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Items: 1 to 20 of 370

1.

Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis.

Davis HR Jr, Zhu LJ, Hoos LM, Tetzloff G, Maguire M, Liu J, Yao X, Iyer SP, Lam MH, Lund EG, Detmers PA, Graziano MP, Altmann SW.

J Biol Chem. 2004 Aug 6;279(32):33586-92. Epub 2004 Jun 1.

2.

Sitosterol reduces messenger RNA and protein expression levels of Niemann-Pick C1-like 1 in FHs 74 Int cells.

Jesch ED, Seo JM, Carr TP, Lee JY.

Nutr Res. 2009 Dec;29(12):859-66. doi: 10.1016/j.nutres.2009.10.016.

PMID:
19963159
3.

Reduced cholesterol absorption upon PPARdelta activation coincides with decreased intestinal expression of NPC1L1.

van der Veen JN, Kruit JK, Havinga R, Baller JF, Chimini G, Lestavel S, Staels B, Groot PH, Groen AK, Kuipers F.

J Lipid Res. 2005 Mar;46(3):526-34. Epub 2004 Dec 16.

4.

Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice.

Davis HR Jr, Hoos LM, Tetzloff G, Maguire M, Zhu LJ, Graziano MP, Altmann SW.

Arterioscler Thromb Vasc Biol. 2007 Apr;27(4):841-9. Epub 2007 Jan 11.

5.

Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1).

Davis HR Jr, Basso F, Hoos LM, Tetzloff G, Lally SM, Altmann SW.

Atheroscler Suppl. 2008 Sep;9(2):77-81. doi: 10.1016/j.atherosclerosissup.2008.05.008. Epub 2008 Jun 27. Review.

PMID:
18585981
6.

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.

Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP.

Science. 2004 Feb 20;303(5661):1201-4.

7.

Disodium ascorbyl phytostanol phosphate (FM-VP4), a modified phytostanol, is a highly active hypocholesterolaemic agent that affects the enterohepatic circulation of both cholesterol and bile acids in mice.

Méndez-González J, Süren-Castillo S, Calpe-Berdiel L, Rotllan N, Vázquez-Carrera M, Escolà-Gil JC, Blanco-Vaca F.

Br J Nutr. 2010 Jan;103(2):153-60. doi: 10.1017/S0007114509991656. Epub 2009 Oct 13.

PMID:
19822032
8.

Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter.

Davis HR Jr, Altmann SW.

Biochim Biophys Acta. 2009 Jul;1791(7):679-83. doi: 10.1016/j.bbalip.2009.01.002. Epub 2009 Jan 19. Review.

PMID:
19272334
9.

Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells.

Yamanashi Y, Takada T, Suzuki H.

J Pharmacol Exp Ther. 2007 Feb;320(2):559-64. Epub 2006 Nov 29.

10.
11.

Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia.

Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA.

J Biol Chem. 2005 Apr 1;280(13):12710-20. Epub 2005 Jan 25.

12.

Changes in intestinal and liver global gene expression in response to a phytosterol-enriched diet.

Calpe-Berdiel L, Escolà-Gil JC, Ribas V, Navarro-Sastre A, Garcés-Garcés J, Blanco-Vaca F.

Atherosclerosis. 2005 Jul;181(1):75-85. Epub 2005 Feb 12.

PMID:
15939057
13.

Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8.

Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L.

J Lipid Res. 2009 Feb;50(2):293-300. doi: 10.1194/jlr.M800439-JLR200. Epub 2008 Sep 15.

14.

Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1.

Moussa M, Landrier JF, Reboul E, Ghiringhelli O, Coméra C, Collet X, Fröhlich K, Böhm V, Borel P.

J Nutr. 2008 Aug;138(8):1432-6.

15.

The structure and function of Niemann-Pick C1-like 1 protein.

Yu L.

Curr Opin Lipidol. 2008 Jun;19(3):263-9. doi: 10.1097/MOL.0b013e3282f9b563. Review. Erratum in: Curr Opin Lipidol. 2008 Aug;19(4):440.

PMID:
18460917
16.

Localization and role of NPC1L1 in cholesterol absorption in human intestine.

Sané AT, Sinnett D, Delvin E, Bendayan M, Marcil V, Ménard D, Beaulieu JF, Levy E.

J Lipid Res. 2006 Oct;47(10):2112-20. Epub 2006 Jul 7.

17.

Corn fiber oil and sitostanol decrease cholesterol absorption independently of intestinal sterol transporters in hamsters.

Jain D, Ebine N, Jia X, Kassis A, Marinangeli C, Fortin M, Beech R, Hicks KB, Moreau RA, Kubow S, Jones PJ.

J Nutr Biochem. 2008 Apr;19(4):229-36. Epub 2007 Jun 29.

PMID:
17601722
18.
19.

Niemann-pick C1-like 1 (NPC1L1) protein in intestinal and hepatic cholesterol transport.

Jia L, Betters JL, Yu L.

Annu Rev Physiol. 2011;73:239-59. doi: 10.1146/annurev-physiol-012110-142233. Review.

20.

New insights into the genetic regulation of intestinal cholesterol absorption.

Lammert F, Wang DQ.

Gastroenterology. 2005 Aug;129(2):718-34. Review.

PMID:
16083725

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