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DNA-PKcs function regulated specifically by protein phosphatase 5.

Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ, Wabl M.

Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1247-52. Epub 2004 Jan 20.


Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP.

Mol Cell Biol. 2010 Mar;30(6):1368-81. doi: 10.1128/MCB.00741-09. Epub 2010 Jan 11.


Protein phosphatases regulate DNA-dependent protein kinase activity.

Douglas P, Moorhead GB, Ye R, Lees-Miller SP.

J Biol Chem. 2001 Jun 1;276(22):18992-8. Epub 2001 Mar 16.


The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation.

Merkle D, Douglas P, Moorhead GB, Leonenko Z, Yu Y, Cramb D, Bazett-Jones DP, Lees-Miller SP.

Biochemistry. 2002 Oct 22;41(42):12706-14.


Role of DNA-PK subunits in radiosensitization by hyperthermia.

Woudstra EC, Konings AW, Jeggo PA, Kampinga HH.

Radiat Res. 1999 Aug;152(2):214-8.


Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis.

Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP.

Biosci Rep. 2014 Jun 25;34(3). pii: e00113. doi: 10.1042/BSR20140051.


Accurate in vitro end joining of a DNA double strand break with partially cohesive 3'-overhangs and 3'-phosphoglycolate termini: effect of Ku on repair fidelity.

Chen S, Inamdar KV, Pfeiffer P, Feldmann E, Hannah MF, Yu Y, Lee JW, Zhou T, Lees-Miller SP, Povirk LF.

J Biol Chem. 2001 Jun 29;276(26):24323-30. Epub 2001 Apr 17.


Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

Chen BP, Chan DW, Kobayashi J, Burma S, Asaithamby A, Morotomi-Yano K, Botvinick E, Qin J, Chen DJ.

J Biol Chem. 2005 Apr 15;280(15):14709-15. Epub 2005 Jan 26.


Novel localization of the DNA-PK complex in lipid rafts: a putative role in the signal transduction pathway of the ionizing radiation response.

Lucero H, Gae D, Taccioli GE.

J Biol Chem. 2003 Jun 13;278(24):22136-43. Epub 2003 Apr 2. Erratum in: J Biol Chem. 2003 Nov 7;278(45):45040.


Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant glioma cells by inducing autophagy.

Daido S, Yamamoto A, Fujiwara K, Sawaya R, Kondo S, Kondo Y.

Cancer Res. 2005 May 15;65(10):4368-75.


Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.

Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS.

Cancer Res. 2005 Mar 1;65(5):1670-7.


Regulation of DNA double-strand break repair pathway choice.

Shrivastav M, De Haro LP, Nickoloff JA.

Cell Res. 2008 Jan;18(1):134-47. Review.


DNA-dependent protein kinase does not play a role in adaptive survival responses to ionizing radiation.

Odegaard E, Yang CR, Boothman DA.

Environ Health Perspect. 1998 Feb;106 Suppl 1:301-5.


DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.

Allen C, Kurimasa A, Brenneman MA, Chen DJ, Nickoloff JA.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3758-63.


Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

Chen BP, Uematsu N, Kobayashi J, Lerenthal Y, Krempler A, Yajima H, Löbrich M, Shiloh Y, Chen DJ.

J Biol Chem. 2007 Mar 2;282(9):6582-7. Epub 2006 Dec 21.


UV sensitivity and impaired nucleotide excision repair in DNA-dependent protein kinase mutant cells.

Muller C, Calsou P, Frit P, Cayrol C, Carter T, Salles B.

Nucleic Acids Res. 1998 Mar 15;26(6):1382-9.


Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.

Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC.

Cell. 2000 Sep 15;102(6):721-9.


Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination.

Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, Sleckman BP.

Mol Cell Biol. 2013 Sep;33(18):3568-79. doi: 10.1128/MCB.00308-13. Epub 2013 Jul 8.


Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase.

Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP.

Biochem J. 2002 Nov 15;368(Pt 1):243-51.

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