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Items: 1 to 20 of 217

1.

Acid Denaturation of alpha1-antitrypsin: characterization of a novel mechanism of serpin polymerization.

Devlin GL, Chow MK, Howlett GJ, Bottomley SP.

J Mol Biol. 2002 Dec 6;324(4):859-70.

PMID:
12460583
2.

A kinetic mechanism for the polymerization of alpha1-antitrypsin.

Dafforn TR, Mahadeva R, Elliott PR, Sivasothy P, Lomas DA.

J Biol Chem. 1999 Apr 2;274(14):9548-55.

4.

The mechanism of alpha 1-antitrypsin polymerization probed by fluorescence spectroscopy.

James EL, Bottomley SP.

Arch Biochem Biophys. 1998 Aug 15;356(2):296-300.

PMID:
9705220
5.
6.

Loop-sheet polymerization: the mechanism of alpha1-antitrypsin deficiency.

Lomas DA.

Respir Med. 2000 Aug;94 Suppl C:S3-6.

PMID:
10954247
7.

Probing the role of the F-helix in serpin stability through a single tryptophan substitution.

Cabrita LD, Whisstock JC, Bottomley SP.

Biochemistry. 2002 Apr 9;41(14):4575-81.

PMID:
11926819
8.

Preparative induction and characterization of L-antithrombin: a structural homologue of latent plasminogen activator inhibitor-1.

Wardell MR, Chang WS, Bruce D, Skinner R, Lesk AM, Carrell RW.

Biochemistry. 1997 Oct 21;36(42):13133-42.

PMID:
9335576
9.

Kinetic instability of the serpin Z alpha1-antitrypsin promotes aggregation.

Knaupp AS, Levina V, Robertson AL, Pearce MC, Bottomley SP.

J Mol Biol. 2010 Feb 19;396(2):375-83. doi: 10.1016/j.jmb.2009.11.048. Epub 2009 Nov 26.

PMID:
19944704
10.
11.

The human serpin proteinase inhibitor-9 self-associates at physiological temperatures.

Benning LN, Whisstock JC, Sun J, Bird PI, Bottomley SP.

Protein Sci. 2004 Jul;13(7):1859-64.

12.

Role of the connectivity of secondary structure segments in the folding of alpha(1)-antitrypsin.

Lee C, Seo EJ, Yu MH.

Biochem Biophys Res Commun. 2001 Sep 28;287(3):636-41.

PMID:
11563842
13.

Characterization of a human alpha1-antitrypsin variant that is as stable as ovalbumin.

Lee KN, Im H, Kang SW, Yu MH.

J Biol Chem. 1998 Jan 30;273(5):2509-16.

14.
15.

In vitro and in silico design of alpha1-antitrypsin mutants with different conformational stabilities.

Gilis D, McLennan HR, Dehouck Y, Cabrita LD, Rooman M, Bottomley SP.

J Mol Biol. 2003 Jan 17;325(3):581-9.

PMID:
12498804
16.

Bypassing the kinetic trap of serpin protein folding by loop extension.

Im H, Ahn HY, Yu MH.

Protein Sci. 2000 Aug;9(8):1497-502.

17.

Probing the local conformational change of alpha1-antitrypsin.

Baek JH, Im H, Kang UB, Seong KM, Lee C, Kim J, Yu MH.

Protein Sci. 2007 Sep;16(9):1842-50. Epub 2007 Jul 27.

19.

Osmolytes as modulators of conformational changes in serpins.

Chow MK, Devlin GL, Bottomley SP.

Biol Chem. 2001 Nov;382(11):1593-9.

PMID:
11767949
20.

alpha 1-Antitrypsin Mmalton (Phe52-deleted) forms loop-sheet polymers in vivo. Evidence for the C sheet mechanism of polymerization.

Lomas DA, Elliott PR, Sidhar SK, Foreman RC, Finch JT, Cox DW, Whisstock JC, Carrell RW.

J Biol Chem. 1995 Jul 14;270(28):16864-70.

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