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Items: 1 to 20 of 68

1.

High-content assays for ligand regulation of G-protein-coupled receptors.

Milligan G.

Drug Discov Today. 2003 Jul 1;8(13):579-85. Review.

PMID:
12850333
2.

Maximizing serendipity: strategies for identifying ligands for orphan G-protein-coupled receptors.

Robas N, O'Reilly M, Katugampola S, Fidock M.

Curr Opin Pharmacol. 2003 Apr;3(2):121-6. Review.

PMID:
12681232
3.

G protein-coupled receptor internalization assays in the high-content screening format.

Haasen D, Schnapp A, Valler MJ, Heilker R.

Methods Enzymol. 2006;414:121-39.

PMID:
17110190
4.

Uncovering biases in high throughput screens of G-protein coupled receptors.

Woolf PJ, Kenakin TP, Linderman JJ.

J Theor Biol. 2001 Feb 21;208(4):403-18.

PMID:
11222046
5.
6.

Allosteric modulators of G-protein-coupled receptors.

May LT, Christopoulos A.

Curr Opin Pharmacol. 2003 Oct;3(5):551-6. Review.

PMID:
14559102
7.
8.

Chimaeric G alpha proteins: their potential use in drug discovery.

Milligan G, Rees S.

Trends Pharmacol Sci. 1999 Mar;20(3):118-24. Review. Erratum in: Trends Pharmacol Sci 1999 Jun;20(6):252.

PMID:
10203868
9.

Allosteric agonist modulators.

Kenakin T.

J Recept Signal Transduct Res. 2007;27(4):247-59.

PMID:
17885921
10.

Analysis of function of receptor-G-protein and receptor-RGS fusion proteins.

Ward RJ, Milligan G.

Methods Mol Biol. 2004;259:225-47.

PMID:
15250496
11.

Predicting therapeutic value in the lead optimization phase of drug discovery.

Kenakin T.

Nat Rev Drug Discov. 2003 Jun;2(6):429-38. Review.

PMID:
12776218
12.

Affinity selection-mass spectrometry and its emerging application to the high throughput screening of G protein-coupled receptors.

Whitehurst CE, Annis DA.

Comb Chem High Throughput Screen. 2008 Jul;11(6):427-38. Review.

PMID:
18673271
13.

Functional analysis of cell-free-produced human endothelin B receptor reveals transmembrane segment 1 as an essential area for ET-1 binding and homodimer formation.

Klammt C, Srivastava A, Eifler N, Junge F, Beyermann M, Schwarz D, Michel H, Doetsch V, Bernhard F.

FEBS J. 2007 Jul;274(13):3257-69. Epub 2007 May 29.

14.
15.

New strategies in drug discovery for GPCRs: high throughput detection of cellular ERK phosphorylation.

Crouch MF, Osmond RI.

Comb Chem High Throughput Screen. 2008 Jun;11(5):344-56.

PMID:
18537556
16.

Emerging trends in high-throughput screening.

Entzeroth M.

Curr Opin Pharmacol. 2003 Oct;3(5):522-9. Review.

PMID:
14559099
17.
18.

Confocal fluorescence microscopy for high-throughput screening of G-protein coupled receptors.

Heilker R, Zemanova L, Valler MJ, Nienhaus GU.

Curr Med Chem. 2005;12(22):2551-9. Review.

PMID:
16248815
19.

Use of high-content analysis for compound screening and target selection.

Rausch O.

IDrugs. 2005 Jul;8(7):573-7. Review.

PMID:
15973566
20.

G protein-coupled receptor microarrays for drug discovery.

Fang Y, Lahiri J, Picard L.

Drug Discov Today. 2003 Aug 15;8(16):755-61. Review.

PMID:
12944098

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