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The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis.

Chen S, Yin X, Zhu X, Yan J, Ji S, Chen C, Cai M, Zhang S, Zong H, Hu Y, Yuan Z, Shen Z, Gu J.

J Biol Chem. 2003 May 30;278(22):20029-36. Epub 2003 Mar 6.


Identification of dynein light chain 2 as an interaction partner of p21-activated kinase 1.

Lu J, Sun Q, Chen X, Wang H, Hu Y, Gu J.

Biochem Biophys Res Commun. 2005 May 27;331(1):153-8.


Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD.

Chen C, Yan J, Sun Q, Yao L, Jian Y, Lu J, Gu J.

FEBS Lett. 2006 Feb 6;580(3):813-21. Epub 2006 Jan 10.


PITSLRE protein kinase activity is associated with apoptosis.

Lahti JM, Xiang J, Heath LS, Campana D, Kidd VJ.

Mol Cell Biol. 1995 Jan;15(1):1-11.


Evidence that 12-lipoxygenase product 12-hydroxyeicosatetraenoic acid activates p21-activated kinase.

Wen Y, Gu J, Knaus UG, Thomas L, Gonzales N, Nadler JL.

Biochem J. 2000 Jul 15;349(Pt 2):481-7.


Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis.

Menard RE, Jovanovski AP, Mattingly RR.

Neoplasia. 2005 Jul;7(7):638-45.


Hepatitis B virus X protein confers resistance of hepatoma cells to anoikis by up-regulating and activating p21-activated kinase 1.

Xu J, Liu H, Chen L, Wang S, Zhou L, Yun X, Sun L, Wen Y, Gu J.

Gastroenterology. 2012 Jul;143(1):199-212.e4. doi: 10.1053/j.gastro.2012.03.053. Epub 2012 Apr 5.


Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis induced by benzo[a]pyrene.

Yoshii S, Tanaka M, Otsuki Y, Fujiyama T, Kataoka H, Arai H, Hanai H, Sugimura H.

Mol Cell Biol. 2001 Oct;21(20):6796-807.


ArgBP2gamma interacts with Akt and p21-activated kinase-1 and promotes cell survival.

Yuan ZQ, Kim D, Kaneko S, Sussman M, Bokoch GM, Kruh GD, Nicosia SV, Testa JR, Cheng JQ.

J Biol Chem. 2005 Jun 3;280(22):21483-90. Epub 2005 Mar 22. Retraction in: J Biol Chem. 2016 Oct 21;291(43):22845.


Autophosphorylation-dependent degradation of Pak1, triggered by the Rho-family GTPase, Chp.

Weisz Hubsman M, Volinsky N, Manser E, Yablonski D, Aronheim A.

Biochem J. 2007 Jun 15;404(3):487-97.


p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

King CC, Gardiner EM, Zenke FT, Bohl BP, Newton AC, Hemmings BA, Bokoch GM.

J Biol Chem. 2000 Dec 29;275(52):41201-9.


N-acetylglucosaminyltransferase V confers hepatoma cells with resistance to anoikis through EGFR/PAK1 activation.

Liu J, Liu H, Zhang W, Wu Q, Liu W, Liu Y, Pan D, Xu J, Gu J.

Glycobiology. 2013 Sep;23(9):1097-109. doi: 10.1093/glycob/cwt049. Epub 2013 Jun 27.


Interaction of p58(PITSLRE), a G2/M-specific protein kinase, with cyclin D3.

Zhang S, Cai M, Zhang S, Xu S, Chen S, Chen X, Chen C, Gu J.

J Biol Chem. 2002 Sep 20;277(38):35314-22. Epub 2002 Jun 24.


Klotho endows hepatoma cells with resistance to anoikis via VEGFR2/PAK1 activation in hepatocellular carcinoma.

Chen L, Liu H, Liu J, Zhu Y, Xu L, He H, Zhang H, Wang S, Wu Q, Liu W, Liu Y, Pan D, Ren S, Xu J, Gu J.

PLoS One. 2013;8(3):e58413. doi: 10.1371/journal.pone.0058413. Epub 2013 Mar 13.


The PITSLRE protein kinase family.

Lahti JM, Xiang J, Kidd VJ.

Prog Cell Cycle Res. 1995;1:329-38. Review.


Analysis of small GTPase signaling pathways using p21-activated kinase mutants that selectively couple to Cdc42.

Reeder MK, Serebriiskii IG, Golemis EA, Chernoff J.

J Biol Chem. 2001 Nov 2;276(44):40606-13. Epub 2001 Aug 20.


p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells.

Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R.

EMBO Rep. 2002 Aug;3(8):767-73. Epub 2002 Jul 15.


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