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HS5 of the human beta-globin locus control region: a developmental stage-specific border in erythroid cells.

Wai AW, Gillemans N, Raguz-Bolognesi S, Pruzina S, Zafarana G, Meijer D, Philipsen S, Grosveld F.

EMBO J. 2003 Sep 1;22(17):4489-500.


Human beta-globin locus control region HS5 contains CTCF- and developmental stage-dependent enhancer-blocking activity in erythroid cells.

Tanimoto K, Sugiura A, Omori A, Felsenfeld G, Engel JD, Fukamizu A.

Mol Cell Biol. 2003 Dec;23(24):8946-52.


The ERV-9 LTR enhancer is not blocked by the HS5 insulator and synthesizes through the HS5 site non-coding, long RNAs that regulate LTR enhancer function.

Ling J, Pi W, Yu X, Bengra C, Long Q, Jin H, Seyfang A, Tuan D.

Nucleic Acids Res. 2003 Aug 1;31(15):4582-96.


Structural analysis and mapping of DNase I hypersensitivity of HS5 of the beta-globin locus control region.

Li Q, Zhang M, Duan Z, Stamatoyannopoulos G.

Genomics. 1999 Oct 15;61(2):183-93.


Developmental specificity of the interaction between the locus control region and embryonic or fetal globin genes in transgenic mice with an HS3 core deletion.

Navas PA, Peterson KR, Li Q, Skarpidi E, Rohde A, Shaw SE, Clegg CH, Asano H, Stamatoyannopoulos G.

Mol Cell Biol. 1998 Jul;18(7):4188-96.


Mutation of a transcriptional motif of a distant regulatory element reduces the expression of embryonic and fetal globin genes.

Navas PA, Swank RA, Yu M, Peterson KR, Stamatoyannopoulos G.

Hum Mol Genet. 2003 Nov 15;12(22):2941-8. Epub 2003 Sep 23.


Sequences located 3' to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal A gamma-globin gene in transgenic mice.

Anagnou NP, Perez-Stable C, Gelinas R, Costantini F, Liapaki K, Constantopoulou M, Kosteas T, Moschonas NK, Stamatoyannopoulos G.

J Biol Chem. 1995 Apr 28;270(17):10256-63.


The human beta-globin locus control region confers an early embryonic erythroid-specific expression pattern to a basic promoter driving the bacterial lacZ gene.

Tewari R, Gillemans N, Harper A, Wijgerde M, Zafarana G, Drabek D, Grosveld F, Philipsen S.

Development. 1996 Dec;122(12):3991-9.


Adeno-associated virus 2-mediated transduction and erythroid lineage-restricted expression from parvovirus B19p6 promoter in primary human hematopoietic progenitor cells.

Kurpad C, Mukherjee P, Wang XS, Ponnazhagan S, Li L, Yoder MC, Srivastava A.

J Hematother Stem Cell Res. 1999 Dec;8(6):585-92.


Substitution of the human beta-spectrin promoter for the human agamma-globin promoter prevents silencing of a linked human beta-globin gene in transgenic mice.

Sabatino DE, Cline AP, Gallagher PG, Garrett LJ, Stamatoyannopoulos G, Forget BG, Bodine DM.

Mol Cell Biol. 1998 Nov;18(11):6634-40.


Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

Bungert J, Davé U, Lim KC, Lieuw KH, Shavit JA, Liu Q, Engel JD.

Genes Dev. 1995 Dec 15;9(24):3083-96.


Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.

Xiang P, Han H, Barkess G, Olave I, Fang X, Yin W, Stamatoyannopoulos G, Li Q.

Hum Mol Genet. 2005 Oct 15;14(20):3047-56. Epub 2005 Sep 9.


5'HS5 of the human beta-globin locus control region is dispensable for the formation of the beta-globin active chromatin hub.

Chan PK, Wai A, Philipsen S, Tan-Un KC.

PLoS One. 2008 May 7;3(5):e2134. doi: 10.1371/journal.pone.0002134.


CTCF-dependent enhancer-blocking by alternative chromatin loop formation.

Hou C, Zhao H, Tanimoto K, Dean A.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20398-403. doi: 10.1073/pnas.0808506106. Epub 2008 Dec 12.

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