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Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.

Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA.

Mol Biol Cell. 2003 Aug;14(8):3216-29. Epub 2003 Apr 17.


Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility.

Wang W, Liu Y, Liao K.

BMC Cell Biol. 2011 Nov 13;12:49. doi: 10.1186/1471-2121-12-49.


Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.

Kelley LC, Hayes KE, Ammer AG, Martin KH, Weed SA.

PLoS One. 2010 Nov 4;5(11):e13847. doi: 10.1371/journal.pone.0013847.


Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase.

Fan L, Di Ciano-Oliveira C, Weed SA, Craig AW, Greer PA, Rotstein OD, Kapus A.

Biochem J. 2004 Jun 1;380(Pt 2):581-91.


Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial cells.

Vouret-Craviari V, Bourcier C, Boulter E, van Obberghen-Schilling E.

J Cell Sci. 2002 Jun 15;115(Pt 12):2475-84.


Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin.

Hattan D, Nesti E, Cachero TG, Morielli AD.

J Biol Chem. 2002 Oct 11;277(41):38596-606. Epub 2002 Jul 31.


Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation.

Huang C, Ni Y, Wang T, Gao Y, Haudenschild CC, Zhan X.

J Biol Chem. 1997 May 23;272(21):13911-5.


The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation.

Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S.

EMBO J. 2003 Feb 3;22(3):515-28.


Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src.

Chen XM, Huang BQ, Splinter PL, Cao H, Zhu G, McNiven MA, LaRusso NF.

Gastroenterology. 2003 Jul;125(1):216-28.


Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex.

Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT.

J Cell Biol. 2000 Oct 2;151(1):29-40.


Cell volume-dependent phosphorylation of proteins of the cortical cytoskeleton and cell-cell contact sites. The role of Fyn and FER kinases.

Kapus A, Di Ciano C, Sun J, Zhan X, Kim L, Wong TW, Rotstein OD.

J Biol Chem. 2000 Oct 13;275(41):32289-98.


Cortactin: coupling membrane dynamics to cortical actin assembly.

Weed SA, Parsons JT.

Oncogene. 2001 Oct 1;20(44):6418-34. Review.


Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

Oser M, Mader CC, Gil-Henn H, Magalhaes M, Bravo-Cordero JJ, Koleske AJ, Condeelis J.

J Cell Sci. 2010 Nov 1;123(Pt 21):3662-73. doi: 10.1242/jcs.068163.


Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency.

Crowley JL, Smith TC, Fang Z, Takizawa N, Luna EJ.

Mol Biol Cell. 2009 Feb;20(3):948-62. doi: 10.1091/mbc.E08-08-0867. Epub 2008 Dec 24.


Thrombopoietin stimulates cortactin translocation to the cytoskeleton independently of tyrosine phosphorylation.

Lopez I, Duprez V, Melle J, Dreyfus F, Lévy-Tolédano S, Fontenay-Roupie M.

Biochem J. 2001 Jun 15;356(Pt 3):875-81.


Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes.

Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, Torrisi MR, Mancini P.

Exp Cell Res. 2007 May 15;313(9):1758-77. Epub 2007 Mar 24.


Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP.

Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS.

Mol Cell Biol. 2004 Jun;24(12):5269-80.

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