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Items: 1 to 20 of 159

1.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR.

EMBO J. 2004 Feb 25;23(4):833-43. Epub 2004 Feb 19.

2.

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade.

Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Mäkelä TP, Alessi DR, Hardie DG.

J Biol. 2003;2(4):28. Epub 2003 Sep 24.

3.

The regulation and function of mammalian AMPK-related kinases.

Bright NJ, Thornton C, Carling D.

Acta Physiol (Oxf). 2009 May;196(1):15-26. doi: 10.1111/j.1748-1716.2009.01971.x. Epub 2009 Feb 19. Review.

PMID:
19245655
4.

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

Sakamoto K, Göransson O, Hardie DG, Alessi DR.

Am J Physiol Endocrinol Metab. 2004 Aug;287(2):E310-7. Epub 2004 Apr 6.

5.

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK.

Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR.

J Cell Sci. 2005 Dec 1;118(Pt 23):5661-73.

6.

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

Jaleel M, Villa F, Deak M, Toth R, Prescott AR, Van Aalten DM, Alessi DR.

Biochem J. 2006 Mar 15;394(Pt 3):545-55.

7.

Effects of 3-phosphoglycerate and other metabolites on the activation of AMP-activated protein kinase by LKB1-STRAD-MO25.

Ellingson WJ, Chesser DG, Winder WW.

Am J Physiol Endocrinol Metab. 2007 Feb;292(2):E400-7. Epub 2006 Sep 19.

8.

The regulation and function of the NUAK family.

Sun X, Gao L, Chien HY, Li WC, Zhao J.

J Mol Endocrinol. 2013 Sep 10;51(2):R15-22. doi: 10.1530/JME-13-0063. Print 2013 Oct. Review.

PMID:
23873311
9.

Analysis of the LKB1-STRAD-MO25 complex.

Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR.

J Cell Sci. 2004 Dec 15;117(Pt 26):6365-75. Epub 2004 Nov 23.

10.

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate.

Jaleel M, McBride A, Lizcano JM, Deak M, Toth R, Morrice NA, Alessi DR.

FEBS Lett. 2005 Feb 28;579(6):1417-23.

11.

Long-chain acyl-CoA esters inhibit phosphorylation of AMP-activated protein kinase at threonine-172 by LKB1/STRAD/MO25.

Taylor EB, Ellingson WJ, Lamb JD, Chesser DG, Winder WW.

Am J Physiol Endocrinol Metab. 2005 Jun;288(6):E1055-61. Epub 2005 Jan 11.

12.

C-terminal phosphorylation of LKB1 is not required for regulation of AMP-activated protein kinase, BRSK1, BRSK2, or cell cycle arrest.

Fogarty S, Hardie DG.

J Biol Chem. 2009 Jan 2;284(1):77-84. doi: 10.1074/jbc.M806152200. Epub 2008 Oct 14.

14.

Characterization of the AMP-activated protein kinase pathway in chickens.

Proszkowiec-Weglarz M, Richards MP, Ramachandran R, McMurtry JP.

Comp Biochem Physiol B Biochem Mol Biol. 2006 Jan;143(1):92-106. Epub 2005 Dec 15.

PMID:
16343965
15.

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.

Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3329-35. Epub 2004 Feb 25.

16.

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

Xie Z, Dong Y, Zhang M, Cui MZ, Cohen RA, Riek U, Neumann D, Schlattner U, Zou MH.

J Biol Chem. 2006 Mar 10;281(10):6366-75. Epub 2006 Jan 9.

17.

Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade.

Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M.

FEBS J. 2006 Jun;273(12):2730-48.

18.

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.

Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.

Biochem Biophys Res Commun. 2004 Nov 19;324(3):986-92.

PMID:
15485651
19.

Evidence against regulation of AMP-activated protein kinase and LKB1/STRAD/MO25 activity by creatine phosphate.

Taylor EB, Ellingson WJ, Lamb JD, Chesser DG, Compton CL, Winder WW.

Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E661-9. Epub 2005 Nov 8.

20.

AICAR induces phosphorylation of AMPK in an ATM-dependent, LKB1-independent manner.

Sun Y, Connors KE, Yang DQ.

Mol Cell Biochem. 2007 Dec;306(1-2):239-45. Epub 2007 Sep 5.

PMID:
17786544

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