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Microbial isoprenoid biosynthesis and human gammadelta T cell activation.

Eberl M, Hintz M, Reichenberg A, Kollas AK, Wiesner J, Jomaa H.

FEBS Lett. 2003 Jun 5;544(1-3):4-10. Review.


The interplay between classical and alternative isoprenoid biosynthesis controls gammadelta T cell bioactivity of Listeria monocytogenes.

Begley M, Gahan CG, Kollas AK, Hintz M, Hill C, Jomaa H, Eberl M.

FEBS Lett. 2004 Mar 12;561(1-3):99-104.


Identification of (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate as a major activator for human gammadelta T cells in Escherichia coli.

Hintz M, Reichenberg A, Altincicek B, Bahr U, Gschwind RM, Kollas AK, Beck E, Wiesner J, Eberl M, Jomaa H.

FEBS Lett. 2001 Dec 7;509(2):317-22.


Stimulation of Vgamma9/Vdelta2 T-lymphocyte proliferation by the isoprenoid precursor, (E)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate.

Amslinger S, Hecht S, Rohdich F, Eisenreich W, Adam P, Bacher A, Bauer S.

Immunobiology. 2007;212(1):47-55. Epub 2006 Sep 18.


Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

Correia DV, d'Orey F, Cardoso BA, Lança T, Grosso AR, deBarros A, Martins LR, Barata JT, Silva-Santos B.

PLoS One. 2009 May 21;4(5):e5657. doi: 10.1371/journal.pone.0005657.


Vgamma9/Vdelta2 T cell activation induced by bacterial low molecular mass compounds depends on the 1-deoxy-D-xylulose 5-phosphate pathway of isoprenoid biosynthesis.

Jomaa H, Feurle J, Lühs K, Kunzmann V, Tony HP, Herderich M, Wilhelm M.

FEMS Immunol Med Microbiol. 1999 Sep;25(4):371-8.


Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1).

Eberl M, Engel R, Aberle S, Fisch P, Jomaa H, Pircher H.

J Leukoc Biol. 2005 Jan;77(1):67-70. Epub 2004 Oct 21.


IL-21 enhances the potential of human γδ T cells to provide B-cell help.

Bansal RR, Mackay CR, Moser B, Eberl M.

Eur J Immunol. 2012 Jan;42(1):110-9. doi: 10.1002/eji.201142017. Epub 2011 Dec 12.


Accumulation of a potent gammadelta T-cell stimulator after deletion of the lytB gene in Escherichia coli.

Eberl M, Altincicek B, Kollas AK, Sanderbrand S, Bahr U, Reichenberg A, Beck E, Foster D, Wiesner J, Hintz M, Jomaa H.

Immunology. 2002 Jun;106(2):200-11.


Monocytes and gammadelta T cells: close encounters in microbial infection.

Eberl M, Moser B.

Trends Immunol. 2009 Dec;30(12):562-8. doi: 10.1016/ Epub 2009 Oct 21.


Escherichia coli produces phosphoantigens activating human gamma delta T cells.

Feurle J, Espinosa E, Eckstein S, Pont F, Kunzmann V, Fournié JJ, Herderich M, Wilhelm M.

J Biol Chem. 2002 Jan 4;277(1):148-54. Epub 2001 Oct 23.


Non-peptide antigens activating human Vgamma9/Vdelta2 T lymphocytes.

Poupot M, Fournié JJ.

Immunol Lett. 2004 Sep;95(2):129-38. Review.


Replacing the pyrophosphate group of HMB-PP by a diphosphonate function abrogates Its potential to activate human gammadelta T cells but does not lead to competitive antagonism.

Reichenberg A, Hintz M, Kletschek Y, Kuhl T, Haug C, Engel R, Moll J, Ostrovsky DN, Jomaa H, Eberl M.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1257-60.


Human neutrophil clearance of bacterial pathogens triggers anti-microbial γδ T cell responses in early infection.

Davey MS, Lin CY, Roberts GW, Heuston S, Brown AC, Chess JA, Toleman MA, Gahan CG, Hill C, Parish T, Williams JD, Davies SJ, Johnson DW, Topley N, Moser B, Eberl M.

PLoS Pathog. 2011 May;7(5):e1002040. doi: 10.1371/journal.ppat.1002040. Epub 2011 May 12.


Cutting edge: human gamma delta T cells are activated by intermediates of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis.

Altincicek B, Moll J, Campos N, Foerster G, Beck E, Hoeffler JF, Grosdemange-Billiard C, Rodríguez-Concepción M, Rohmer M, Boronat A, Eberl M, Jomaa H.

J Immunol. 2001 Mar 15;166(6):3655-8.


The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathways.

Guzy C, Paclik D, Schirbel A, Sonnenborn U, Wiedenmann B, Sturm A.

Int Immunol. 2008 Jul;20(7):829-40. doi: 10.1093/intimm/dxn041. Epub 2008 Apr 30.


Activation of human γδ T cells by cytosolic interactions of BTN3A1 with soluble phosphoantigens and the cytoskeletal adaptor periplakin.

Rhodes DA, Chen HC, Price AJ, Keeble AH, Davey MS, James LC, Eberl M, Trowsdale J.

J Immunol. 2015 Mar 1;194(5):2390-8. doi: 10.4049/jimmunol.1401064. Epub 2015 Jan 30.


Synthesis of analogues of (E)-1-hydroxy-2-methylbut-2-enyl 4-diphosphate, an isoprenoid precursor and human gamma delta T cell activator.

Van Hoof S, Lacey CJ, Röhrich RC, Wiesner J, Jomaa H, Van Calenbergh S.

J Org Chem. 2008 Feb 15;73(4):1365-70. doi: 10.1021/jo701873t. Epub 2008 Jan 23.


Activation of V gamma 9V delta 2 T cells by NKG2D.

Rincon-Orozco B, Kunzmann V, Wrobel P, Kabelitz D, Steinle A, Herrmann T.

J Immunol. 2005 Aug 15;175(4):2144-51.


Preferential recognition of a microbial metabolite by human Vgamma2Vdelta2 T cells.

Puan KJ, Jin C, Wang H, Sarikonda G, Raker AM, Lee HK, Samuelson MI, Märker-Hermann E, Pasa-Tolic L, Nieves E, Giner JL, Kuzuyama T, Morita CT.

Int Immunol. 2007 May;19(5):657-73. Epub 2007 Apr 19.


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