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Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.

Wilson FH, Kahle KT, Sabath E, Lalioti MD, Rapson AK, Hoover RS, Hebert SC, Gamba G, Lifton RP.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):680-4. Epub 2003 Jan 6.


WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.


Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.

Golbang AP, Cope G, Hamad A, Murthy M, Liu CH, Cuthbert AW, O'shaughnessy KM.

Am J Physiol Renal Physiol. 2006 Dec;291(6):F1369-76. Epub 2006 Jun 20.


WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.

Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP.

Nat Genet. 2003 Dec;35(4):372-6. Epub 2003 Nov 9.


WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC.

J Physiol. 2006 Mar 1;571(Pt 2):275-86. Epub 2005 Dec 15.


Increased urinary Na-Cl cotransporter protein in familial hyperkalaemia and hypertension.

Mayan H, Attar-Herzberg D, Shaharabany M, Holtzman EJ, Farfel Z.

Nephrol Dial Transplant. 2008 Feb;23(2):492-6. Epub 2007 Oct 19.


A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene.

Golbang AP, Murthy M, Hamad A, Liu CH, Cope G, Van't Hoff W, Cuthbert A, O'Shaughnessy KM.

Hypertension. 2005 Aug;46(2):295-300. Epub 2005 Jul 5.


WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.

San-Cristobal P, Ponce-Coria J, Vázquez N, Bobadilla NA, Gamba G.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1199-206. doi: 10.1152/ajprenal.90396.2008. Epub 2008 Aug 13.


The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.

Yang CL, Zhu X, Ellison DH.

J Clin Invest. 2007 Nov;117(11):3403-11.


WNK4 regulates activity of the epithelial Na+ channel in vitro and in vivo.

Ring AM, Cheng SX, Leng Q, Kahle KT, Rinehart J, Lalioti MD, Volkman HM, Wilson FH, Hebert SC, Lifton RP.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4020-4. Epub 2007 Feb 26.


WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J.

Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11.


Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.

San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4384-9. doi: 10.1073/pnas.0813238106. Epub 2009 Feb 24.


WNK4 kinase is a negative regulator of K+-Cl- cotransporters.

Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G.

Am J Physiol Renal Physiol. 2007 Apr;292(4):F1197-207. Epub 2006 Dec 19.


WNK4 regulates apical and basolateral Cl- flux in extrarenal epithelia.

Kahle KT, Gimenez I, Hassan H, Wilson FH, Wong RD, Forbush B, Aronson PS, Lifton RP.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2064-9. Epub 2004 Feb 9.


Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport.

Yang CL, Zhu X, Wang Z, Subramanya AR, Ellison DH.

J Clin Invest. 2005 May;115(5):1379-87. Epub 2005 Apr 7.


Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions.

Na T, Wu G, Peng JB.

Biochem Biophys Res Commun. 2012 Mar 9;419(2):293-8. doi: 10.1016/j.bbrc.2012.02.013. Epub 2012 Feb 11.


WNK kinases, renal ion transport and hypertension.

San-Cristobal P, de los Heros P, Ponce-Coria J, Moreno E, Gamba G.

Am J Nephrol. 2008;28(5):860-70. doi: 10.1159/000139639. Epub 2008 Jun 12. Review.


Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S.

Hum Mol Genet. 2014 Oct 1;23(19):5052-60. doi: 10.1093/hmg/ddu217. Epub 2014 May 12.


Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells.

Yang SS, Yamauchi K, Rai T, Hiyama A, Sohara E, Suzuki T, Itoh T, Suda S, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2005 May 6;330(2):410-4.


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