosci. 2005 May;8(5):566-70. Review.

PMID:
15856064
17.

SOCS3 ablation in SF1 cells causes modest metabolic effects during pregnancy and lactation.

Ramos-Lobo AM, Teixeira PDS, Furigo IC, Donato J Jr.

Neuroscience. 2017 Dec 4;365:114-124. doi: 10.1016/j.neuroscience.2017.09.048. Epub 2017 Oct 5.

PMID:
28987511
18.

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.

Jorgensen SB, O'Neill HM, Sylow L, Honeyman J, Hewitt KA, Palanivel R, Fullerton MD, Öberg L, Balendran A, Galic S, van der Poel C, Trounce IA, Lynch GS, Schertzer JD, Steinberg GR.

Diabetes. 2013 Jan;62(1):56-64. doi: 10.2337/db12-0443. Epub 2012 Sep 6.

19.

Leptin signaling in the hypothalamus during chronic central leptin infusion.

Pal R, Sahu A.

Endocrinology. 2003 Sep;144(9):3789-98.

PMID:
12933650
20.

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