Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 149


Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding.

Chen MS, Ryan CE, Piwnica-Worms H.

Mol Cell Biol. 2003 Nov;23(21):7488-97.


Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ.

Science. 1997 Sep 5;277(5331):1497-501.


Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1.

Zeng Y, Forbes KC, Wu Z, Moreno S, Piwnica-Worms H, Enoch T.

Nature. 1998 Oct 1;395(6701):507-10.


Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism.

Uto K, Inoue D, Shimuta K, Nakajo N, Sagata N.

EMBO J. 2004 Aug 18;23(16):3386-96. Epub 2004 Jul 22.


SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase.

Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge SJ, Harper JW.

Genes Dev. 2003 Dec 15;17(24):3062-74. Epub 2003 Dec 17.


NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.

Melixetian M, Klein DK, Sørensen CS, Helin K.

Nat Cell Biol. 2009 Oct;11(10):1247-53. doi: 10.1038/ncb1969. Epub 2009 Sep 6.


Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

Mailand N, Podtelejnikov AV, Groth A, Mann M, Bartek J, Lukas J.

EMBO J. 2002 Nov 1;21(21):5911-20.


Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling.

Jurvansuu J, Fragkos M, Ingemarsdotter C, Beard P.

J Mol Biol. 2007 Sep 14;372(2):397-406. Epub 2007 Jul 3.


CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.

Schmitt E, Boutros R, Froment C, Monsarrat B, Ducommun B, Dozier C.

J Cell Sci. 2006 Oct 15;119(Pt 20):4269-75. Epub 2006 Sep 26.


14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damage.

Kasahara K, Goto H, Enomoto M, Tomono Y, Kiyono T, Inagaki M.

EMBO J. 2010 Aug 18;29(16):2802-12. doi: 10.1038/emboj.2010.157. Epub 2010 Jul 16.


Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.

Goloudina A, Yamaguchi H, Chervyakova DB, Appella E, Fornace AJ Jr, Bulavin DV.

Cell Cycle. 2003 Sep-Oct;2(5):473-8.


Rapid destruction of human Cdc25A in response to DNA damage.

Mailand N, Falck J, Lukas C, Syljuâsen RG, Welcker M, Bartek J, Lukas J.

Science. 2000 May 26;288(5470):1425-9.


ATR, Claspin and the Rad9-Rad1-Hus1 complex regulate Chk1 and Cdc25A in the absence of DNA damage.

Sørensen CS, Syljuåsen RG, Lukas J, Bartek J.

Cell Cycle. 2004 Jul;3(7):941-5. Epub 2004 Jul 13.


The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin.

Zhang Y, Qu D, Morris EJ, O'Hare MJ, Callaghan SM, Slack RS, Geller HM, Park DS.

J Neurosci. 2006 Aug 23;26(34):8819-28.


Cdc25B cooperates with Cdc25A to induce mitosis but has a unique role in activating cyclin B1-Cdk1 at the centrosome.

Lindqvist A, Källström H, Lundgren A, Barsoum E, Rosenthal CK.

J Cell Biol. 2005 Oct 10;171(1):35-45.


FGF inhibits the activity of the cyclin B1/CDK1 kinase to induce a transient G₂arrest in RCS chondrocytes.

Tran T, Kolupaeva V, Basilico C.

Cell Cycle. 2010 Nov 1;9(21):4379-86. Epub 2010 Nov 15.


Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.

Timofeev O, Cizmecioglu O, Settele F, Kempf T, Hoffmann I.

J Biol Chem. 2010 May 28;285(22):16978-90. doi: 10.1074/jbc.M109.096552. Epub 2010 Apr 1.


[Degradation of Cdc25A phosphatase in HeLa cells under normal and stress conditions].

Goloudina AR, Aksenov ND, Pospelov VA.

Tsitologiia. 2004;46(5):423-30. Russian.


Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216.

Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H.

Science. 1997 Sep 5;277(5331):1501-5.


Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J.

Cancer Cell. 2003 Mar;3(3):247-58.

Supplemental Content

Support Center