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Items: 1 to 20 of 250

1.

Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.

Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC.

Mol Cell Biol. 2003 Jan;23(2):655-64.

2.
3.

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.

J Neurochem. 2000 Aug;75(2):583-93.

4.

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.

J Biol Chem. 2004 Jul 16;279(29):30771-80. Epub 2004 May 3.

5.

Identification and characterization of presenilin-independent Notch signaling.

Berechid BE, Kitzmann M, Foltz DR, Roach AH, Seiffert D, Thompson LA, Olson RE, Bernstein A, Donoviel DB, Nye JS.

J Biol Chem. 2002 Mar 8;277(10):8154-65. Epub 2001 Dec 26.

6.

Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain.

Chu J, Jeffries S, Norton JE, Capobianco AJ, Bresnick EH.

J Biol Chem. 2002 Mar 1;277(9):7587-97. Epub 2001 Dec 5.

7.

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors.

Wu L, Sun T, Kobayashi K, Gao P, Griffin JD.

Mol Cell Biol. 2002 Nov;22(21):7688-700.

8.
9.

New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.

Hales EC, Taub JW, Matherly LH.

Cell Signal. 2014 Jan;26(1):149-61. doi: 10.1016/j.cellsig.2013.09.021. Epub 2013 Oct 16. Review.

PMID:
24140475
10.

Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.

Miyamoto A, Lau R, Hein PW, Shipley JM, Weinmaster G.

J Biol Chem. 2006 Apr 14;281(15):10089-97. Epub 2006 Feb 20.

11.

Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex.

Nam Y, Weng AP, Aster JC, Blacklow SC.

J Biol Chem. 2003 Jun 6;278(23):21232-9. Epub 2003 Mar 18.

12.
13.

Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines.

Dohda T, Maljukova A, Liu L, Heyman M, Grandér D, Brodin D, Sangfelt O, Lendahl U.

Exp Cell Res. 2007 Aug 15;313(14):3141-52. Epub 2007 May 5.

PMID:
17560996
14.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

15.

Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K/Akt pathways and requires MAML1.

Liu ZJ, Xiao M, Balint K, Soma A, Pinnix CC, Capobianco AJ, Velazquez OC, Herlyn M.

FASEB J. 2006 May;20(7):1009-11. Epub 2006 Mar 29.

PMID:
16571776
16.

Notch signaling in leukemia.

Aster JC, Pear WS.

Curr Opin Hematol. 2001 Jul;8(4):237-44.

PMID:
11561162
17.

Notch signaling augments T cell responsiveness by enhancing CD25 expression.

Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS.

J Immunol. 2003 Sep 15;171(6):2896-903.

18.
19.

Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis.

Saxena MT, Schroeter EH, Mumm JS, Kopan R.

J Biol Chem. 2001 Oct 26;276(43):40268-73. Epub 2001 Aug 22.

20.

Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3).

Murata K, Kumagai H, Kawashima T, Tamitsu K, Irie M, Nakajima H, Suzu S, Shibuya M, Kamihira S, Nosaka T, Asano S, Kitamura T.

J Biol Chem. 2003 Aug 29;278(35):32892-8. Epub 2003 Jun 18.

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