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The hepatitis C virus NS5A protein binds to members of the Src family of tyrosine kinases and regulates kinase activity.

Macdonald A, Crowder K, Street A, McCormick C, Harris M.

J Gen Virol. 2004 Mar;85(Pt 3):721-9.


Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

Macdonald A, Mazaleyrat S, McCormick C, Street A, Burgoyne NJ, Jackson RM, Cazeaux V, Shelton H, Saksela K, Harris M.

J Gen Virol. 2005 Apr;86(Pt 4):1035-44.


Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases.

Poghosyan Z, Robbins SM, Houslay MD, Webster A, Murphy G, Edwards DR.

J Biol Chem. 2002 Feb 15;277(7):4999-5007. Epub 2001 Dec 10.


The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling.

Macdonald A, Crowder K, Street A, McCormick C, Saksela K, Harris M.

J Biol Chem. 2003 May 16;278(20):17775-84. Epub 2003 Mar 5.


Structure of the c-Src-SH3 domain in complex with a proline-rich motif of NS5A protein from the hepatitis C virus.

Bacarizo J, Martínez-Rodríguez S, Cámara-Artigas A.

J Struct Biol. 2015 Jan;189(1):67-72. doi: 10.1016/j.jsb.2014.11.004. Epub 2014 Nov 25.


Affinity of Src family kinase SH3 domains for HIV Nef in vitro does not predict kinase activation by Nef in vivo.

Briggs SD, Lerner EC, Smithgall TE.

Biochemistry. 2000 Jan 25;39(3):489-95.


The SH3 binding motif of HCV [corrected] NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.

Nanda SK, Herion D, Liang TJ.

Gastroenterology. 2006 Mar;130(3):794-809. Erratum in: Gastroenterology. 2006 Aug;131(2):687.


The SH3 domain of Src tyrosyl protein kinase interacts with the N-terminal splice region of the PDE4A cAMP-specific phosphodiesterase RPDE-6 (RNPDE4A5).

O'Connell JC, McCallum JF, McPhee I, Wakefield J, Houslay ES, Wishart W, Bolger G, Frame M, Houslay MD.

Biochem J. 1996 Aug 15;318 ( Pt 1):255-61.


Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.

Xiong W, Yang J, Wang M, Wang H, Rao Z, Zhong C, Xin X, Mo L, Yu S, Shen C, Zheng C.

J Virol. 2015 Jul;89(14):7385-400. doi: 10.1128/JVI.00567-15. Epub 2015 May 13.


Identification and characterization of amphiphysin II as a novel cellular interaction partner of the hepatitis C virus NS5A protein.

Zech B, Kurtenbach A, Krieger N, Strand D, Blencke S, Morbitzer M, Salassidis K, Cotten M, Wissing J, Obert S, Bartenschlager R, Herget T, Daub H.

J Gen Virol. 2003 Mar;84(Pt 3):555-60.


Differences in binding of PI 3-kinase to the src-homology domains 2 and 3 of p56 lck and p59 fyn tyrosine kinases.

Susa M, Rohner D, Bichsel S.

Biochem Biophys Res Commun. 1996 Mar 27;220(3):729-34.


HCV NS5A protein containing potential ligands for both Src homology 2 and 3 domains enhances autophosphorylation of Src family kinase Fyn in B cells.

Nakashima K, Takeuchi K, Chihara K, Horiguchi T, Sun X, Deng L, Shoji I, Hotta H, Sada K.

PLoS One. 2012;7(10):e46634. doi: 10.1371/journal.pone.0046634. Epub 2012 Oct 16.


The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.

Martin-Garcia JM, Luque I, Ruiz-Sanz J, Camara-Artigas A.

Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):1030-40. doi: 10.1107/S0907444912019798. Epub 2012 Jul 17.


Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain.

Schreiner SJ, Schiavone AP, Smithgall TE.

J Biol Chem. 2002 Nov 22;277(47):45680-7. Epub 2002 Sep 19.


c-Src is required for complex formation between the hepatitis C virus-encoded proteins NS5A and NS5B: a prerequisite for replication.

Pfannkuche A, Büther K, Karthe J, Poenisch M, Bartenschlager R, Trilling M, Hengel H, Willbold D, Häussinger D, Bode JG.

Hepatology. 2011 Apr;53(4):1127-36. doi: 10.1002/hep.24214.


Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M.

J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15.


The Hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade.

Street A, Macdonald A, Crowder K, Harris M.

J Biol Chem. 2004 Mar 26;279(13):12232-41. Epub 2004 Jan 5.


Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT.

J Biol Chem. 2002 Aug 2;277(31):28238-46. Epub 2002 May 23.

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