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Items: 1 to 20 of 168

1.

Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.

Silander K, Mohlke KL, Scott LJ, Peck EC, Hollstein P, Skol AD, Jackson AU, Deloukas P, Hunt S, Stavrides G, Chines PS, Erdos MR, Narisu N, Conneely KN, Li C, Fingerlin TE, Dhanjal SK, Valle TT, Bergman RN, Tuomilehto J, Watanabe RM, Boehnke M, Collins FS.

Diabetes. 2004 Apr;53(4):1141-9.

3.

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

Ghosh S, Watanabe RM, Hauser ER, Valle T, Magnuson VL, Erdos MR, Langefeld CD, Balow J Jr, Ally DS, Kohtamaki K, Chines P, Birznieks G, Kaleta HS, Musick A, Te C, Tannenbaum J, Eldridge W, Shapiro S, Martin C, Witt A, So A, Chang J, Shurtleff B, Porter R, Kudelko K, Unni A, Segal L, Sharaf R, Blaschak-Harvan J, Eriksson J, Tenkula T, Vidgren G, Ehnholm C, Tuomilehto-Wolf E, Hagopian W, Buchanan TA, Tuomilehto J, Bergman RN, Collins FS, Boehnke M.

Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2198-203.

4.

Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish.

Damcott CM, Hoppman N, Ott SH, Reinhart LJ, Wang J, Pollin TI, O'Connell JR, Mitchell BD, Shuldiner AR.

Diabetes. 2004 Dec;53(12):3337-41.

5.

No evidence for linkage at candidate type 2 diabetes susceptibility loci on chromosomes 12 and 20 in United Kingdom Caucasians.

Frayling TM, McCarthy MI, Walker M, Levy JC, O'Rahilly S, Hitman GA, Rao PV, Bennett AJ, Jones EC, Menzel S, Ellard S, Hattersley AT.

J Clin Endocrinol Metab. 2000 Feb;85(2):853-7.

PMID:
10690901
6.

Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people.

Winckler W, Graham RR, de Bakker PI, Sun M, Almgren P, Tuomi T, Gaudet D, Hudson TJ, Ardlie KG, Daly MJ, Hirschhorn JN, Groop L, Altshuler D.

Diabetes. 2005 Mar;54(3):886-92.

7.

Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population.

Vaxillaire M, Dina C, Lobbens S, Dechaume A, Vasseur-Delannoy V, Helbecque N, Charpentier G, Froguel P.

Diabetologia. 2005 Mar;48(3):440-4. Epub 2005 Feb 25.

PMID:
15735892
8.

Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.

Hansen SK, Rose CS, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T.

Diabetologia. 2005 Mar;48(3):452-8. Epub 2005 Feb 25.

PMID:
15735891
9.

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.

Weedon MN, Owen KR, Shields B, Hitman G, Walker M, McCarthy MI, Love-Gregory LD, Permutt MA, Hattersley AT, Frayling TM.

Diabetes. 2004 Nov;53(11):3002-6.

10.

Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p.

Mori Y, Otabe S, Dina C, Yasuda K, Populaire C, Lecoeur C, Vatin V, Durand E, Hara K, Okada T, Tobe K, Boutin P, Kadowaki T, Froguel P.

Diabetes. 2002 Apr;51(4):1247-55.

11.

Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q.

Malecki MT, Antonellis A, Casey P, Ji L, Wantman M, Warram JH, Krolewski AS.

Diabetes. 1998 Jun;47(6):970-2. No abstract available.

PMID:
9604877
12.

Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes.

Bagwell AM, Bento JL, Mychaleckyj JC, Freedman BI, Langefeld CD, Bowden DW.

Diabetes. 2005 Apr;54(4):1185-90.

13.

Analysis of the HNF4 alpha gene in Caucasian type II diabetic nephropathic patients.

Price JA, Fossey SC, Sale MM, Brewer CS, Freedman BI, Wuerth JP, Bowden DW.

Diabetologia. 2000 Mar;43(3):364-72.

PMID:
10768098
14.

The role of the HNF4alpha enhancer in type 2 diabetes.

Mitchell SM, Gloyn AL, Owen KR, Hattersley AT, Frayling TM.

Mol Genet Metab. 2002 Jun;76(2):148-51.

PMID:
12083813
15.

Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population.

Hara K, Horikoshi M, Kitazato H, Ito C, Noda M, Ohashi J, Froguel P, Tokunaga K, Tobe K, Nagai R, Kadowaki T.

Diabetes. 2006 May;55(5):1260-4.

16.

Variants in the hepatocyte nuclear factor-1alpha and -4alpha genes in Finnish and Chinese subjects with late-onset type 2 diabetes.

Rissanen J, Wang H, Miettinen R, Kärkkäinen P, Kekäläinen P, Mykkänen L, Kuusisto J, Karhapää P, Niskanen L, Uusitupa M, Laakso M.

Diabetes Care. 2000 Oct;23(10):1533-8.

17.

Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.

Muller YL, Infante AM, Hanson RL, Love-Gregory L, Knowler W, Bogardus C, Baier LJ.

Diabetes. 2005 Oct;54(10):3035-9.

18.

Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.

Johansson S, Raeder H, Eide SA, Midthjell K, Hveem K, Søvik O, Molven A, Njølstad PR.

Diabetes. 2007 Dec;56(12):3112-7. Epub 2007 Sep 7.

19.
20.

Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.

Barroso I, Luan J, Wheeler E, Whittaker P, Wasson J, Zeggini E, Weedon MN, Hunt S, Venkatesh R, Frayling TM, Delgado M, Neuman RJ, Zhao J, Sherva R, Glaser B, Walker M, Hitman G, McCarthy MI, Hattersley AT, Permutt MA, Wareham NJ, Deloukas P.

Diabetes. 2008 Nov;57(11):3161-5. doi: 10.2337/db08-0719. Epub 2008 Aug 26.

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