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Items: 1 to 20 of 223

1.

Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens.

Jarvest RL, Berge JM, Berry V, Boyd HF, Brown MJ, Elder JS, Forrest AK, Fosberry AP, Gentry DR, Hibbs MJ, Jaworski DD, O'Hanlon PJ, Pope AJ, Rittenhouse S, Sheppard RJ, Slater-Radosti C, Worby A.

J Med Chem. 2002 May 9;45(10):1959-62.

PMID:
11985462
2.

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown MJ, Brown P, Elder JS, Forrest AK, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Rittenhouse S, Sheppard RJ.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):665-8.

PMID:
12639554
3.

Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors.

Farhanullah, Kim SY, Yoon EJ, Choi EC, Kim S, Kang T, Samrin F, Puri S, Lee J.

Bioorg Med Chem. 2006 Nov 1;14(21):7154-9. Epub 2006 Jul 18.

PMID:
16854585
4.

2-[2-Substituted-3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-4-ones as Staphylococcus aureus methionyl-tRNA synthetase inhibitors.

Farhanullah, Kang T, Yoon EJ, Choi EC, Kim S, Lee J.

Eur J Med Chem. 2009 Jan;44(1):239-50. doi: 10.1016/j.ejmech.2008.02.021. Epub 2008 Mar 6.

PMID:
18403059
5.

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

Jarvest RL, Berge JM, Brown P, Houge-Frydrych CS, O'Hanlon PJ, McNair DJ, Pope AJ, Rittenhouse S.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1265-8.

PMID:
12657260
6.

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

Jarvest RL, Armstrong SA, Berge JM, Brown P, Elder JS, Brown MJ, Copley RC, Forrest AK, Hamprecht DW, O'Hanlon PJ, Mitchell DJ, Rittenhouse S, Witty DR.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3937-41.

PMID:
15225702
7.

Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold.

Tandon M, Coffen DL, Gallant P, Keith D, Ashwell MA.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1909-11.

PMID:
15050625
8.

Discovery of a potent and selective series of pyrazole bacterial methionyl-tRNA synthetase inhibitors.

Finn J, Mattia K, Morytko M, Ram S, Yang Y, Wu X, Mak E, Gallant P, Keith D.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2231-4.

PMID:
12798340
9.

Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.

Seefeld MA, Miller WH, Newlander KA, Burgess WJ, DeWolf WE Jr, Elkins PA, Head MS, Jakas DR, Janson CA, Keller PM, Manley PJ, Moore TD, Payne DJ, Pearson S, Polizzi BJ, Qiu X, Rittenhouse SF, Uzinskas IN, Wallis NG, Huffman WF.

J Med Chem. 2003 Apr 24;46(9):1627-35.

PMID:
12699381
10.

Identification of novel inhibitors of methionyl-tRNA synthetase (MetRS) by virtual screening.

Finn J, Stidham M, Hilgers M, G C K.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3932-7. doi: 10.1016/j.bmcl.2008.06.032. Epub 2008 Jun 13.

PMID:
18590962
11.

Discovery and optimisation of potent, selective, ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase.

Jarvest RL, Erskine SG, Forrest AK, Fosberry AP, Hibbs MJ, Jones JJ, O'Hanlon PJ, Sheppard RJ, Worby A.

Bioorg Med Chem Lett. 2005 May 2;15(9):2305-9.

PMID:
15837314
12.

Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839.

Critchley IA, Ochsner UA.

Curr Opin Chem Biol. 2008 Aug;12(4):409-17. doi: 10.1016/j.cbpa.2008.06.011. Epub 2008 Jul 11. Review.

PMID:
18620074
13.

3-D-QSAR study and molecular docking of methionyl-tRNA synthetase inhibitors.

Kim SY, Lee J.

Bioorg Med Chem. 2003 Dec 1;11(24):5325-31.

PMID:
14642576
14.

Tyrosyl-tRNA synthetase inhibitors as antibacterial agents: synthesis, molecular docking and structure-activity relationship analysis of 3-aryl-4-arylaminofuran-2(5H)-ones.

Xiao ZP, Ma TW, Liao ML, Feng YT, Peng XC, Li JL, Li ZP, Wu Y, Luo Q, Deng Y, Liang X, Zhu HL.

Eur J Med Chem. 2011 Oct;46(10):4904-14. doi: 10.1016/j.ejmech.2011.07.047. Epub 2011 Aug 4.

PMID:
21856050
15.
16.

Preparation, antibacterial evaluation and preliminary structure-activity relationship (SAR) study of benzothiazol- and benzoxazol-2-amine derivatives.

Ouyang L, Huang Y, Zhao Y, He G, Xie Y, Liu J, He J, Liu B, Wei Y.

Bioorg Med Chem Lett. 2012 May 1;22(9):3044-9. doi: 10.1016/j.bmcl.2012.03.079. Epub 2012 Mar 28.

PMID:
22494615
17.

Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors.

Bharatham N, Bharatham K, Lee KW.

J Mol Graph Model. 2007 Mar;25(6):813-23. Epub 2006 Aug 14.

PMID:
16996282
18.

Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI).

Miller WH, Seefeld MA, Newlander KA, Uzinskas IN, Burgess WJ, Heerding DA, Yuan CC, Head MS, Payne DJ, Rittenhouse SF, Moore TD, Pearson SC, Berry V, DeWolf WE Jr, Keller PM, Polizzi BJ, Qiu X, Janson CA, Huffman WF.

J Med Chem. 2002 Jul 18;45(15):3246-56.

PMID:
12109908
19.

Synthesis and antibacterial evaluation of certain quinolone derivatives.

Chen YL, Fang KC, Sheu JY, Hsu SL, Tzeng CC.

J Med Chem. 2001 Jul 5;44(14):2374-7.

PMID:
11428933
20.

Identification of inhibitors of bacterial enoyl-acyl carrier protein reductase.

Moir DT.

Curr Drug Targets Infect Disord. 2005 Sep;5(3):297-305. Review.

PMID:
16181147

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