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Items: 1 to 20 of 110

1.

Improvement of "hit-to-lead" optimization by integration of in vitro HTS experimental models for early determination of pharmacokinetic properties.

Kariv I, Rourick RA, Kassel DB, Chung TD.

Comb Chem High Throughput Screen. 2002 Sep;5(6):459-72. Review.

PMID:
12470275
2.

Preclinical pharmacokinetics: an approach towards safer and efficacious drugs.

Singh SS.

Curr Drug Metab. 2006 Feb;7(2):165-82. Review.

PMID:
16472106
3.

Assessing the absorption of new pharmaceuticals.

Hidalgo IJ.

Curr Top Med Chem. 2001 Nov;1(5):385-401. Review.

PMID:
11899104
4.

In vitro high throughput screening of compounds for favorable metabolic properties in drug discovery.

Masimirembwa CM, Thompson R, Andersson TB.

Comb Chem High Throughput Screen. 2001 May;4(3):245-63. Review.

PMID:
11375740
5.

Introduction to in vitro estimation of metabolic stability and drug interactions of new chemical entities in drug discovery and development.

Baranczewski P, Stańczak A, Sundberg K, Svensson R, Wallin A, Jansson J, Garberg P, Postlind H.

Pharmacol Rep. 2006 Jul-Aug;58(4):453-72. Review.

6.

High throughput screening of physicochemical properties and in vitro ADME profiling in drug discovery.

Wan H, Holmén AG.

Comb Chem High Throughput Screen. 2009 Mar;12(3):315-29.

PMID:
19275537
7.

Recent development in high-throughput bioanalytical support for in vitro ADMET profiling.

Shou WZ, Zhang J.

Expert Opin Drug Metab Toxicol. 2010 Mar;6(3):321-36. doi: 10.1517/17425250903547829. Review.

PMID:
20163321
8.
9.

[High throughput screening of pharmacokinetics and metabolism in drug discovery (II)--investigation on in vitro and in vivo correlation in drug metabolism screening].

Komura H, Matsuda K, Shigemoto Y, Kawahara I, Ano R, Murayama Y, Moriwaki T, Yoshida NH.

Yakugaku Zasshi. 2005 Jan;125(1):131-9. Japanese.

11.
12.

Solubility and permeability measurement and applications in drug discovery.

Burton PS, Goodwin JT.

Comb Chem High Throughput Screen. 2010 Feb;13(2):101-11. Review.

PMID:
20053165
13.

[High throughput screening of pharmacokinetics and metabolism in drug discovery (III)--investigation on in- silico model for membrane permeability and CYP1A2 inhibition].

Komura H, Shigemoto Y, Kawahara I, Matsuda K, Ano R, Murayama Y, Moriwaki T, Yoshida NH.

Yakugaku Zasshi. 2005 Jan;125(1):141-7. Japanese.

14.

Novel trends in high-throughput screening.

Mayr LM, Bojanic D.

Curr Opin Pharmacol. 2009 Oct;9(5):580-8. doi: 10.1016/j.coph.2009.08.004. Epub 2009 Sep 21. Review.

PMID:
19775937
15.

Automatic mass spectrometry method development for drug discovery: application in metabolic stability assays.

Chovan LE, Black-Schaefer C, Dandliker PJ, Lau YY.

Rapid Commun Mass Spectrom. 2004;18(24):3105-12.

PMID:
15565734
16.

Applications of high throughput microsomal stability assay in drug discovery.

Di L, Kerns EH, Ma XJ, Huang Y, Carter GT.

Comb Chem High Throughput Screen. 2008 Jul;11(6):469-76.

PMID:
18673274
17.

Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery.

Yan Z, Caldwell GW.

Curr Top Med Chem. 2001 Nov;1(5):403-25. Review.

PMID:
11899105
18.

In vitro ADME profiling using high-throughput rapidfire mass spectrometry: cytochrome p450 inhibition and metabolic stability assays.

Wu X, Wang J, Tan L, Bui J, Gjerstad E, McMillan K, Zhang W.

J Biomol Screen. 2012 Jul;17(6):761-72. doi: 10.1177/1087057112441013. Epub 2012 Mar 29.

PMID:
22460176
20.

Mass spectrometric techniques for label-free high-throughput screening in drug discovery.

Roddy TP, Horvath CR, Stout SJ, Kenney KL, Ho PI, Zhang JH, Vickers C, Kaushik V, Hubbard B, Wang YK.

Anal Chem. 2007 Nov 1;79(21):8207-13. Epub 2007 Sep 29.

PMID:
17902631

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