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Items: 1 to 20 of 287

1.

Total synthesis and anti-tubulin activity of epi-c3 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI.

J Med Chem. 2004 Jul 1;47(14):3697-9.

PMID:
15214797
2.

Total synthesis and antitubulin activity of c10 analogues of cryptophycin-24.

Buck SB, Huff JK, Himes RH, Georg GI.

J Med Chem. 2004 Jan 29;47(3):696-702.

PMID:
14736249
3.

Halohydrin analogues of cryptophycin 1: synthesis and biological activity.

Georg GI, Ali SM, Stella VJ, Waugh WN, Himes RH.

Bioorg Med Chem Lett. 1998 Aug 4;8(15):1959-62.

PMID:
9873466
4.

Cryptophycin affinity labels: synthesis and biological activity of a benzophenone analogue of cryptophycin-24.

Vidya R, Eggen M, Georg GI, Himes RH.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):757-60.

PMID:
12639575
5.

First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues.

Smith AB 3rd, Cho YS, Zawacki LE, Hirschmann R, Pettit GR.

Org Lett. 2001 Dec 13;3(25):4063-6.

PMID:
11735585
6.

Synthesis and biological evaluation of cryptophycin analogs with substitution at C-6 (fragment C region).

Varie DL, Shih C, Hay DA, Andis SL, Corbett TH, Gossett LS, Janisse SK, Martinelli MJ, Moher ED, Schultz RM, Toth JE.

Bioorg Med Chem Lett. 1999 Feb 8;9(3):369-74.

PMID:
10091686
7.

Novel cryptophycin antitumor agents: synthesis and cytotoxicity of fragment "B" analogues.

Patel VF, Andis SL, Kennedy JH, Ray JE, Schultz RM.

J Med Chem. 1999 Jul 15;42(14):2588-603.

PMID:
10411479
8.
9.

Total syntheses and biological investigations of tamandarins A and B and tamandarin A analogs.

Liang B, Richard DJ, Portonovo PS, Joullié MM.

J Am Chem Soc. 2001 May 16;123(19):4469-74.

PMID:
11457232
10.

Cryptophycins-309, 249 and other cryptophycin analogs: preclinical efficacy studies with mouse and human tumors.

Liang J, Moore RE, Moher ED, Munroe JE, Al-awar RS, Hay DA, Varie DL, Zhang TY, Aikins JA, Martinelli MJ, Shih C, Ray JE, Gibson LL, Vasudevan V, Polin L, White K, Kushner J, Simpson C, Pugh S, Corbett TH.

Invest New Drugs. 2005 Jun;23(3):213-24.

PMID:
15868377
11.

Structure--activity relationships of side-chain modified didemnins.

Ding X, Vera MD, Liang B, Zhao Y, Leonard MS, Joullié MM.

Bioorg Med Chem Lett. 2001 Jan 22;11(2):231-4.

PMID:
11206466
12.

Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region.

Shih C, Gossett LS, Gruber JM, Grossman CS, Andis SL, Schultz RM, Worzalla JF, Corbett TH, Metz JT.

Bioorg Med Chem Lett. 1999 Jan 4;9(1):69-74.

PMID:
9990459
13.

Synthesis, conformational analysis, and cytotoxicity of new analogues of the natural cyclodepsipeptide jaspamide.

Terracciano S, Bruno I, Bifulco G, Copper JE, Smith CD, Gomez-Paloma L, Riccio R.

J Nat Prod. 2004 Aug;67(8):1325-31.

PMID:
15332850
14.

Biological evaluation of cryptophycin 52 fragment A analogues: effect of the multidrug resistance ATP binding cassette transporters on antitumor activity.

Al-Awar RS, Corbett TH, Ray JE, Polin L, Kennedy JH, Wagner MM, Williams DC.

Mol Cancer Ther. 2004 Sep;3(9):1061-7.

15.

6-Alkylamino- and 2,3-dihydro-3'-methoxy-2-phenyl-4-quinazolinones and related compounds: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.

Hour MJ, Huang LJ, Kuo SC, Xia Y, Bastow K, Nakanishi Y, Hamel E, Lee KH.

J Med Chem. 2000 Nov 16;43(23):4479-87.

PMID:
11087572
16.

Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.

Reddy MV, Mallireddigari MR, Cosenza SC, Pallela VR, Iqbal NM, Robell KA, Kang AD, Reddy EP.

J Med Chem. 2008 Jan 10;51(1):86-100. Epub 2007 Dec 19.

PMID:
18088089
17.

Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity.

Narita K, Kikuchi T, Watanabe K, Takizawa T, Oguchi T, Kudo K, Matsuhara K, Abe H, Yamori T, Yoshida M, Katoh T.

Chemistry. 2009 Oct 26;15(42):11174-86. doi: 10.1002/chem.200901552.

PMID:
19760730
18.

A convergent approach to cryptophycin 52 analogues: synthesis and biological evaluation of a novel series of fragment a epoxides and chlorohydrins.

Al-Awar RS, Ray JE, Schultz RM, Andis SL, Kennedy JH, Moore RE, Liang J, Golakoti T, Subbaraju GV, Corbett TH.

J Med Chem. 2003 Jul 3;46(14):2985-3007.

PMID:
12825938
19.

Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.

Edsall AB, Mohanakrishnan AK, Yang D, Fanwick PE, Hamel E, Hanson AD, Agoston GE, Cushman M.

J Med Chem. 2004 Oct 7;47(21):5126-39.

PMID:
15456256
20.

Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.

Prinz H, Ishii Y, Hirano T, Stoiber T, Camacho Gomez JA, Schmidt P, Düssmann H, Burger AM, Prehn JH, Günther EG, Unger E, Umezawa K.

J Med Chem. 2003 Jul 17;46(15):3382-94.

PMID:
12852768

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