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Items: 1 to 20 of 121

1.

Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function.

Snyder H, Mensah K, Theisler C, Lee J, Matouschek A, Wolozin B.

J Biol Chem. 2003 Apr 4;278(14):11753-9. Epub 2003 Jan 24.

2.

beta-Synuclein reduces proteasomal inhibition by alpha-synuclein but not gamma-synuclein.

Snyder H, Mensah K, Hsu C, Hashimoto M, Surgucheva IG, Festoff B, Surguchov A, Masliah E, Matouschek A, Wolozin B.

J Biol Chem. 2005 Mar 4;280(9):7562-9. Epub 2004 Dec 9.

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Proteasomal inhibition by alpha-synuclein filaments and oligomers.

Lindersson E, Beedholm R, Højrup P, Moos T, Gai W, Hendil KB, Jensen PH.

J Biol Chem. 2004 Mar 26;279(13):12924-34. Epub 2004 Jan 7.

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Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells.

Rideout HJ, Larsen KE, Sulzer D, Stefanis L.

J Neurochem. 2001 Aug;78(4):899-908.

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10.

Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function.

Tofaris GK, Razzaq A, Ghetti B, Lilley KS, Spillantini MG.

J Biol Chem. 2003 Nov 7;278(45):44405-11. Epub 2003 Aug 15.

11.

Degradation of alpha-synuclein by proteasome.

Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, Mouradian MM.

J Biol Chem. 1999 Nov 26;274(48):33855-8.

12.

Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro.

Lehmensiek V, Tan EM, Schwarz J, Storch A.

Neuroreport. 2002 Jul 19;13(10):1279-83.

PMID:
12151787
13.

Pyrrolidine dithiocarbamate and zinc inhibit proteasome-dependent proteolysis.

Kim I, Kim CH, Kim JH, Lee J, Choi JJ, Chen ZA, Lee MG, Chung KC, Hsu CY, Ahn YS.

Exp Cell Res. 2004 Aug 1;298(1):229-38.

PMID:
15242777
14.

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis.

Tanaka Y, Engelender S, Igarashi S, Rao RK, Wanner T, Tanzi RE, Sawa A, L Dawson V, Dawson TM, Ross CA.

Hum Mol Genet. 2001 Apr 15;10(9):919-26.

PMID:
11309365
15.

Dieldrin induces ubiquitin-proteasome dysfunction in alpha-synuclein overexpressing dopaminergic neuronal cells and enhances susceptibility to apoptotic cell death.

Sun F, Anantharam V, Latchoumycandane C, Kanthasamy A, Kanthasamy AG.

J Pharmacol Exp Ther. 2005 Oct;315(1):69-79. Epub 2005 Jun 29.

16.

Proteasomal inhibition hypersensitizes differentiated neuroblastoma cells to oxidative damage.

Lev N, Melamed E, Offen D.

Neurosci Lett. 2006 May 15;399(1-2):27-32. Epub 2006 Apr 11.

PMID:
16584840
17.

Induction of alpha-synuclein aggregation by intracellular nitrative insult.

Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, Ischiropoulos H.

J Neurosci. 2001 Oct 15;21(20):8053-61.

18.

Impairment of the ubiquitin-proteasome system causes dopaminergic cell death and inclusion body formation in ventral mesencephalic cultures.

McNaught KS, Mytilineou C, Jnobaptiste R, Yabut J, Shashidharan P, Jennert P, Olanow CW.

J Neurochem. 2002 Apr;81(2):301-6.

19.

alpha-synuclein is required for the fibrillar nature of ubiquitinated inclusions induced by proteasomal inhibition in primary neurons.

Rideout HJ, Dietrich P, Wang Q, Dauer WT, Stefanis L.

J Biol Chem. 2004 Nov 5;279(45):46915-20. Epub 2004 Aug 18.

20.

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