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Items: 1 to 20 of 63

1.

mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.

Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.

Cell. 2002 Jul 26;110(2):163-75.

PMID:
12150925
2.

Raptor and mTOR: subunits of a nutrient-sensitive complex.

Kim DH, Sabatini DM.

Curr Top Microbiol Immunol. 2004;279:259-70. Review.

PMID:
14560962
3.

Raptor, a binding partner of target of rapamycin.

Yonezawa K, Tokunaga C, Oshiro N, Yoshino K.

Biochem Biophys Res Commun. 2004 Jan 9;313(2):437-41. Review.

PMID:
14684181
4.

GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR.

Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, Tempst P, Sabatini DM.

Mol Cell. 2003 Apr;11(4):895-904.

5.

Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.

Sarbassov DD, Sabatini DM.

J Biol Chem. 2005 Nov 25;280(47):39505-9. Epub 2005 Sep 23.

6.

Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.

Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K.

Cell. 2002 Jul 26;110(2):177-89.

PMID:
12150926
7.

Phosphatidic acid-mediated mitogenic activation of mTOR signaling.

Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J.

Science. 2001 Nov 30;294(5548):1942-5.

8.

Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.

Oshiro N, Yoshino K, Hidayat S, Tokunaga C, Hara K, Eguchi S, Avruch J, Yonezawa K.

Genes Cells. 2004 Apr;9(4):359-66. Erratum in: Genes Cells. 2004 May;9(5):497.

9.

The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.

Nojima H, Tokunaga C, Eguchi S, Oshiro N, Hidayat S, Yoshino K, Hara K, Tanaka N, Avruch J, Yonezawa K.

J Biol Chem. 2003 May 2;278(18):15461-4. Epub 2003 Feb 25.

10.

The mammalian target of rapamycin regulates C2C12 myogenesis via a kinase-independent mechanism.

Erbay E, Chen J.

J Biol Chem. 2001 Sep 28;276(39):36079-82. Epub 2001 Aug 10.

11.
12.

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.

Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM.

Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1432-7.

13.

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways.

Liu L, Li F, Cardelli JA, Martin KA, Blenis J, Huang S.

Oncogene. 2006 Nov 9;25(53):7029-40. Epub 2006 May 22.

PMID:
16715128
14.

A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.

Bachmann RA, Kim JH, Wu AL, Park IH, Chen J.

J Biol Chem. 2006 Mar 17;281(11):7357-63. Epub 2006 Jan 9.

15.

Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling.

Sabatini DM, Barrow RK, Blackshaw S, Burnett PE, Lai MM, Field ME, Bahr BA, Kirsch J, Betz H, Snyder SH.

Science. 1999 May 14;284(5417):1161-4.

16.

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin.

Ohji G, Hidayat S, Nakashima A, Tokunaga C, Oshiro N, Yoshino K, Yokono K, Kikkawa U, Yonezawa K.

J Biochem. 2006 Jan;139(1):129-35.

PMID:
16428328
17.

Rheb activation of mTOR and S6K1 signaling.

Hanrahan J, Blenis J.

Methods Enzymol. 2006;407:542-55.

PMID:
16757352
18.

Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site.

Ali SM, Sabatini DM.

J Biol Chem. 2005 May 20;280(20):19445-8. Epub 2005 Apr 4.

19.

Expression of mTOR pathway proteins in human amniotic fluid stem cells.

Siegel N, Valli A, Fuchs C, Rosner M, Hengstschläger M.

Int J Mol Med. 2009 Jun;23(6):779-84.

PMID:
19424604
20.

The molecular target of rapamycin (mTOR) as a therapeutic target against cancer.

Mita MM, Mita A, Rowinsky EK.

Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S169-77. Review.

PMID:
14508096

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