Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 216

1.

TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver.

Du K, Herzig S, Kulkarni RN, Montminy M.

Science. 2003 Jun 6;300(5625):1574-7.

2.

Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice.

Shao J, Yamashita H, Qiao L, Friedman JE.

J Endocrinol. 2000 Oct;167(1):107-15.

3.

Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice.

Lima AF, Ropelle ER, Pauli JR, Cintra DE, Frederico MJ, Pinho RA, Velloso LA, De Souza CT.

J Cell Physiol. 2009 Oct;221(1):92-7. doi: 10.1002/jcp.21833.

PMID:
19492410
4.

APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice.

Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A.

Cell Metab. 2009 May;9(5):417-27. doi: 10.1016/j.cmet.2009.03.013.

5.

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

Dickson LM, Lingohr MK, McCuaig J, Hugl SR, Snow L, Kahn BB, Myers MG Jr, Rhodes CJ.

J Biol Chem. 2001 Jun 15;276(24):21110-20. Epub 2001 Mar 27.

6.

Genetic deletion of Trb3, the mammalian Drosophila tribbles homolog, displays normal hepatic insulin signaling and glucose homeostasis.

Okamoto H, Latres E, Liu R, Thabet K, Murphy A, Valenzeula D, Yancopoulos GD, Stitt TN, Glass DJ, Sleeman MW.

Diabetes. 2007 May;56(5):1350-6. Epub 2007 Feb 15.

8.

Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes.

Yamada T, Katagiri H, Asano T, Tsuru M, Inukai K, Ono H, Kodama T, Kikuchi M, Oka Y.

Am J Physiol Endocrinol Metab. 2002 Jun;282(6):E1385-94.

9.

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

Viniegra JG, Martínez N, Modirassari P, Hernández Losa J, Parada Cobo C, Sánchez-Arévalo Lobo VJ, Aceves Luquero CI, Alvarez-Vallina L, Ramón y Cajal S, Rojas JM, Sánchez-Prieto R.

J Biol Chem. 2005 Feb 11;280(6):4029-36. Epub 2004 Nov 15.

10.

Endurance exercise training increases APPL1 expression and improves insulin signaling in the hepatic tissue of diet-induced obese mice, independently of weight loss.

Marinho R, Ropelle ER, Cintra DE, De Souza CT, Da Silva AS, Bertoli FC, Colantonio E, D'Almeida V, Pauli JR.

J Cell Physiol. 2012 Jul;227(7):2917-26. doi: 10.1002/jcp.23037.

PMID:
21938726
11.

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M.

Nat Med. 2004 May;10(5):530-4. Epub 2004 Apr 25. Erratum in: Nat Med. 2004 Jul;7(10):755.

PMID:
15107844
12.

Hyperglycemia impairs the insulin signaling step between PI 3-kinase and Akt/PKB activations in ZDF rat liver.

Nawano M, Ueta K, Oku A, Arakawa K, Saito A, Funaki M, Anai M, Kikuchi M, Oka Y, Asano T.

Biochem Biophys Res Commun. 1999 Dec 9;266(1):252-6.

PMID:
10581198
13.

Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes.

Sakaue H, Nishizawa A, Ogawa W, Teshigawara K, Mori T, Takashima Y, Noda T, Kasuga M.

J Biol Chem. 2003 Oct 3;278(40):38870-4. Epub 2003 Jul 10.

14.

Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.

Lingohr MK, Dickson LM, McCuaig JF, Hugl SR, Twardzik DR, Rhodes CJ.

Diabetes. 2002 Apr;51(4):966-76.

15.

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.

Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG.

J Clin Invest. 2003 Jul;112(2):197-208. Epub 2003 Jul 3.

16.

Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes.

Brutman-Barazani T, Horovitz-Fried M, Aga-Mizrachi S, Brand C, Brodie C, Rosa J, Sampson SR.

J Cell Biochem. 2012 Jun;113(6):2064-76. doi: 10.1002/jcb.24078.

PMID:
22271577
17.

Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor gamma and retinoic acid X receptors.

Li X, Hansen PA, Xi L, Chandraratna RA, Burant CF.

J Biol Chem. 2005 Nov 18;280(46):38317-27. Epub 2005 Sep 22.

18.

Inhibitory effect of hyperglycemia on insulin-induced Akt/protein kinase B activation in skeletal muscle.

Oku A, Nawano M, Ueta K, Fujita T, Umebayashi I, Arakawa K, Kano-Ishihara T, Saito A, Anai M, Funaki M, Kikuchi M, Oka Y, Asano T.

Am J Physiol Endocrinol Metab. 2001 May;280(5):E816-24.

19.

ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells.

Halaby MJ, Hibma JC, He J, Yang DQ.

Cell Signal. 2008 Aug;20(8):1555-63. doi: 10.1016/j.cellsig.2008.04.011. Epub 2008 Apr 26.

PMID:
18534819
20.

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure.

Mora A, Lipina C, Tronche F, Sutherland C, Alessi DR.

Biochem J. 2005 Feb 1;385(Pt 3):639-48.

Supplemental Content

Support Center