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Items: 1 to 20 of 150

1.

The PYRIN-CARD protein ASC is an activating adaptor for caspase-1.

Srinivasula SM, Poyet JL, Razmara M, Datta P, Zhang Z, Alnemri ES.

J Biol Chem. 2002 Jun 14;277(24):21119-22. Epub 2002 Apr 19.

2.

Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation.

Stehlik C, Lee SH, Dorfleutner A, Stassinopoulos A, Sagara J, Reed JC.

J Immunol. 2003 Dec 1;171(11):6154-63.

3.

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T, Alnemri ES.

Cell Death Differ. 2006 Feb;13(2):236-49.

4.

The CARD plays a critical role in ASC foci formation and inflammasome signalling.

Proell M, Gerlic M, Mace PD, Reed JC, Riedl SJ.

Biochem J. 2013 Feb 1;449(3):613-21. doi: 10.1042/BJ20121198.

5.

Purification and analysis of the interactions of caspase-1 and ASC for assembly of the inflammasome.

Narayanan KB, Park HH.

Appl Biochem Biotechnol. 2015 Mar;175(6):2883-94. doi: 10.1007/s12010-014-1471-4. Epub 2015 Jan 8.

PMID:
25567507
6.

Self-oligomerization of ASC PYD domain prevents the assembly of inflammasome in vitro.

Narayanan KB, Jang TH, Park HH.

Appl Biochem Biotechnol. 2014 Apr;172(8):3902-12. doi: 10.1007/s12010-014-0819-0. Epub 2014 Mar 2.

PMID:
24585381
7.

Mapping of POP1-binding site on pyrin domain of ASC.

Srimathi T, Robbins SL, Dubas RL, Chang H, Cheng H, Roder H, Park YC.

J Biol Chem. 2008 May 30;283(22):15390-8. doi: 10.1074/jbc.M801589200. Epub 2008 Mar 24.

8.

ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis.

Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Taniguchi S, Gumucio DL, Núñez G, Inohara N.

Biochem Biophys Res Commun. 2003 Mar 28;303(1):69-73.

PMID:
12646168
9.

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

Papin S, Cuenin S, Agostini L, Martinon F, Werner S, Beer HD, Grütter C, Grütter M, Tschopp J.

Cell Death Differ. 2007 Aug;14(8):1457-66. Epub 2007 Apr 13.

10.

Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.

Vajjhala PR, Mirams RE, Hill JM.

J Biol Chem. 2012 Dec 7;287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12.

11.

Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1.

Poyet JL, Srinivasula SM, Tnani M, Razmara M, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2001 Jul 27;276(30):28309-13. Epub 2001 Jun 4.

12.

Pyrin N-terminal homology domain- and caspase recruitment domain-dependent oligomerization of ASC.

Masumoto J, Taniguchi S, Sagara J.

Biochem Biophys Res Commun. 2001 Jan 26;280(3):652-5.

PMID:
11162571
13.

Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.

Dowds TA, Masumoto J, Zhu L, Inohara N, Núñez G.

J Biol Chem. 2004 May 21;279(21):21924-8. Epub 2004 Mar 12.

14.

Inhibiting the inflammasome: one domain at a time.

Dorfleutner A, Chu L, Stehlik C.

Immunol Rev. 2015 May;265(1):205-16. doi: 10.1111/imr.12290. Review.

15.

CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.

Razmara M, Srinivasula SM, Wang L, Poyet JL, Geddes BJ, DiStefano PS, Bertin J, Alnemri ES.

J Biol Chem. 2002 Apr 19;277(16):13952-8. Epub 2002 Jan 30.

16.

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7. Epub 2006 Jun 19.

17.

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH.

Cell. 2014 Mar 13;156(6):1193-206. doi: 10.1016/j.cell.2014.02.008.

18.

The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation.

Stehlik C, Krajewska M, Welsh K, Krajewski S, Godzik A, Reed JC.

Biochem J. 2003 Jul 1;373(Pt 1):101-13.

19.

Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis.

Chae JJ, Komarow HD, Cheng J, Wood G, Raben N, Liu PP, Kastner DL.

Mol Cell. 2003 Mar;11(3):591-604.

20.

Overexpressed NLRC3 acts as an anti-inflammatory cytosolic protein.

Gültekin Y, Eren E, Özören N.

J Innate Immun. 2015;7(1):25-36. doi: 10.1159/000363602. Epub 2014 Sep 27.

PMID:
25277106

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