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P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells.

Oruetxebarria I, Venturini F, Kekarainen T, Houweling A, Zuijderduijn LM, Mohd-Sarip A, Vries RG, Hoeben RC, Verrijzer CP.

J Biol Chem. 2004 Jan 30;279(5):3807-16. Epub 2003 Nov 6.


Reexpression of hSNF5 in malignant rhabdoid tumor cell lines causes cell cycle arrest through a p21(CIP1/WAF1)-dependent mechanism.

Kuwahara Y, Charboneau A, Knudsen ES, Weissman BE.

Cancer Res. 2010 Mar 1;70(5):1854-65. doi: 10.1158/0008-5472.CAN-09-1922. Epub 2010 Feb 23.


SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus.

Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP.

Mol Cell Biol. 2008 May;28(10):3457-64. doi: 10.1128/MCB.02019-07. Epub 2008 Mar 10.


A key role of the hSNF5/INI1 tumour suppressor in the control of the G1-S transition of the cell cycle.

Versteege I, Medjkane S, Rouillard D, Delattre O.

Oncogene. 2002 Sep 19;21(42):6403-12.


SNF5 reexpression in malignant rhabdoid tumors regulates transcription of target genes by recruitment of SWI/SNF complexes and RNAPII to the transcription start site of their promoters.

Kuwahara Y, Wei D, Durand J, Weissman BE.

Mol Cancer Res. 2013 Mar;11(3):251-60. doi: 10.1158/1541-7786.MCR-12-0390. Epub 2013 Jan 30.


Re-expression of hSNF5/INI1/BAF47 in pediatric tumor cells leads to G1 arrest associated with induction of p16ink4a and activation of RB.

Betz BL, Strobeck MW, Reisman DN, Knudsen ES, Weissman BE.

Oncogene. 2002 Aug 8;21(34):5193-203.


p16INK4A and p14ARF tumor suppressor pathways are deregulated in malignant rhabdoid tumors.

Venneti S, Le P, Martinez D, Eaton KW, Shyam N, Jordan-Sciutto KL, Pawel B, Biegel JA, Judkins AR.

J Neuropathol Exp Neurol. 2011 Jul;70(7):596-609. doi: 10.1097/NEN.0b013e31822146ca.


Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in a p53-dependent manner.

Kato H, Honma R, Sanda T, Fujiwara T, Ito E, Yanagisawa Y, Imai J, Okamoto T, Watanabe S.

Biochem Biophys Res Commun. 2007 Sep 28;361(3):580-5. Epub 2007 Jul 25.


Cell cycle arrest and repression of cyclin D1 transcription by INI1/hSNF5.

Zhang ZK, Davies KP, Allen J, Zhu L, Pestell RG, Zagzag D, Kalpana GV.

Mol Cell Biol. 2002 Aug;22(16):5975-88.


Aurora A is a repressed effector target of the chromatin remodeling protein INI1/hSNF5 required for rhabdoid tumor cell survival.

Lee S, Cimica V, Ramachandra N, Zagzag D, Kalpana GV.

Cancer Res. 2011 May 1;71(9):3225-35. doi: 10.1158/0008-5472.CAN-10-2167. Epub 2011 Apr 26.


SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription.

Lee D, Kim JW, Seo T, Hwang SG, Choi EJ, Choe J.

J Biol Chem. 2002 Jun 21;277(25):22330-7. Epub 2002 Apr 11.


The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements.

D'Amico M, Wu K, Fu M, Rao M, Albanese C, Russell RG, Lian H, Bregman D, White MA, Pestell RG.

Cancer Res. 2004 Jun 15;64(12):4122-30.


E2FBP1 antagonizes the p16(INK4A)-Rb tumor suppressor machinery for growth suppression and cellular senescence by regulating promyelocytic leukemia protein stability.

Fukuyo Y, Takahashi A, Hara E, Horikoshi N, Pandita TK, Nakajima T.

Int J Oral Sci. 2011 Oct;3(4):200-8. doi: 10.4248/IJOS11071.


Profiles of the 2 INK4a gene products, p16 and p14ARF, in human reference urothelium and bladder carcinomas, according to pRb and p53 protein status.

Le Frère-Belda MA, Gil Diez de Medina S, Daher A, Martin N, Albaud B, Heudes D, Abbou CC, Thiery JP, Zafrani ES, Radvanyi F, Chopin D.

Hum Pathol. 2004 Jul;35(7):817-24.


Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint.

Vries RG, Bezrookove V, Zuijderduijn LM, Kia SK, Houweling A, Oruetxebarria I, Raap AK, Verrijzer CP.

Genes Dev. 2005 Mar 15;19(6):665-70.


Cellular senescence regulated by SWI/SNF complex subunits through p53/p21 and p16/pRB pathway.

He L, Chen Y, Feng J, Sun W, Li S, Ou M, Tang L.

Int J Biochem Cell Biol. 2017 Sep;90:29-37. doi: 10.1016/j.biocel.2017.07.007. Epub 2017 Jul 15.


Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces apoptosis and cellular senescence in adult T-cell leukemia cells.

Hasegawa H, Yamada Y, Iha H, Tsukasaki K, Nagai K, Atogami S, Sugahara K, Tsuruda K, Ishizaki A, Kamihira S.

Leukemia. 2009 Nov;23(11):2090-101. doi: 10.1038/leu.2009.171. Epub 2009 Aug 27.


Targeting cyclin D1, a downstream effector of INI1/hSNF5, in rhabdoid tumors.

Alarcon-Vargas D, Zhang Z, Agarwal B, Challagulla K, Mani S, Kalpana GV.

Oncogene. 2006 Feb 2;25(5):722-34.


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