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Items: 1 to 20 of 291

1.

A2E, a byproduct of the visual cycle.

Sparrow JR, Fishkin N, Zhou J, Cai B, Jang YP, Krane S, Itagaki Y, Nakanishi K.

Vision Res. 2003 Dec;43(28):2983-90. Review.

2.

Observation of A2E oxidation products in human retinal lipofuscin.

Avalle LB, Wang Z, Dillon JP, Gaillard ER.

Exp Eye Res. 2004 Apr;78(4):895-8.

PMID:
15037123
3.

Lipofuscin and macular degeneration.

Wolf G.

Nutr Rev. 2003 Oct;61(10):342-6. Review.

PMID:
14604266
4.

A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor.

Iriyama A, Fujiki R, Inoue Y, Takahashi H, Tamaki Y, Takezawa S, Takeyama K, Jang WD, Kato S, Yanagi Y.

J Biol Chem. 2008 May 2;283(18):11947-53. doi: 10.1074/jbc.M708989200. Epub 2008 Mar 6.

5.
6.

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

Sparrow JR, Nakanishi K, Parish CA.

Invest Ophthalmol Vis Sci. 2000 Jun;41(7):1981-9.

PMID:
10845625
7.

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin.

Ben-Shabat S, Parish CA, Vollmer HR, Itagaki Y, Fishkin N, Nakanishi K, Sparrow JR.

J Biol Chem. 2002 Mar 1;277(9):7183-90. Epub 2001 Dec 26.

8.

The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.

Vives-Bauza C, Anand M, Shiraz AK, Magrane J, Gao J, Vollmer-Snarr HR, Manfredi G, Finnemann SC.

J Biol Chem. 2008 Sep 5;283(36):24770-80. doi: 10.1074/jbc.M800706200. Epub 2008 Jul 10. Erratum in: J Biol Chem. 2013 Nov 8;288(45):32639. Shirazi, Arash K [corrected to Shiraz, Ashton K].

9.

A2E: a component of ocular lipofuscin.

Lamb LE, Simon JD.

Photochem Photobiol. 2004 Feb;79(2):127-36. Review.

PMID:
15068025
10.

Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases.

Radu RA, Han Y, Bui TV, Nusinowitz S, Bok D, Lichter J, Widder K, Travis GH, Mata NL.

Invest Ophthalmol Vis Sci. 2005 Dec;46(12):4393-401. Erratum in: Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3735.

PMID:
16303925
11.

Oxidation of A2E results in the formation of highly reactive aldehydes and ketones.

Wang Z, Keller LM, Dillon J, Gaillard ER.

Photochem Photobiol. 2006 Sep-Oct;82(5):1251-7.

PMID:
16813456
12.

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

Kim SR, Jang YP, Jockusch S, Fishkin NE, Turro NJ, Sparrow JR.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19273-8. Epub 2007 Nov 28.

13.

A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration.

Yoon KD, Yamamoto K, Ueda K, Zhou J, Sparrow JR.

PLoS One. 2012;7(7):e41309. doi: 10.1371/journal.pone.0041309. Epub 2012 Jul 19.

14.

Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy.

Conley SM, Cai X, Makkia R, Wu Y, Sparrow JR, Naash MI.

Biochim Biophys Acta. 2012 Jul;1822(7):1169-79. doi: 10.1016/j.bbadis.2011.10.007. Epub 2011 Oct 13.

15.

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

Sparrow JR, Parish CA, Hashimoto M, Nakanishi K.

Invest Ophthalmol Vis Sci. 1999 Nov;40(12):2988-95.

PMID:
10549662
16.

A mechanistic study of the photooxidation of A2E, a component of human retinal lipofuscin.

Gaillard ER, Avalle LB, Keller LM, Wang Z, Reszka KJ, Dillon JP.

Exp Eye Res. 2004 Sep;79(3):313-9.

PMID:
15336493
17.

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

Sparrow JR, Zhou J, Ben-Shabat S, Vollmer H, Itagaki Y, Nakanishi K.

Invest Ophthalmol Vis Sci. 2002 Apr;43(4):1222-7.

PMID:
11923269
18.

Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration.

Radu RA, Mata NL, Nusinowitz S, Liu X, Sieving PA, Travis GH.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4742-7. Epub 2003 Apr 1.

19.

Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells.

Abeywickrama C, Matsuda H, Jockusch S, Zhou J, Jang YP, Chen BX, Itagaki Y, Erlanger BF, Nakanishi K, Turro NJ, Sparrow JR.

Proc Natl Acad Sci U S A. 2007 Sep 11;104(37):14610-5. Epub 2007 Sep 5.

20.

Blue light-absorbing intraocular lens and retinal pigment epithelium protection in vitro.

Sparrow JR, Miller AS, Zhou J.

J Cataract Refract Surg. 2004 Apr;30(4):873-8.

PMID:
15093654

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