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Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization.

Dettwiler S, Aringhieri C, Cardinale S, Keller W, Barabino SM.

J Biol Chem. 2004 Aug 20;279(34):35788-97. Epub 2004 May 28.


Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.

de Vries H, Rüegsegger U, Hübner W, Friedlein A, Langen H, Keller W.

EMBO J. 2000 Nov 1;19(21):5895-904.


Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit.

Cardinale S, Cisterna B, Bonetti P, Aringhieri C, Biggiogera M, Barabino SM.

Mol Biol Cell. 2007 Apr;18(4):1282-92. Epub 2007 Jan 31.


Structural basis of pre-mRNA recognition by the human cleavage factor Im complex.

Li H, Tong S, Li X, Shi H, Ying Z, Gao Y, Ge H, Niu L, Teng M.

Cell Res. 2011 Jul;21(7):1039-51. doi: 10.1038/cr.2011.67. Epub 2011 Apr 12.


Cleavage factor Im is a key regulator of 3' UTR length.

Gruber AR, Martin G, Keller W, Zavolan M.

RNA Biol. 2012 Dec;9(12):1405-12. doi: 10.4161/rna.22570. Epub 2012 Nov 27.


The 25 kDa subunit of cleavage factor Im Is a RNA-binding protein that interacts with the poly(A) polymerase in Entamoeba histolytica.

Pezet-Valdez M, Fernández-Retana J, Ospina-Villa JD, Ramírez-Moreno ME, Orozco E, Charcas-López S, Soto-Sánchez J, Mendoza-Hernández G, López-Casamicha M, López-Camarillo C, Marchat LA.

PLoS One. 2013 Jun 28;8(6):e67977. doi: 10.1371/journal.pone.0067977. Print 2013.


An interaction between U2AF 65 and CF I(m) links the splicing and 3' end processing machineries.

Millevoi S, Loulergue C, Dettwiler S, Karaa SZ, Keller W, Antoniou M, Vagner S.

EMBO J. 2006 Oct 18;25(20):4854-64. Epub 2006 Oct 5.


Distinct roles of two Yth1p domains in 3'-end cleavage and polyadenylation of yeast pre-mRNAs.

Barabino SM, Ohnacker M, Keller W.

EMBO J. 2000 Jul 17;19(14):3778-87.


Crystal structure of the 25 kDa subunit of human cleavage factor Im.

Coseno M, Martin G, Berger C, Gilmartin G, Keller W, Doublié S.

Nucleic Acids Res. 2008 Jun;36(10):3474-83. doi: 10.1093/nar/gkn079. Epub 2008 Apr 29.


The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs.

Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D.

Nucleic Acids Res. 2010 Nov;38(21):7637-50. doi: 10.1093/nar/gkq613. Epub 2010 Jul 15.


Crystal structure of a human cleavage factor CFI(m)25/CFI(m)68/RNA complex provides an insight into poly(A) site recognition and RNA looping.

Yang Q, Coseno M, Gilmartin GM, Doublié S.

Structure. 2011 Mar 9;19(3):368-77. doi: 10.1016/j.str.2010.12.021. Epub 2011 Feb 3.


Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor.

Zhao J, Kessler M, Helmling S, O'Connor JP, Moore C.

Mol Cell Biol. 1999 Nov;19(11):7733-40.


Characterization and cloning of the human splicing factor 9G8: a novel 35 kDa factor of the serine/arginine protein family.

Cavaloc Y, Popielarz M, Fuchs JP, Gattoni R, Stévenin J.

EMBO J. 1994 Jun 1;13(11):2639-49.


Structural basis of UGUA recognition by the Nudix protein CFI(m)25 and implications for a regulatory role in mRNA 3' processing.

Yang Q, Gilmartin GM, Doublié S.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10062-7. doi: 10.1073/pnas.1000848107. Epub 2010 May 17.


The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.

Takagaki Y, MacDonald CC, Shenk T, Manley JL.

Proc Natl Acad Sci U S A. 1992 Feb 15;89(4):1403-7.

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