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Items: 1 to 20 of 112


Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling.

Rosenberger G, Jantke I, Gal A, Kutsche K.

Hum Mol Genet. 2003 Jan 15;12(2):155-67.


The first CH domain of affixin activates Cdc42 and Rac1 through alphaPIX, a Cdc42/Rac1-specific guanine nucleotide exchanging factor.

Mishima W, Suzuki A, Yamaji S, Yoshimi R, Ueda A, Kaneko T, Tanaka J, Miwa Y, Ohno S, Ishigatsubo Y.

Genes Cells. 2004 Mar;9(3):193-204.


AlphaPIX associates with calpain 4, the small subunit of calpain, and has a dual role in integrin-mediated cell spreading.

Rosenberger G, Gal A, Kutsche K.

J Biol Chem. 2005 Feb 25;280(8):6879-89. Epub 2004 Dec 20.


Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation.

Kutsche K, Yntema H, Brandt A, Jantke I, Nothwang HG, Orth U, Boavida MG, David D, Chelly J, Fryns JP, Moraine C, Ropers HH, Hamel BC, van Bokhoven H, Gal A.

Nat Genet. 2000 Oct;26(2):247-50.


The gamma-parvin-integrin-linked kinase complex is critically involved in leukocyte-substrate interaction.

Yoshimi R, Yamaji S, Suzuki A, Mishima W, Okamura M, Obana T, Matsuda C, Miwa Y, Ohno S, Ishigatsubo Y.

J Immunol. 2006 Mar 15;176(6):3611-24.


Affixin activates Rac1 via betaPIX in C2C12 myoblast.

Matsuda C, Kameyama K, Suzuki A, Mishima W, Yamaji S, Okamoto H, Nishino I, Hayashi YK.

FEBS Lett. 2008 Apr 9;582(8):1189-96. doi: 10.1016/j.febslet.2008.01.064. Epub 2008 Mar 4.


alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase.

Yoshii S, Tanaka M, Otsuki Y, Wang DY, Guo RJ, Zhu Y, Takeda R, Hanai H, Kaneko E, Sugimura H.

Oncogene. 1999 Oct 7;18(41):5680-90.


Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.

Ramakers GJ, Wolfer D, Rosenberger G, Kuchenbecker K, Kreienkamp HJ, Prange-Kiel J, Rune G, Richter K, Langnaese K, Masneuf S, Bösl MR, Fischer KD, Krugers HJ, Lipp HP, van Galen E, Kutsche K.

Hum Mol Genet. 2012 Jan 15;21(2):268-86. doi: 10.1093/hmg/ddr457. Epub 2011 Oct 11.


AlphaPIX and betaPIX and their role in focal adhesion formation.

Rosenberger G, Kutsche K.

Eur J Cell Biol. 2006 Apr;85(3-4):265-74. Epub 2005 Dec 5. Review.


Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction.

Yamaji S, Suzuki A, Kanamori H, Mishima W, Yoshimi R, Takasaki H, Takabayashi M, Fujimaki K, Fujisawa S, Ohno S, Ishigatsubo Y.

J Cell Biol. 2004 May 24;165(4):539-51.


The integrin cytoplasmic domain-associated protein ICAP-1 binds and regulates Rho family GTPases during cell spreading.

Degani S, Balzac F, Brancaccio M, Guazzone S, Retta SF, Silengo L, Eva A, Tarone G.

J Cell Biol. 2002 Jan 21;156(2):377-87. Epub 2002 Jan 21.


A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction.

Yamaji S, Suzuki A, Sugiyama Y, Koide Y, Yoshida M, Kanamori H, Mohri H, Ohno S, Ishigatsubo Y.

J Cell Biol. 2001 Jun 11;153(6):1251-64.


Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.


Hic-5 interacts with GIT1 with a different binding mode from paxillin.

Nishiya N, Shirai T, Suzuki W, Nose K.

J Biochem. 2002 Aug;132(2):279-89.


Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX.

Filipenko NR, Attwell S, Roskelley C, Dedhar S.

Oncogene. 2005 Sep 1;24(38):5837-49.


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