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Items: 1 to 20 of 116


Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.

Molofsky AV, Pardal R, Iwashita T, Park IK, Clarke MF, Morrison SJ.

Nature. 2003 Oct 30;425(6961):962-7. Epub 2003 Oct 22.


Bmi-1 over-expression in neural stem/progenitor cells increases proliferation and neurogenesis in culture but has little effect on these functions in vivo.

He S, Iwashita T, Buchstaller J, Molofsky AV, Thomas D, Morrison SJ.

Dev Biol. 2009 Apr 15;328(2):257-72. doi: 10.1016/j.ydbio.2009.01.020. Epub 2009 Jan 27.


Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF.

Nature. 2003 May 15;423(6937):302-5. Epub 2003 Apr 20.


Conditional activation of Bmi1 expression regulates self-renewal, apoptosis, and differentiation of neural stem/progenitor cells in vitro and in vivo.

Yadirgi G, Leinster V, Acquati S, Bhagat H, Shakhova O, Marino S.

Stem Cells. 2011 Apr;29(4):700-12. doi: 10.1002/stem.614.


Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain.

Fasano CA, Phoenix TN, Kokovay E, Lowry N, Elkabetz Y, Dimos JT, Lemischka IR, Studer L, Temple S.

Genes Dev. 2009 Mar 1;23(5):561-74. doi: 10.1101/gad.1743709.


shRNA knockdown of Bmi-1 reveals a critical role for p21-Rb pathway in NSC self-renewal during development.

Fasano CA, Dimos JT, Ivanova NB, Lowry N, Lemischka IR, Temple S.

Cell Stem Cell. 2007 Jun 7;1(1):87-99. doi: 10.1016/j.stem.2007.04.001.


The polycomb group gene product Ezh2 regulates proliferation and differentiation of murine hepatic stem/progenitor cells.

Aoki R, Chiba T, Miyagi S, Negishi M, Konuma T, Taniguchi H, Ogawa M, Yokosuka O, Iwama A.

J Hepatol. 2010 Jun;52(6):854-63. doi: 10.1016/j.jhep.2010.01.027. Epub 2010 Mar 24.


Bmi-1 regulates the differentiation and clonogenic self-renewal of I-type neuroblastoma cells in a concentration-dependent manner.

Cui H, Ma J, Ding J, Li T, Alam G, Ding HF.

J Biol Chem. 2006 Nov 10;281(45):34696-704. Epub 2006 Sep 18.


Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M.

Genes Dev. 2005 Jun 15;19(12):1438-43.


Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M.

Cancer Cell. 2007 Oct;12(4):328-41.


Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation.

Lukacs RU, Memarzadeh S, Wu H, Witte ON.

Cell Stem Cell. 2010 Dec 3;7(6):682-93. doi: 10.1016/j.stem.2010.11.013.


Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.

Iwama A, Oguro H, Negishi M, Kato Y, Morita Y, Tsukui H, Ema H, Kamijo T, Katoh-Fukui Y, Koseki H, van Lohuizen M, Nakauchi H.

Immunity. 2004 Dec;21(6):843-51.


Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression.

Nishino J, Kim I, Chada K, Morrison SJ.

Cell. 2008 Oct 17;135(2):227-39. doi: 10.1016/j.cell.2008.09.017.


Bmi1 loss produces an increase in astroglial cells and a decrease in neural stem cell population and proliferation.

Zencak D, Lingbeek M, Kostic C, Tekaya M, Tanger E, Hornfeld D, Jaquet M, Munier FL, Schorderet DF, van Lohuizen M, Arsenijevic Y.

J Neurosci. 2005 Jun 15;25(24):5774-83.


Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

Pardal R, Molofsky AV, He S, Morrison SJ.

Cold Spring Harb Symp Quant Biol. 2005;70:177-85. Review.


Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality.

Ke Y, Zhang EE, Hagihara K, Wu D, Pang Y, Klein R, Curran T, Ranscht B, Feng GS.

Mol Cell Biol. 2007 Oct;27(19):6706-17. Epub 2007 Jul 23.


Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.

Bruggeman SW, Hulsman D, van Lohuizen M.

Biochim Biophys Acta. 2009 May;1790(5):351-60. doi: 10.1016/j.bbagen.2009.03.009. Epub 2009 Mar 16.


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