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Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.

Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):284-9. Epub 2003 Dec 19.


Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E.

Reiman EM, Caselli RJ, Yun LS, Chen K, Bandy D, Minoshima S, Thibodeau SN, Osborne D.

N Engl J Med. 1996 Mar 21;334(12):752-8.


18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons.

Knopman DS, Jack CR Jr, Wiste HJ, Lundt ES, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC.

Neurobiol Aging. 2014 Sep;35(9):2096-106. doi: 10.1016/j.neurobiolaging.2014.03.006. Epub 2014 Mar 11.


Hypometabolism in Alzheimer-affected brain regions in cognitively healthy Latino individuals carrying the apolipoprotein E epsilon4 allele.

Langbaum JB, Chen K, Caselli RJ, Lee W, Reschke C, Bandy D, Alexander GE, Burns CM, Kaszniak AW, Reeder SA, Corneveaux JJ, Allen AN, Pruzin J, Huentelman MJ, Fleisher AS, Reiman EM.

Arch Neurol. 2010 Apr;67(4):462-8. doi: 10.1001/archneurol.2010.30.


Correlations between apolipoprotein E epsilon4 gene dose and brain-imaging measurements of regional hypometabolism.

Reiman EM, Chen K, Alexander GE, Caselli RJ, Bandy D, Osborne D, Saunders AM, Hardy J.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8299-302. Epub 2005 Jun 2.


Increased brain activation during working memory in cognitively intact adults with the APOE epsilon4 allele.

Wishart HA, Saykin AJ, Rabin LA, Santulli RB, Flashman LA, Guerin SJ, Mamourian AC, Belloni DR, Rhodes CH, McAllister TW.

Am J Psychiatry. 2006 Sep;163(9):1603-10.


Apolipoprotein E polymorphism influences the cerebral metabolic pattern in Alzheimer's disease.

Mielke R, Zerres K, Uhlhaas S, Kessler J, Heiss WD.

Neurosci Lett. 1998 Sep 18;254(1):49-52.


The effect of APOE epsilon4 allele on cerebral glucose metabolism in AD is a function of age at onset.

Hirono N, Hashimoto M, Yasuda M, Ishii K, Sakamoto S, Kazui H, Mori E.

Neurology. 2002 Mar 12;58(5):743-50.


Patterns of brain activation in people at risk for Alzheimer's disease.

Bookheimer SY, Strojwas MH, Cohen MS, Saunders AM, Pericak-Vance MA, Mazziotta JC, Small GW.

N Engl J Med. 2000 Aug 17;343(7):450-6.


Correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E ε4 gene dose in cognitively normal adults: a cross-validation study using voxel-based multi-modal partial least squares.

Chen K, Ayutyanont N, Langbaum JB, Fleisher AS, Reschke C, Lee W, Liu X, Alexander GE, Bandy D, Caselli RJ, Reiman EM.

Neuroimage. 2012 May 1;60(4):2316-22. doi: 10.1016/j.neuroimage.2012.02.005. Epub 2012 Feb 12.


Glucose metabolism and gray-matter concentration in apolipoprotein E ε4 positive normal subjects.

Samuraki M, Matsunari I, Chen WP, Shima K, Yanase D, Takeda N, Matsuda H, Yamada M.

Neurobiol Aging. 2012 Oct;33(10):2321-3. doi: 10.1016/j.neurobiolaging.2011.11.020. Epub 2011 Dec 20.


Higher serum total cholesterol levels in late middle age are associated with glucose hypometabolism in brain regions affected by Alzheimer's disease and normal aging.

Reiman EM, Chen K, Langbaum JB, Lee W, Reschke C, Bandy D, Alexander GE, Caselli RJ.

Neuroimage. 2010 Jan 1;49(1):169-76. doi: 10.1016/j.neuroimage.2009.07.025. Epub 2009 Jul 23.


Posterior cingulate glucose metabolism, hippocampal glucose metabolism, and hippocampal volume in cognitively normal, late-middle-aged persons at 3 levels of genetic risk for Alzheimer disease.

Protas HD, Chen K, Langbaum JB, Fleisher AS, Alexander GE, Lee W, Bandy D, de Leon MJ, Mosconi L, Buckley S, Truran-Sacrey D, Schuff N, Weiner MW, Caselli RJ, Reiman EM.

JAMA Neurol. 2013 Mar 1;70(3):320-5.


Reduced posterior cingulate mitochondrial activity in expired young adult carriers of the APOE ε4 allele, the major late-onset Alzheimer's susceptibility gene.

Valla J, Yaari R, Wolf AB, Kusne Y, Beach TG, Roher AE, Corneveaux JJ, Huentelman MJ, Caselli RJ, Reiman EM.

J Alzheimers Dis. 2010;22(1):307-13. doi: 10.3233/JAD-2010-100129.


Cerebral glucose metabolism in patients with AD and different APOE genotypes.

Drzezga A, Riemenschneider M, Strassner B, Grimmer T, Peller M, Knoll A, Wagenpfeil S, Minoshima S, Schwaiger M, Kurz A.

Neurology. 2005 Jan 11;64(1):102-7.


Correlations between apolipoprotein E epsilon4 gene dose and whole brain atrophy rates.

Chen K, Reiman EM, Alexander GE, Caselli RJ, Gerkin R, Bandy D, Domb A, Osborne D, Fox N, Crum WR, Saunders AM, Hardy J.

Am J Psychiatry. 2007 Jun;164(6):916-21.


Brain metabolic decreases related to the dose of the ApoE e4 allele in Alzheimer's disease.

Mosconi L, Nacmias B, Sorbi S, De Cristofaro MT, Fayazz M, Tedde A, Bracco L, Herholz K, Pupi A.

J Neurol Neurosurg Psychiatry. 2004 Mar;75(3):370-6.


Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype.

Davidson Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Tian J, Shi J, Stopford C, Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N, Lendon CL, Neary D, Snowden JS, Mann DM.

J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):515-7.


APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease.

Pievani M, Galluzzi S, Thompson PM, Rasser PE, Bonetti M, Frisoni GB.

Neuroimage. 2011 Apr 1;55(3):909-19. doi: 10.1016/j.neuroimage.2010.12.081. Epub 2011 Jan 9.


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