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Items: 1 to 20 of 162


Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.

Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.

Science. 2004 Mar 26;303(5666):2011-5. Epub 2004 Feb 19.


SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress.

Kobayashi Y, Furukawa-Hibi Y, Chen C, Horio Y, Isobe K, Ikeda K, Motoyama N.

Int J Mol Med. 2005 Aug;16(2):237-43.


The interaction between FOXO and SIRT1: tipping the balance towards survival.

Giannakou ME, Partridge L.

Trends Cell Biol. 2004 Aug;14(8):408-12. Review.


FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).

van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM.

J Biol Chem. 2004 Jul 9;279(28):28873-9. Epub 2004 May 4.


Mammalian SIRT1 represses forkhead transcription factors.

Motta MC, Divecha N, Lemieux M, Kamel C, Chen D, Gu W, Bultsma Y, McBurney M, Guarente L.

Cell. 2004 Feb 20;116(4):551-63.


SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction.

Wang F, Nguyen M, Qin FX, Tong Q.

Aging Cell. 2007 Aug;6(4):505-14. Epub 2007 May 23.


Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation.

Yang Y, Hou H, Haller EM, Nicosia SV, Bai W.

EMBO J. 2005 Mar 9;24(5):1021-32. Epub 2005 Feb 3.


The evolutionarily conserved longevity determinants HCF-1 and SIR-2.1/SIRT1 collaborate to regulate DAF-16/FOXO.

Rizki G, Iwata TN, Li J, Riedel CG, Picard CL, Jan M, Murphy CT, Lee SS.

PLoS Genet. 2011 Sep;7(9):e1002235. doi: 10.1371/journal.pgen.1002235. Epub 2011 Sep 1.


Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).

Hisahara S, Chiba S, Matsumoto H, Horio Y.

J Pharmacol Sci. 2005 Jul;98(3):200-4. Epub 2005 Jul 9. Review.


Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation.

Wang F, Chan CH, Chen K, Guan X, Lin HK, Tong Q.

Oncogene. 2012 Mar 22;31(12):1546-57. doi: 10.1038/onc.2011.347. Epub 2011 Aug 15.


Sirt1 regulates aging and resistance to oxidative stress in the heart.

Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J.

Circ Res. 2007 May 25;100(10):1512-21. Epub 2007 Apr 19.


FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress.

Furukawa-Hibi Y, Yoshida-Araki K, Ohta T, Ikeda K, Motoyama N.

J Biol Chem. 2002 Jul 26;277(30):26729-32. Epub 2002 Jun 4.


Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor.

An BS, Tavera-Mendoza LE, Dimitrov V, Wang X, Calderon MR, Wang HJ, White JH.

Mol Cell Biol. 2010 Oct;30(20):4890-900. doi: 10.1128/MCB.00180-10. Epub 2010 Aug 23.


Human Sir2 and the 'silencing' of p53 activity.

Smith J.

Trends Cell Biol. 2002 Sep;12(9):404-6.


Evidence for AKT-independent regulation of FOXO1 and FOXO3 in haematopoietic stem and progenitor cells.

Liang R, Rimmelé P, Bigarella CL, Yalcin S, Ghaffari S.

Cell Cycle. 2016;15(6):861-7. doi: 10.1080/15384101.2015.1123355.


SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.

Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG.

J Biol Chem. 2005 Mar 18;280(11):10264-76. Epub 2005 Jan 4.


Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression.

Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M.

J Biol Chem. 2003 Oct 31;278(44):43041-50. Epub 2003 Aug 19.


Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation.

Li K, Casta A, Wang R, Lozada E, Fan W, Kane S, Ge Q, Gu W, Orren D, Luo J.

J Biol Chem. 2008 Mar 21;283(12):7590-8. doi: 10.1074/jbc.M709707200. Epub 2008 Jan 17.


Regulation of FoxO activity by CBP/p300-mediated acetylation.

van der Heide LP, Smidt MP.

Trends Biochem Sci. 2005 Feb;30(2):81-6.


An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity.

Stankovic-Valentin N, Deltour S, Seeler J, Pinte S, Vergoten G, Guérardel C, Dejean A, Leprince D.

Mol Cell Biol. 2007 Apr;27(7):2661-75. Epub 2007 Feb 5.

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