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Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling.

Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt-Clermont P, Kovacic H.

Mol Cell Biol. 2003 Aug;23(15):5401-8.


Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism.

Armstrong LC, Björkblom B, Hankenson KD, Siadak AW, Stiles CE, Bornstein P.

Mol Biol Cell. 2002 Jun;13(6):1893-905.


Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase.

Groth S, Schulze M, Kalthoff H, Fändrich F, Ungefroren H.

J Biol Chem. 2005 Sep 30;280(39):33190-9. Epub 2005 Jul 28.


Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in human aortic endothelial cells stimulated by histamine.

Hu Q, Yu ZX, Ferrans VJ, Takeda K, Irani K, Ziegelstein RC.

J Biol Chem. 2002 Sep 6;277(36):32546-51. Epub 2002 Jul 1.


Pitavastatin inhibits lysophosphatidic acid-induced proliferation and monocyte chemoattractant protein-1 expression in aortic smooth muscle cells by suppressing Rac-1-mediated reactive oxygen species generation.

Kaneyuki U, Ueda S, Yamagishi S, Kato S, Fujimura T, Shibata R, Hayashida A, Yoshimura J, Kojiro M, Oshima K, Okuda S.

Vascul Pharmacol. 2007 Apr;46(4):286-92. Epub 2006 Nov 14.


Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells.

Kovacic HN, Irani K, Goldschmidt-Clermont PJ.

J Biol Chem. 2001 Dec 7;276(49):45856-61. Epub 2001 Oct 3.


NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle.

Brar SS, Kennedy TP, Sturrock AB, Huecksteadt TP, Quinn MT, Murphy TM, Chitano P, Hoidal JR.

Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L782-95.


Phosphatidylinositol 3-kinase-dependent membrane recruitment of Rac-1 and p47phox is critical for alpha-platelet-derived growth factor receptor-induced production of reactive oxygen species.

Bäumer AT, Ten Freyhaus H, Sauer H, Wartenberg M, Kappert K, Schnabel P, Konkol C, Hescheler J, Vantler M, Rosenkranz S.

J Biol Chem. 2008 Mar 21;283(12):7864-76. Epub 2007 Dec 10.


C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells.

Cifarelli V, Geng X, Styche A, Lakomy R, Trucco M, Luppi P.

Diabetologia. 2011 Oct;54(10):2702-12. doi: 10.1007/s00125-011-2251-0. Epub 2011 Jul 20.


RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species.

Manickam N, Patel M, Griendling KK, Gorin Y, Barnes JL.

Am J Physiol Renal Physiol. 2014 Jul 15;307(2):F159-71. doi: 10.1152/ajprenal.00546.2013. Epub 2014 May 28.


Characterization of a Rac1 signaling pathway to cyclin D(1) expression in airway smooth muscle cells.

Page K, Li J, Hodge JA, Liu PT, Vanden Hoek TL, Becker LB, Pestell RG, Rosner MR, Hershenson MB.

J Biol Chem. 1999 Jul 30;274(31):22065-71.


Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.

Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR.

J Biol Chem. 2015 Jan 2;290(1):409-22. doi: 10.1074/jbc.M114.618421. Epub 2014 Nov 11.


Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.

Diebold I, Djordjevic T, Petry A, Hatzelmann A, Tenor H, Hess J, Görlach A.

Circ Res. 2009 May 22;104(10):1169-77. doi: 10.1161/CIRCRESAHA.109.196592. Epub 2009 Apr 23.


Rac upregulates tissue inhibitor of metalloproteinase-1 expression by redox-dependent activation of extracellular signal-regulated kinase signaling.

Engers R, Springer E, Kehren V, Simic T, Young DA, Beier J, Klotz LO, Clark IM, Sies H, Gabbert HE.

FEBS J. 2006 Oct;273(20):4754-69. Epub 2006 Sep 19.


Role of redox signaling and poly (adenosine diphosphate-ribose) polymerase activation in vascular smooth muscle cell growth inhibition by nitric oxide and peroxynitrite.

Huang J, Lin SC, Nadershahi A, Watts SW, Sarkar R.

J Vasc Surg. 2008 Mar;47(3):599-607. doi: 10.1016/j.jvs.2007.11.006.


Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene.

Wang PL, Niidome T, Akaike A, Kihara T, Sugimoto H.

J Neurosci Res. 2009 Jul;87(9):2105-14. doi: 10.1002/jnr.22039.


Human thrombospondin 2 inhibits proliferation of microvascular endothelial cells.

Tomii Y, Kamochi J, Yamazaki H, Sawa N, Tokunaga T, Ohnishi Y, Kijima H, Ueyama Y, Tamaoki N, Nakamura M.

Int J Oncol. 2002 Feb;20(2):339-42.


TNF-alpha/cycloheximide-induced apoptosis in intestinal epithelial cells requires Rac1-regulated reactive oxygen species.

Jin S, Ray RM, Johnson LR.

Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G928-37. doi: 10.1152/ajpgi.00219.2007. Epub 2008 Jan 24.


Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species.

Cho HJ, Jeong HG, Lee JS, Woo ER, Hyun JW, Chung MH, You HJ.

J Biol Chem. 2002 May 31;277(22):19358-66. Epub 2002 Mar 7.

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