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Items: 1 to 20 of 343

1.

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation.

Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL.

Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4389-94. Epub 2003 Apr 3.

2.

HDAC6 is a microtubule-associated deacetylase.

Hubbert C, Guardiola A, Shao R, Kawaguchi Y, Ito A, Nixon A, Yoshida M, Wang XF, Yao TP.

Nature. 2002 May 23;417(6887):455-8.

PMID:
12024216
4.

Regulation of microtubule dynamics by inhibition of the tubulin deacetylase HDAC6.

Zilberman Y, Ballestrem C, Carramusa L, Mazitschek R, Khochbin S, Bershadsky A.

J Cell Sci. 2009 Oct 1;122(Pt 19):3531-41. doi: 10.1242/jcs.046813. Epub 2009 Sep 8.

5.

The histone deacetylase-6 inhibitor tubacin directly inhibits de novo sphingolipid biosynthesis as an off-target effect.

Siow D, Wattenberg B.

Biochem Biophys Res Commun. 2014 Jul 4;449(3):268-71. doi: 10.1016/j.bbrc.2014.05.016. Epub 2014 May 14.

PMID:
24835950
6.

Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells.

Asthana J, Kapoor S, Mohan R, Panda D.

J Biol Chem. 2013 Aug 2;288(31):22516-26. doi: 10.1074/jbc.M113.489328. Epub 2013 Jun 24.

7.

Lymphocyte chemotaxis is regulated by histone deacetylase 6, independently of its deacetylase activity.

Cabrero JR, Serrador JM, Barreiro O, Mittelbrunn M, Naranjo-Suárez S, Martín-Cófreces N, Vicente-Manzanares M, Mazitschek R, Bradner JE, Avila J, Valenzuela-Fernández A, Sánchez-Madrid F.

Mol Biol Cell. 2006 Aug;17(8):3435-45. Epub 2006 May 31.

8.

Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases.

Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S.

J Biol Chem. 2004 Feb 27;279(9):7685-91. Epub 2003 Dec 10.

9.

Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation.

Zhang D, Wu CT, Qi X, Meijering RA, Hoogstra-Berends F, Tadevosyan A, Cubukcuoglu Deniz G, Durdu S, Akar AR, Sibon OC, Nattel S, Henning RH, Brundel BJ.

Circulation. 2014 Jan 21;129(3):346-58. doi: 10.1161/CIRCULATIONAHA.113.005300. Epub 2013 Oct 21.

10.

Clostridium difficile toxin A decreases acetylation of tubulin, leading to microtubule depolymerization through activation of histone deacetylase 6, and this mediates acute inflammation.

Nam HJ, Kang JK, Kim SK, Ahn KJ, Seok H, Park SJ, Chang JS, Pothoulakis C, Lamont JT, Kim H.

J Biol Chem. 2010 Oct 22;285(43):32888-96. doi: 10.1074/jbc.M110.162743. Epub 2010 Aug 9.

11.

TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6.

Tokési N, Lehotzky A, Horváth I, Szabó B, Oláh J, Lau P, Ovádi J.

J Biol Chem. 2010 Jun 4;285(23):17896-906. doi: 10.1074/jbc.M109.096578. Epub 2010 Mar 22.

12.

Significance of HDAC6 regulation via estrogen signaling for cell motility and prognosis in estrogen receptor-positive breast cancer.

Saji S, Kawakami M, Hayashi S, Yoshida N, Hirose M, Horiguchi S, Itoh A, Funata N, Schreiber SL, Yoshida M, Toi M.

Oncogene. 2005 Jun 30;24(28):4531-9.

PMID:
15806142
13.

LC3B-II deacetylation by histone deacetylase 6 is involved in serum-starvation-induced autophagic degradation.

Liu KP, Zhou D, Ouyang DY, Xu LH, Wang Y, Wang LX, Pan H, He XH.

Biochem Biophys Res Commun. 2013 Nov 29;441(4):970-5. doi: 10.1016/j.bbrc.2013.11.007. Epub 2013 Nov 9.

PMID:
24220335
14.

Histone deacetylase 6 (HDAC6) is an independent deacetylase for alpha-tubulin.

Zhao Z, Xu H, Gong W.

Protein Pept Lett. 2010 May;17(5):555-8.

PMID:
19961433
15.

Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, Ikeda AK, Hsieh YT, Kim YM, Lomenick B, Okemoto K, Landaw EM, Wang D, Mazitschek R, Bradner JE, Sakamoto KM.

Leuk Lymphoma. 2011 Aug;52(8):1544-55. doi: 10.3109/10428194.2011.570821. Epub 2011 Jun 23.

16.

Tau--an inhibitor of deacetylase HDAC6 function.

Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J.

J Neurochem. 2009 Jun;109(6):1756-66. doi: 10.1111/j.1471-4159.2009.06102.x. Epub 2009 May 7.

17.

Histone deacetylase 6 interacts with the microtubule-associated protein tau.

Ding H, Dolan PJ, Johnson GV.

J Neurochem. 2008 Sep;106(5):2119-30. doi: 10.1111/j.1471-4159.2008.05564.x. Epub 2008 Jul 12.

18.

HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes.

Noack M, Leyk J, Richter-Landsberg C.

Glia. 2014 Apr;62(4):535-47. doi: 10.1002/glia.22624. Epub 2014 Jan 24.

PMID:
24464872
19.

Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally.

Zhang Y, Kwon S, Yamaguchi T, Cubizolles F, Rousseaux S, Kneissel M, Cao C, Li N, Cheng HL, Chua K, Lombard D, Mizeracki A, Matthias G, Alt FW, Khochbin S, Matthias P.

Mol Cell Biol. 2008 Mar;28(5):1688-701. doi: 10.1128/MCB.01154-06. Epub 2008 Jan 7.

20.

A novel method for purification of polymerizable tubulin with a high content of the acetylated isotype.

Carbajal A, Chesta ME, Bisig CG, Arce CA.

Biochem J. 2013 Feb 1;449(3):643-8. doi: 10.1042/BJ20121439.

PMID:
23140207

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