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Items: 1 to 20 of 119

1.

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

Humbert S, Bryson EA, Cordelières FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F.

Dev Cell. 2002 Jun;2(6):831-7.

2.

Phosphorylation of arfaptin 2 at Ser260 by Akt Inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment.

Rangone H, Pardo R, Colin E, Girault JA, Saudou F, Humbert S.

J Biol Chem. 2005 Jun 10;280(23):22021-8. Epub 2005 Apr 4.

3.

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin.

Rangone H, Poizat G, Troncoso J, Ross CA, MacDonald ME, Saudou F, Humbert S.

Eur J Neurosci. 2004 Jan;19(2):273-9.

PMID:
14725621
4.

Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis.

Miller J, Arrasate M, Shaby BA, Mitra S, Masliah E, Finkbeiner S.

J Neurosci. 2010 Aug 4;30(31):10541-50. doi: 10.1523/JNEUROSCI.0146-10.2010.

5.

[Huntington's disease: intracellular signaling pathways and neuronal death].

Humbert S, Saudou F.

J Soc Biol. 2005;199(3):247-51. Review. French.

PMID:
16471265
6.
7.

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death.

Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S.

Nature. 2004 Oct 14;431(7010):805-10.

8.

Akt is altered in an animal model of Huntington's disease and in patients.

Colin E, Régulier E, Perrin V, Dürr A, Brice A, Aebischer P, Déglon N, Humbert S, Saudou F.

Eur J Neurosci. 2005 Mar;21(6):1478-88.

PMID:
15845076
9.

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421.

Pardo R, Colin E, Régulier E, Aebischer P, Déglon N, Humbert S, Saudou F.

J Neurosci. 2006 Feb 1;26(5):1635-45.

10.

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington's disease knock-in striatal cells.

Ribeiro M, Rosenstock TR, Oliveira AM, Oliveira CR, Rego AC.

Free Radic Biol Med. 2014 Sep;74:129-44. doi: 10.1016/j.freeradbiomed.2014.06.023. Epub 2014 Jun 30.

PMID:
24992836
11.

Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells.

Gines S, Ivanova E, Seong IS, Saura CA, MacDonald ME.

J Biol Chem. 2003 Dec 12;278(50):50514-22. Epub 2003 Oct 1.

12.

Increased expression of Bim contributes to the potentiation of serum deprivation-induced apoptotic cell death in Huntington's disease knock-in striatal cell line.

Kong PJ, Kil MO, Lee H, Kim SS, Johnson GV, Chun W.

Neurol Res. 2009 Feb;31(1):77-83. doi: 10.1179/174313208X331572. Epub 2008 Aug 7.

PMID:
18691453
13.

Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease.

Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.

J Neurosci Res. 2010 Jan;88(1):179-90. doi: 10.1002/jnr.22184.

PMID:
19642201
14.

Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro.

Ermak G, Hench KJ, Chang KT, Sachdev S, Davies KJ.

J Biol Chem. 2009 May 1;284(18):11845-53. doi: 10.1074/jbc.M900639200. Epub 2009 Mar 6.

16.

Adenovirus vector-based in vitro neuronal cell model for Huntington's disease with human disease-like differential aggregation and degeneration.

Dong X, Zong S, Witting A, Lindenberg KS, Kochanek S, Huang B.

J Gene Med. 2012 Jul;14(7):468-81. doi: 10.1002/jgm.2641.

PMID:
22700462
17.

Impaired basal and running-induced hippocampal neurogenesis coincides with reduced Akt signaling in adult R6/1 HD mice.

Ransome MI, Hannan AJ.

Mol Cell Neurosci. 2013 May;54:93-107. doi: 10.1016/j.mcn.2013.01.005. Epub 2013 Feb 4.

PMID:
23384443
19.

Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment.

Zala D, Benchoua A, Brouillet E, Perrin V, Gaillard MC, Zurn AD, Aebischer P, Déglon N.

Neurobiol Dis. 2005 Dec;20(3):785-98. Epub 2005 Jul 11.

PMID:
16006135
20.

Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease.

Doria JG, Silva FR, de Souza JM, Vieira LB, Carvalho TG, Reis HJ, Pereira GS, Dobransky T, Ribeiro FM.

Br J Pharmacol. 2013 Jun;169(4):909-21. doi: 10.1111/bph.12164.

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