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Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.

Botelho RJ, Efe JA, Teis D, Emr SD.

Mol Biol Cell. 2008 Oct;19(10):4273-86. doi: 10.1091/mbc.E08-04-0405. Epub 2008 Jul 23.


Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

Gary JD, Sato TK, Stefan CJ, Bonangelino CJ, Weisman LS, Emr SD.

Mol Biol Cell. 2002 Apr;13(4):1238-51.


Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body.

Dove SK, McEwen RK, Mayes A, Hughes DC, Beggs JD, Michell RH.

Curr Biol. 2002 Jun 4;12(11):885-93.


Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.

Alghamdi TA, Ho CY, Mrakovic A, Taylor D, Mao D, Botelho RJ.

J Biol Chem. 2013 Mar 29;288(13):9363-72. doi: 10.1074/jbc.M113.453712. Epub 2013 Feb 6.


Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects.

Wiradjaja F, Ooms LM, Tahirovic S, Kuhne E, Devenish RJ, Munn AL, Piper RC, Mayinger P, Mitchell CA.

J Biol Chem. 2007 Jun 1;282(22):16295-307. Epub 2007 Mar 28.


Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis.

Gary JD, Wurmser AE, Bonangelino CJ, Weisman LS, Emr SD.

J Cell Biol. 1998 Oct 5;143(1):65-79.


The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole.

Ho CY, Choy CH, Wattson CA, Johnson DE, Botelho RJ.

J Biol Chem. 2015 Apr 10;290(15):9919-28. doi: 10.1074/jbc.M114.613984. Epub 2015 Feb 20.


A protein complex that regulates PtdIns(3,5)P2 levels.

Michell RH, Dove SK.

EMBO J. 2009 Jan 21;28(2):86-7. doi: 10.1038/emboj.2008.270.


Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.

Dove SK, Piper RC, McEwen RK, Yu JW, King MC, Hughes DC, Thuring J, Holmes AB, Cooke FT, Michell RH, Parker PJ, Lemmon MA.

EMBO J. 2004 May 5;23(9):1922-33. Epub 2004 Apr 22.


VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS.

EMBO J. 2008 Dec 17;27(24):3221-34. doi: 10.1038/emboj.2008.248. Epub 2008 Nov 27.


Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J.

Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH.

Nature. 2007 Jul 5;448(7149):68-72. Epub 2007 Jun 17.


Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation.

Rudge SA, Sciorra VA, Iwamoto M, Zhou C, Strahl T, Morris AJ, Thorner J, Engebrecht J.

Mol Biol Cell. 2004 Jan;15(1):207-18. Epub 2003 Oct 3.


Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology.

Bonangelino CJ, Catlett NL, Weisman LS.

Mol Cell Biol. 1997 Dec;17(12):6847-58.


Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.

Tahirovic S, Schorr M, Mayinger P.

Traffic. 2005 Feb;6(2):116-30.


Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

Bonangelino CJ, Nau JJ, Duex JE, Brinkman M, Wurmser AE, Gary JD, Emr SD, Weisman LS.

J Cell Biol. 2002 Mar 18;156(6):1015-28. Epub 2002 Mar 11.

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