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Items: 1 to 20 of 147

1.

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.

Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J.

J Biol Chem. 2003 Aug 15;278(33):30772-80. Epub 2003 Jun 3.

2.

Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity.

Tiainen P, Myllyharju J, Koivunen P.

J Biol Chem. 2005 Jan 14;280(2):1142-8. Epub 2004 Nov 4.

3.

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Günzler V, Kivirikko KI, Myllyharju J.

J Biol Chem. 2004 Mar 12;279(11):9899-904. Epub 2003 Dec 29.

4.

An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.

Koivunen P, Tiainen P, Hyvärinen J, Williams KE, Sormunen R, Klaus SJ, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Oct 19;282(42):30544-52. Epub 2007 Aug 27.

6.

A conserved family of prolyl-4-hydroxylases that modify HIF.

Bruick RK, McKnight SL.

Science. 2001 Nov 9;294(5545):1337-40. Epub 2001 Oct 11.

7.

The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases.

Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J.

J Biol Chem. 2006 Sep 29;281(39):28712-20. Epub 2006 Aug 1.

8.

Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor.

Appelhoff RJ, Tian YM, Raval RR, Turley H, Harris AL, Pugh CW, Ratcliffe PJ, Gleadle JM.

J Biol Chem. 2004 Sep 10;279(37):38458-65. Epub 2004 Jul 7.

10.

Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.

Aro E, Khatri R, Gerard-O'Riley R, Mangiavini L, Myllyharju J, Schipani E.

J Biol Chem. 2012 Oct 26;287(44):37134-44. doi: 10.1074/jbc.M112.352872. Epub 2012 Aug 28.

11.
12.

HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.

13.

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Feb 16;282(7):4524-32. Epub 2006 Dec 19.

14.

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles.

Myllyharju J, Koivunen P.

Biol Chem. 2013 Apr;394(4):435-48. doi: 10.1515/hsz-2012-0328. Review.

PMID:
23324380
15.

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.

Tuckerman JR, Zhao Y, Hewitson KS, Tian YM, Pugh CW, Ratcliffe PJ, Mole DR.

FEBS Lett. 2004 Oct 8;576(1-2):145-50.

16.

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.

Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.

J Cell Biochem. 2004 Jun 1;92(3):491-501. Erratum in: J Cell Biochem. 2004 Oct 15;93(3):639.

PMID:
15156561
17.

Activation of hypoxia-induced transcription in normoxia.

Hägg M, Wennström S.

Exp Cell Res. 2005 May 15;306(1):180-91. Epub 2005 Mar 19.

PMID:
15878343
18.

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ, Ratcliffe PJ.

Cell. 2001 Oct 5;107(1):43-54.

19.

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.

D'Angelo G, Duplan E, Boyer N, Vigne P, Frelin C.

J Biol Chem. 2003 Oct 3;278(40):38183-7. Epub 2003 Jul 21.

20.

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

Huang J, Zhao Q, Mooney SM, Lee FS.

J Biol Chem. 2002 Oct 18;277(42):39792-800. Epub 2002 Aug 13.

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