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Items: 1 to 20 of 79

1.

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.

Hingorani SR, Petricoin EF, Maitra A, Rajapakse V, King C, Jacobetz MA, Ross S, Conrads TP, Veenstra TD, Hitt BA, Kawaguchi Y, Johann D, Liotta LA, Crawford HC, Putt ME, Jacks T, Wright CV, Hruban RH, Lowy AM, Tuveson DA.

Cancer Cell. 2003 Dec;4(6):437-50.

2.

The Nestin progenitor lineage is the compartment of origin for pancreatic intraepithelial neoplasia.

Carrière C, Seeley ES, Goetze T, Longnecker DS, Korc M.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4437-42. Epub 2007 Mar 5.

3.

Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor.

Funahashi H, Satake M, Dawson D, Huynh NA, Reber HA, Hines OJ, Eibl G.

Cancer Res. 2007 Aug 1;67(15):7068-71. Epub 2007 Jul 24.

4.

Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.

Grippo PJ, Fitchev PS, Bentrem DJ, Melstrom LG, Dangi-Garimella S, Krantz SB, Heiferman MJ, Chung C, Adrian K, Cornwell ML, Flesche JB, Rao SM, Talamonti MS, Munshi HG, Crawford SE.

Gut. 2012 Oct;61(10):1454-64. doi: 10.1136/gutjnl-2011-300821. Epub 2012 Jan 10.

PMID:
22234980
5.

Concomitant pancreatic activation of Kras(G12D) and Tgfa results in cystic papillary neoplasms reminiscent of human IPMN.

Siveke JT, Einwächter H, Sipos B, Lubeseder-Martellato C, Klöppel G, Schmid RM.

Cancer Cell. 2007 Sep;12(3):266-79.

6.

Constitutively active Akt1 cooperates with KRas(G12D) to accelerate in vivo pancreatic tumor onset and progression.

Albury TM, Pandey V, Gitto SB, Dominguez L, Spinel LP, Talarchek J, Klein-Szanto AJ, Testa JR, Altomare DA.

Neoplasia. 2015 Feb;17(2):175-82. doi: 10.1016/j.neo.2014.12.006.

7.

Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma.

Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA.

Genes Dev. 2003 Dec 15;17(24):3112-26. Epub 2003 Dec 17.

8.

Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.

Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF.

Cancer Res. 2006 Jan 1;66(1):242-7.

9.

Acinar cells contribute to the molecular heterogeneity of pancreatic intraepithelial neoplasia.

Zhu L, Shi G, Schmidt CM, Hruban RH, Konieczny SF.

Am J Pathol. 2007 Jul;171(1):263-73.

11.

The biological features of PanIN initiated from oncogenic Kras mutation in genetically engineered mouse models.

Shen R, Wang Q, Cheng S, Liu T, Jiang H, Zhu J, Wu Y, Wang L.

Cancer Lett. 2013 Oct 1;339(1):135-43. doi: 10.1016/j.canlet.2013.07.010. Epub 2013 Jul 22.

12.

Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasia.

Kojima K, Vickers SM, Adsay NV, Jhala NC, Kim HG, Schoeb TR, Grizzle WE, Klug CA.

Cancer Res. 2007 Sep 1;67(17):8121-30.

13.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
14.

The conditional expression of KRAS G12D in mouse pancreas induces disorganization of endocrine islets prior the onset of ductal pre-cancerous lesions.

Gout J, Pommier RM, Vincent DF, Ripoche D, Goddard-Léon S, Colombe A, Treilleux I, Valcourt U, Tomasini R, Dufresne M, Bertolino P, Bartholin L.

Pancreatology. 2013 May-Jun;13(3):191-5. doi: 10.1016/j.pan.2013.02.001. Epub 2013 Feb 18.

PMID:
23719586
15.

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues.

Aichler M, Seiler C, Tost M, Siveke J, Mazur PK, Da Silva-Buttkus P, Bartsch DK, Langer P, Chiblak S, Dürr A, Höfler H, Klöppel G, Müller-Decker K, Brielmeier M, Esposito I.

J Pathol. 2012 Apr;226(5):723-34. doi: 10.1002/path.3017. Epub 2012 Jan 17.

PMID:
21984419
16.

Spatiotemporal proteomic analyses during pancreas cancer progression identifies serine/threonine stress kinase 4 (STK4) as a novel candidate biomarker for early stage disease.

Mirus JE, Zhang Y, Hollingsworth MA, Solan JL, Lampe PD, Hingorani SR.

Mol Cell Proteomics. 2014 Dec;13(12):3484-96. doi: 10.1074/mcp.M113.036517. Epub 2014 Sep 15.

17.

Molecular genetics of pancreatic intraepithelial neoplasia.

Feldmann G, Beaty R, Hruban RH, Maitra A.

J Hepatobiliary Pancreat Surg. 2007;14(3):224-32. Epub 2007 May 29. Review.

18.

MT1-MMP cooperates with Kras(G12D) to promote pancreatic fibrosis through increased TGF-β signaling.

Krantz SB, Shields MA, Dangi-Garimella S, Cheon EC, Barron MR, Hwang RF, Rao MS, Grippo PJ, Bentrem DJ, Munshi HG.

Mol Cancer Res. 2011 Oct;9(10):1294-304. doi: 10.1158/1541-7786.MCR-11-0023. Epub 2011 Aug 19.

19.

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.

PMID:
21684285
20.

N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer.

Su Y, Li J, Witkiewicz AK, Brennan D, Neill T, Talarico J, Radice GL.

Oncogene. 2012 Oct 11;31(41):4484-9. doi: 10.1038/onc.2011.574. Epub 2011 Dec 12.

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