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Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

Hagting A, Den Elzen N, Vodermaier HC, Waizenegger IC, Peters JM, Pines J.

J Cell Biol. 2002 Jun 24;157(7):1125-37. Epub 2002 Jun 17.


Cdc20 and Cks direct the spindle checkpoint-independent destruction of cyclin A.

Wolthuis R, Clay-Farrace L, van Zon W, Yekezare M, Koop L, Ogink J, Medema R, Pines J.

Mol Cell. 2008 May 9;30(3):290-302. doi: 10.1016/j.molcel.2008.02.027.


Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage.

Tinker-Kulberg RL, Morgan DO.

Genes Dev. 1999 Aug 1;13(15):1936-49.


The APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exit.

van Zon W, Ogink J, ter Riet B, Medema RH, te Riele H, Wolthuis RM.

J Cell Biol. 2010 Aug 23;190(4):587-602. doi: 10.1083/jcb.200912084.


Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.

Homer HA, McDougall A, Levasseur M, Murdoch AP, Herbert M.

Reproduction. 2005 Dec;130(6):829-43.


How APC/C-Cdc20 changes its substrate specificity in mitosis.

Izawa D, Pines J.

Nat Cell Biol. 2011 Mar;13(3):223-33. doi: 10.1038/ncb2165. Epub 2011 Feb 20. Erratum in: Nat Cell Biol. 2011 May;13(5):633.


Inefficient degradation of cyclin B1 re-activates the spindle checkpoint right after sister chromatid disjunction.

Clijsters L, van Zon W, Riet BT, Voets E, Boekhout M, Ogink J, Rumpf-Kienzl C, Wolthuis RM.

Cell Cycle. 2014;13(15):2370-8. doi: 10.4161/cc.29336.


Dual inhibition of sister chromatid separation at metaphase.

Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW.

Cell. 2001 Dec 14;107(6):715-26.


Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase.

Vázquez-Novelle MD, Sansregret L, Dick AE, Smith CA, McAinsh AD, Gerlich DW, Petronczki M.

Curr Biol. 2014 Mar 17;24(6):638-45. doi: 10.1016/j.cub.2014.01.034. Epub 2014 Feb 27.


Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.

Jeganathan KB, Baker DJ, van Deursen JM.

Cell Cycle. 2006 Feb;5(4):366-70. Epub 2006 Feb 15.


Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction.

Holland AJ, Taylor SS.

J Cell Sci. 2006 Aug 15;119(Pt 16):3325-36. Epub 2006 Jul 25.


Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint.

van Zon W, Wolthuis RM.

Biochem Soc Trans. 2010 Feb;38(Pt 1):72-7. doi: 10.1042/BST0380072. Review.


The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation.

Jeganathan KB, Malureanu L, van Deursen JM.

Nature. 2005 Dec 15;438(7070):1036-9.


Human T-lymphotropic virus type 1 oncoprotein tax promotes unscheduled degradation of Pds1p/securin and Clb2p/cyclin B1 and causes chromosomal instability.

Liu B, Liang MH, Kuo YL, Liao W, Boros I, Kleinberger T, Blancato J, Giam CZ.

Mol Cell Biol. 2003 Aug;23(15):5269-81.


Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.

Tian W, Li B, Warrington R, Tomchick DR, Yu H, Luo X.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18419-24. doi: 10.1073/pnas.1213438109. Epub 2012 Oct 22.


Degradation of APCcdc20 and APCcdh1 substrates during the second meiotic division in mouse eggs.

Chang HY, Levasseur M, Jones KT.

J Cell Sci. 2004 Dec 15;117(Pt 26):6289-96. Epub 2004 Nov 23.

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