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Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair.

Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F.

Mol Cell Biol. 2004 Jan;24(2):708-18.


Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining.

Zhuang J, Zhang J, Willers H, Wang H, Chung JH, van Gent DC, Hallahan DE, Powell SN, Xia F.

Cancer Res. 2006 Feb 1;66(3):1401-8.


Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways.

Keimling M, Volcic M, Csernok A, Wieland B, Dörk T, Wiesmüller L.

FASEB J. 2011 Nov;25(11):3849-60. doi: 10.1096/fj.11-185546. Epub 2011 Jul 21.


Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks.

Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y.

J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.


The role of the BRCA1 tumor suppressor in DNA double-strand break repair.

Zhang J, Powell SN.

Mol Cancer Res. 2005 Oct;3(10):531-9. Review.


Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.

Cortez D, Wang Y, Qin J, Elledge SJ.

Science. 1999 Nov 5;286(5442):1162-6.


Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.

Au WW, Henderson BR.

Cell Signal. 2007 Sep;19(9):1879-92. Epub 2007 May 1.


Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

Cerosaletti K, Concannon P.

J Biol Chem. 2004 Sep 10;279(37):38813-9. Epub 2004 Jul 1.


Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK.

Cancer Res. 2000 Jun 15;60(12):3299-304.


A subset of ATM- and ATR-dependent phosphorylation events requires the BRCA1 protein.

Foray N, Marot D, Gabriel A, Randrianarison V, Carr AM, Perricaudet M, Ashworth A, Jeggo P.

EMBO J. 2003 Jun 2;22(11):2860-71.


Regulation of DNA double-strand break repair pathway choice.

Shrivastav M, De Haro LP, Nickoloff JA.

Cell Res. 2008 Jan;18(1):134-47. Review.


Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

Chen L, Nievera CJ, Lee AY, Wu X.

J Biol Chem. 2008 Mar 21;283(12):7713-20. doi: 10.1074/jbc.M710245200. Epub 2008 Jan 2.


Breast cancer risk is associated with the genes encoding the DNA double-strand break repair Mre11/Rad50/Nbs1 complex.

Hsu HM, Wang HC, Chen ST, Hsu GC, Shen CY, Yu JC.

Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2024-32.


E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.

Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG.

Mol Cancer Res. 2004 Apr;2(4):203-14.


Brca1 controls homology-directed DNA repair.

Moynahan ME, Chiu JW, Koller BH, Jasin M.

Mol Cell. 1999 Oct;4(4):511-8.


Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response.

Li S, Ting NS, Zheng L, Chen PL, Ziv Y, Shiloh Y, Lee EY, Lee WH.

Nature. 2000 Jul 13;406(6792):210-5.


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