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Items: 1 to 20 of 273

1.

Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

Gerber JG, Rhodes RJ, Gal J.

Chirality. 2004 Jan;16(1):36-44.

PMID:
14628297
2.

Stereo-selective metabolism of methadone by human liver microsomes and cDNA-expressed cytochrome P450s: a reconciliation.

Chang Y, Fang WB, Lin SN, Moody DE.

Basic Clin Pharmacol Toxicol. 2011 Jan;108(1):55-62. doi: 10.1111/j.1742-7843.2010.00628.x. Epub 2010 Sep 2.

3.

Enantiomeric metabolic interactions and stereoselective human methadone metabolism.

Totah RA, Allen KE, Sheffels P, Whittington D, Kharasch ED.

J Pharmacol Exp Ther. 2007 Apr;321(1):389-99. Epub 2007 Jan 26.

4.

Role of CYP2B6 in stereoselective human methadone metabolism.

Totah RA, Sheffels P, Roberts T, Whittington D, Thummel K, Kharasch ED.

Anesthesiology. 2008 Mar;108(3):363-74. doi: 10.1097/ALN.0b013e3181642938.

PMID:
18292673
5.

CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.

Ramírez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ.

Drug Metab Dispos. 2004 Sep;32(9):930-6.

6.

Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4.

Foster DJ, Somogyi AA, Bochner F.

Br J Clin Pharmacol. 1999 Apr;47(4):403-12.

7.

Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.

Heyn H, White RB, Stevens JC.

Drug Metab Dispos. 1996 Sep;24(9):948-54.

PMID:
8886603
9.

Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer.

Roy P, Tretyakov O, Wright J, Waxman DJ.

Drug Metab Dispos. 1999 Nov;27(11):1309-18.

10.

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment.

Crettol S, Déglon JJ, Besson J, Croquette-Krokkar M, Gothuey I, Hämmig R, Monnat M, Hüttemann H, Baumann P, Eap CB.

Clin Pharmacol Ther. 2005 Dec;78(6):593-604.

PMID:
16338275
11.

Methadone N-demethylation by the common CYP2B6 allelic variant CYP2B6.6.

Gadel S, Crafford A, Regina K, Kharasch ED.

Drug Metab Dispos. 2013 Apr;41(4):709-13. doi: 10.1124/dmd.112.050625. Epub 2013 Jan 8.

13.

Contribution of human cytochrome p-450 isoforms to the metabolism of the simplest phenothiazine neuroleptic promazine.

Wójcikowski J, Pichard-Garcia L, Maurel P, Daniel WA.

Br J Pharmacol. 2003 Apr;138(8):1465-74.

14.

Involvement of CYP2B6 in n-demethylation of ketamine in human liver microsomes.

Yanagihara Y, Kariya S, Ohtani M, Uchino K, Aoyama T, Yamamura Y, Iga T.

Drug Metab Dispos. 2001 Jun;29(6):887-90.

15.

Metabolism of N-methyl, N-propargylphenylethylamine: studies with human liver microsomes and cDNA expressed cytochrome P450 (CYP) enzymes.

Rittenbach KA, Holt A, Ling L, Shan J, Baker GB.

Cell Mol Neurobiol. 2007 Mar;27(2):179-90. Epub 2006 Dec 8.

PMID:
17160483
16.

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.

Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2000 Oct;30(10):955-69.

PMID:
11315104
17.

Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes.

Murayama N, Imai N, Nakane T, Shimizu M, Yamazaki H.

Biochem Pharmacol. 2007 Jun 15;73(12):2020-6. Epub 2007 Mar 19.

PMID:
17433262
18.

Development of a method to measure methadone enantiomers and its metabolites without enantiomer standard compounds for the plasma of methadone maintenance patients.

Wang SC, Ho IK, Wu SL, Liu SC, Kuo HW, Lin KM, Liu YL.

Biomed Chromatogr. 2010 Jul;24(7):782-8. doi: 10.1002/bmc.1363.

PMID:
19904716
19.

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone.

Kharasch ED, Hoffer C, Whittington D, Sheffels P.

Clin Pharmacol Ther. 2004 Sep;76(3):250-69.

PMID:
15371986
20.

Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.

Ono S, Hatanaka T, Miyazawa S, Tsutsui M, Aoyama T, Gonzalez FJ, Satoh T.

Xenobiotica. 1996 Nov;26(11):1155-66.

PMID:
8948091

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