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Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control.

Lou Z, Chini CC, Minter-Dykhouse K, Chen J.

J Biol Chem. 2003 Apr 18;278(16):13599-602. Epub 2003 Feb 27.


MDC1 regulates DNA-PK autophosphorylation in response to DNA damage.

Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J.

J Biol Chem. 2004 Nov 5;279(45):46359-62. Epub 2004 Sep 17.


MDC1 is a mediator of the mammalian DNA damage checkpoint.

Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ.

Nature. 2003 Feb 27;421(6926):961-6.


NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway.

Wilson KA, Stern DF.

Cell Cycle. 2008 Nov 15;7(22):3584-94. Epub 2008 Nov 29.


DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM.

Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD.

J Biol Chem. 2005 Apr 15;280(15):15158-64. Epub 2005 Feb 15.


MDC1 is required for the intra-S-phase DNA damage checkpoint.

Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, Bartek J, Jackson SP.

Nature. 2003 Feb 27;421(6926):952-6.


Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY.

Genes Dev. 2008 Mar 1;22(5):587-600. doi: 10.1101/gad.1627708. Epub 2008 Feb 18.


Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase.

Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D.

Science. 2007 Dec 7;318(5856):1637-40. Epub 2007 Nov 15.


STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage.

Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A.

J Cell Sci. 2005 Apr 15;118(Pt 8):1629-39. Epub 2005 Mar 22. Retraction in: J Cell Sci. 2015 Mar 1;128(5):1064.


MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes.

Stucki M, Jackson SP.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):953-7. Review.


NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites.

Ray A, Milum K, Battu A, Wani G, Wani AA.

DNA Repair (Amst). 2013 Apr 1;12(4):273-83. doi: 10.1016/j.dnarep.2013.01.003. Epub 2013 Feb 17.


BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.

Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK.

J Biol Chem. 2004 Jul 23;279(30):31251-8. Epub 2004 May 24.


Role for ATM in DNA damage-induced phosphorylation of BRCA1.

Gatei M, Scott SP, Filippovitch I, Soronika N, Lavin MF, Weber B, Khanna KK.

Cancer Res. 2000 Jun 15;60(12):3299-304.


ATM activation by ionizing radiation requires BRCA1-associated BAAT1.

Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T.

J Biol Chem. 2006 Apr 7;281(14):9710-8. Epub 2006 Feb 1.


NFBD1/Mdc1 mediates ATR-dependent DNA damage response.

Peng A, Chen PL.

Cancer Res. 2005 Feb 15;65(4):1158-63.


Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress.

Tibbetts RS, Cortez D, Brumbaugh KM, Scully R, Livingston D, Elledge SJ, Abraham RT.

Genes Dev. 2000 Dec 1;14(23):2989-3002.


Differing effects of breast cancer 1, early onset (BRCA1) and ataxia-telangiectasia mutated (ATM) mutations on cellular responses to ionizing radiation.

Mamon HJ, Dahlberg W, Azzam EI, Nagasawa H, Muto MG, Little JB.

Int J Radiat Biol. 2003 Oct;79(10):817-29.


Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.

Xu X, Lee J, Stern DF.

J Biol Chem. 2004 Aug 13;279(33):34091-4. Epub 2004 Jun 25.

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