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The CD8alpha gene locus is regulated by the Ikaros family of proteins.

Harker N, Naito T, Cortes M, Hostert A, Hirschberg S, Tolaini M, Roderick K, Georgopoulos K, Kioussis D.

Mol Cell. 2002 Dec;10(6):1403-15.


Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development.

Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, Kioussis D.

J Immunol. 2011 Jun 1;186(11):6368-77. doi: 10.4049/jimmunol.1003567. Epub 2011 Apr 22.


Expression patterns of Ikaros family members during positive selection and lineage commitment of human thymocytes.

Mitchell JL, Seng A, Yankee TM.

Immunology. 2016 Dec;149(4):400-412. doi: 10.1111/imm.12657. Epub 2016 Sep 20.


Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator.

Trinh LA, Ferrini R, Cobb BS, Weinmann AS, Hahm K, Ernst P, Garraway IP, Merkenschlager M, Smale ST.

Genes Dev. 2001 Jul 15;15(14):1817-32.


The role of the Ikaros gene in lymphocyte development and homeostasis.

Georgopoulos K, Winandy S, Avitahl N.

Annu Rev Immunol. 1997;15:155-76. Review.


A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis.

Kaufmann C, Yoshida T, Perotti EA, Landhuis E, Wu P, Georgopoulos K.

EMBO J. 2003 May 1;22(9):2211-23.


Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells.

Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Fukuyama H, Wardemann H, Waldschuetz R, Möröy T, Taniuchi I, Steimle V, Littman DR, Ehlers M.

J Immunol. 2005 Aug 1;175(3):1694-705. Erratum in: J Immunol. 2005 Nov 1;175(9):6238.


Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation.

Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K.

EMBO J. 1997 Apr 15;16(8):2004-13.


Dual functions of Runx proteins for reactivating CD8 and silencing CD4 at the commitment process into CD8 thymocytes.

Sato T, Ohno S, Hayashi T, Sato C, Kohu K, Satake M, Habu S.

Immunity. 2005 Mar;22(3):317-28.


A CD8/Lck transgene is able to drive thymocyte differentiation.

Fragoso RC, Pyarajan S, Irie HY, Burakoff SJ.

J Immunol. 2006 Nov 1;177(9):6007-17.


Variegated expression of CD8 alpha resulting from in situ deletion of regulatory sequences.

Garefalaki A, Coles M, Hirschberg S, Mavria G, Norton T, Hostert A, Kioussis D.

Immunity. 2002 May;16(5):635-47.


The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse.

Molnár A, Wu P, Largespada DA, Vortkamp A, Scherer S, Copeland NG, Jenkins NA, Bruns G, Georgopoulos K.

J Immunol. 1996 Jan 15;156(2):585-92.


A region in the CD8 gene locus that directs expression to the mature CD8 T cell subset in transgenic mice.

Hostert A, Tolaini M, Roderick K, Harker N, Norton T, Kioussis D.

Immunity. 1997 Oct;7(4):525-36.


Helios deficiency has minimal impact on T cell development and function.

Cai Q, Dierich A, Oulad-Abdelghani M, Chan S, Kastner P.

J Immunol. 2009 Aug 15;183(4):2303-11. doi: 10.4049/jimmunol.0901407. Epub 2009 Jul 20.


Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin.

Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AG.

Cell. 1997 Dec 12;91(6):845-54.

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