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Items: 1 to 20 of 199

2.
3.
4.

Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies.

Desta Z, Soukhova N, Mahal SK, Flockhart DA.

Drug Metab Dispos. 2000 Jul;28(7):789-800.

5.

Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.

Marill J, Cresteil T, Lanotte M, Chabot GG.

Mol Pharmacol. 2000 Dec;58(6):1341-8.

6.
7.

In vitro human metabolism and interactions of repellent N,N-diethyl-m-toluamide.

Usmani KA, Rose RL, Goldstein JA, Taylor WG, Brimfield AA, Hodgson E.

Drug Metab Dispos. 2002 Mar;30(3):289-94.

8.

Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.

Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS.

Drug Metab Dispos. 2008 Aug;36(8):1637-49. doi: 10.1124/dmd.107.019562. Epub 2008 May 7.

9.

O-demethylation of epipodophyllotoxins is catalyzed by human cytochrome P450 3A4.

Relling MV, Nemec J, Schuetz EG, Schuetz JD, Gonzalez FJ, Korzekwa KR.

Mol Pharmacol. 1994 Feb;45(2):352-8. Erratum in: Mol Pharmacol 1995 Sep;48(3):568.

PMID:
8114683
10.

Identification of cytochrome P450 forms involved in the 4-hydroxylation of valsartan, a potent and specific angiotensin II receptor antagonist, in human liver microsomes.

Nakashima A, Kawashita H, Masuda N, Saxer C, Niina M, Nagae Y, Iwasaki K.

Xenobiotica. 2005 Jun;35(6):589-602.

PMID:
16192110
11.

In vitro metabolism of chloroquine: identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formation.

Projean D, Baune B, Farinotti R, Flinois JP, Beaune P, Taburet AM, Ducharme J.

Drug Metab Dispos. 2003 Jun;31(6):748-54.

12.

Evidence for the involvement of human liver microsomes CYP1A2 in the mono-hydroxylation of daidzein.

Peng WX, Wang LS, Li HD, Abd El-Aty AM, Chen GL, Zhou HH.

Clin Chim Acta. 2003 Aug;334(1-2):77-85.

PMID:
12867277
13.

Both cytochromes P450 2E1 and 3A are involved in the O-hydroxylation of p-nitrophenol, a catalytic activity known to be specific for P450 2E1.

Zerilli A, Ratanasavanh D, Lucas D, Goasduff T, Dréano Y, Menard C, Picart D, Berthou F.

Chem Res Toxicol. 1997 Oct;10(10):1205-12.

PMID:
9348445
14.

Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028.

Kim H, Yoon YJ, Kim H, Kang S, Cheon HG, Yoo SE, Shin JG, Liu KH.

Toxicol Lett. 2006 Oct 10;166(2):105-14. Epub 2006 Jun 12.

PMID:
16857327
15.
16.

Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450.

Ueng YF, Don MJ, Jan WC, Wang SY, Ho LK, Chen CF.

Drug Metab Dispos. 2006 May;34(5):821-7. Epub 2006 Feb 24.

17.

Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A.

Desta Z, Soukhova N, Morocho AM, Flockhart DA.

J Pharmacol Exp Ther. 2001 Aug;298(2):508-20.

18.

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes.

Wormhoudt LW, Ploemen JH, de Waziers I, Commandeur JN, Beaune PH, van Bladeren PJ, Vermeulen NP.

Chem Biol Interact. 1996 Sep 6;101(3):175-92.

PMID:
8870687
19.

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate.

Li XQ, Björkman A, Andersson TB, Ridderström M, Masimirembwa CM.

J Pharmacol Exp Ther. 2002 Feb;300(2):399-407.

20.

Cytochrome P450 3A4 is the major enzyme involved in the metabolism of the substance P receptor antagonist aprepitant.

Sanchez RI, Wang RW, Newton DJ, Bakhtiar R, Lu P, Chiu SH, Evans DC, Huskey SE.

Drug Metab Dispos. 2004 Nov;32(11):1287-92. Epub 2004 Aug 10.

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