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Items: 1 to 20 of 254


Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.

Fraering PC, LaVoie MJ, Ye W, Ostaszewski BL, Kimberly WT, Selkoe DJ, Wolfe MS.

Biochemistry. 2004 Jan 20;43(2):323-33.


Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein.

Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J.

J Neurochem. 2004 Apr;89(1):44-53.


gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.

Strömberg K, Hansson EM, Laudon H, Bergstedt S, Näslund J, Lundkvist J, Lendahl U.

J Neurochem. 2005 Nov;95(3):880-90. Epub 2005 Aug 31.


The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity.

Bergman A, Laudon H, Winblad B, Lundkvist J, Näslund J.

J Biol Chem. 2004 Oct 29;279(44):45564-72. Epub 2004 Aug 20.


Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex.

Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H.

J Biol Chem. 2004 May 28;279(22):23255-61. Epub 2004 Mar 23.


PEN-2 enhances gamma-cleavage after presenilin heterodimer formation.

Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H.

J Neurochem. 2004 Sep;90(6):1402-13.


Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.


Purification and characterization of the human gamma-secretase complex.

Fraering PC, Ye W, Strub JM, Dolios G, LaVoie MJ, Ostaszewski BL, van Dorsselaer A, Wang R, Selkoe DJ, Wolfe MS.

Biochemistry. 2004 Aug 3;43(30):9774-89.


Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.

Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H.

Genes Cells. 2006 Jan;11(1):83-93.


The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex.

Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW.

J Biol Chem. 2003 Oct 31;278(44):43284-91. Epub 2003 Aug 12.


Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1.

Watanabe N, Tomita T, Sato C, Kitamura T, Morohashi Y, Iwatsubo T.

J Biol Chem. 2005 Dec 23;280(51):41967-75. Epub 2005 Oct 18.


Identification of distinct gamma-secretase complexes with different APH-1 variants.

Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H.

J Biol Chem. 2004 Oct 1;279(40):41340-5. Epub 2004 Jul 30.


Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.

Hansson CA, Frykman S, Farmery MR, Tjernberg LO, Nilsberth C, Pursglove SE, Ito A, Winblad B, Cowburn RF, Thyberg J, Ankarcrona M.

J Biol Chem. 2004 Dec 3;279(49):51654-60. Epub 2004 Sep 28.


Gamma-secretase complex assembly within the early secretory pathway.

Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C.

J Biol Chem. 2005 Feb 25;280(8):6471-8. Epub 2004 Dec 10.


Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.

LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ.

J Biol Chem. 2003 Sep 26;278(39):37213-22. Epub 2003 Jul 11.

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