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Items: 1 to 20 of 109

1.

Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase.

Blanco J, Moore RA, Viola RE.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12613-7. Epub 2003 Oct 14.

2.

The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.

Blanco J, Moore RA, Faehnle CR, Coe DM, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2004 Aug;60(Pt 8):1388-95. Epub 2004 Jul 21.

PMID:
15272161
3.

Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.

Blanco J, Moore RA, Faehnle CR, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2004 Oct;60(Pt 10):1808-15. Epub 2004 Sep 23.

PMID:
15388927
4.

Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase.

Faehnle CR, Blanco J, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2320-4. Epub 2004 Nov 26.

PMID:
15583380
5.

Molecular modelling and comparative structural account of aspartyl beta-semialdehyde dehydrogenase of Mycobacterium tuberculosis (H37Rv).

Singh A, Kushwaha HR, Sharma P.

J Mol Model. 2008 Apr;14(4):249-63. doi: 10.1007/s00894-008-0267-2. Epub 2008 Jan 31.

PMID:
18236087
6.

A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae.

Blanco J, Moore RA, Kabaleeswaran V, Viola RE.

Protein Sci. 2003 Jan;12(1):27-33.

7.

Active site analysis of the potential antimicrobial target aspartate semialdehyde dehydrogenase.

Hadfield A, Shammas C, Kryger G, Ringe D, Petsko GA, Ouyang J, Viola RE.

Biochemistry. 2001 Dec 4;40(48):14475-83.

PMID:
11724560
8.

Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog.

Arachea BT, Liu X, Pavlovsky AG, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):205-12. doi: 10.1107/S0907444909052834. Epub 2010 Jan 22.

PMID:
20124701
9.

Structures of ternary complexes of aspartate-semialdehyde dehydrogenase (Rv3708c) from Mycobacterium tuberculosis H37Rv.

Vyas R, Tewari R, Weiss MS, Karthikeyan S.

Acta Crystallogr D Biol Crystallogr. 2012 Jun;68(Pt 6):671-9. doi: 10.1107/S0907444912007330. Epub 2012 May 17.

PMID:
22683789
10.
11.

Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis.

Hadfield A, Kryger G, Ouyang J, Petsko GA, Ringe D, Viola R.

J Mol Biol. 1999 Jun 18;289(4):991-1002.

PMID:
10369777
12.

The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae.

Viola RE, Liu X, Ohren JF, Faehnle CR.

Acta Crystallogr D Biol Crystallogr. 2008 Mar;64(Pt 3):321-30. doi: 10.1107/S0907444907068552. Epub 2008 Feb 20.

PMID:
18323627
13.

Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase from Mycobacterium tuberculosis in complex with NADP(+).

Cherney LT, Cherney MM, Garen CR, Niu C, Moradian F, James MN.

J Mol Biol. 2007 Apr 13;367(5):1357-69. Epub 2007 Jan 20.

PMID:
17316682
14.

Structural and biochemical investigations of the catalytic mechanism of an NADP-dependent aldehyde dehydrogenase from Streptococcus mutans.

Cobessi D, TĂȘte-Favier F, Marchal S, Branlant G, Aubry A.

J Mol Biol. 2000 Jun 30;300(1):141-52.

PMID:
10864505
15.

A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii.

Faehnle CR, Ohren JF, Viola RE.

J Mol Biol. 2005 Nov 11;353(5):1055-68. Epub 2005 Sep 29.

PMID:
16225889
16.

A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway.

Pavlovsky AG, Thangavelu B, Bhansali P, Viola RE.

Acta Crystallogr D Biol Crystallogr. 2014 Dec 1;70(Pt 12):3244-52. doi: 10.1107/S1399004714023979. Epub 2014 Nov 22.

PMID:
25478842
17.

Structure of a fungal form of aspartate semialdehyde dehydrogenase from Cryptococcus neoformans.

Dahal G, Viola RE.

Acta Crystallogr F Struct Biol Commun. 2015 Nov;71(Pt 11):1365-71. doi: 10.1107/S2053230X15017495. Epub 2015 Oct 23.

18.

Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms.

Moore RA, Bocik WE, Viola RE.

Protein Expr Purif. 2002 Jun;25(1):189-94.

PMID:
12071715
19.

Shape-based virtual screening, docking, and molecular dynamics simulations to identify Mtb-ASADH inhibitors.

Kumar R, Garg P, Bharatam PV.

J Biomol Struct Dyn. 2015;33(5):1082-93. doi: 10.1080/07391102.2014.929535. Epub 2014 Jun 23.

PMID:
24875451
20.

High-resolution structures reveal details of domain closure and "half-of-sites-reactivity" in Escherichia coli aspartate beta-semialdehyde dehydrogenase.

Nichols CE, Dhaliwal B, Lockyer M, Hawkins AR, Stammers DK.

J Mol Biol. 2004 Aug 13;341(3):797-806.

PMID:
15288787

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