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Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor.

Michels AA, Fraldi A, Li Q, Adamson TE, Bonnet F, Nguyen VT, Sedore SC, Price JP, Price DH, Lania L, Bensaude O.

EMBO J. 2004 Jul 7;23(13):2608-19. Epub 2004 Jun 17.


MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner.

Michels AA, Nguyen VT, Fraldi A, Labas V, Edwards M, Bonnet F, Lania L, Bensaude O.

Mol Cell Biol. 2003 Jul;23(14):4859-69. Erratum in: Mol Cell Biol. 2003 Dec;23(24):9405.


Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.

Yik JH, Chen R, Nishimura R, Jennings JL, Link AJ, Zhou Q.

Mol Cell. 2003 Oct;12(4):971-82.


Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.

Liu P, Xiang Y, Fujinaga K, Bartholomeeusen K, Nilson KA, Price DH, Peterlin BM.

J Biol Chem. 2014 Apr 4;289(14):9918-25. doi: 10.1074/jbc.M113.539015. Epub 2014 Feb 10.


Acetylation of cyclin T1 regulates the equilibrium between active and inactive P-TEFb in cells.

Cho S, Schroeder S, Kaehlcke K, Kwon HS, Pedal A, Herker E, Schnoelzer M, Ott M.

EMBO J. 2009 May 20;28(10):1407-17. doi: 10.1038/emboj.2009.99. Epub 2009 Apr 23.


Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb.

Barboric M, Kohoutek J, Price JP, Blazek D, Price DH, Peterlin BM.

EMBO J. 2005 Dec 21;24(24):4291-303. Epub 2005 Dec 15.


Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat.

Schulte A, Czudnochowski N, Barboric M, Schönichen A, Blazek D, Peterlin BM, Geyer M.

J Biol Chem. 2005 Jul 1;280(26):24968-77. Epub 2005 Apr 25.


Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb.

Blazek D, Barboric M, Kohoutek J, Oven I, Peterlin BM.

Nucleic Acids Res. 2005 Dec 23;33(22):7000-10. Print 2005.


Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.

Czudnochowski N, Vollmuth F, Baumann S, Vogel-Bachmayr K, Geyer M.

J Mol Biol. 2010 Jan 8;395(1):28-41. doi: 10.1016/j.jmb.2009.10.055. Epub 2009 Oct 31.


Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

Schröder S, Cho S, Zeng L, Zhang Q, Kaehlcke K, Mak L, Lau J, Bisgrove D, Schnölzer M, Verdin E, Zhou MM, Ott M.

J Biol Chem. 2012 Jan 6;287(2):1090-9. doi: 10.1074/jbc.M111.282855. Epub 2011 Nov 14.


HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK.

Byers SA, Price JP, Cooper JJ, Li Q, Price DH.

J Biol Chem. 2005 Apr 22;280(16):16360-7. Epub 2005 Feb 14.


Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer.

Dulac C, Michels AA, Fraldi A, Bonnet F, Nguyen VT, Napolitano G, Lania L, Bensaude O.

J Biol Chem. 2005 Aug 26;280(34):30619-29. Epub 2005 Jun 30.


Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat.

Muniz L, Egloff S, Ughy B, Jády BE, Kiss T.

PLoS Pathog. 2010 Oct 14;6(10):e1001152. doi: 10.1371/journal.ppat.1001152.

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