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Genomic instability in mice lacking histone H2AX.

Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, Tessarollo L, Livak F, Manova K, Bonner WM, Nussenzweig MC, Nussenzweig A.

Science. 2002 May 3;296(5569):922-7. Epub 2002 Apr 4.


AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching.

Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsuk M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, Nussenzweig A.

Nature. 2001 Dec 6;414(6864):660-665. doi: 10.1038/414660a.


UV and genotoxic stress induce ATR relocalization in mouse spermatocytes.

Di Siena S, Campolo F, Rossi P, Jannini EA, Dolci S, Pellegrini M.

Int J Dev Biol. 2013;57(2-4):281-7. doi: 10.1387/ijdb.130039sd.


Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.

Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A.

Nat Cell Biol. 2003 Jul;5(7):675-9.


Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.

Sonoda E, Zhao GY, Kohzaki M, Dhar PK, Kikuchi K, Redon C, Pilch DR, Bonner WM, Nakano A, Watanabe M, Nakayama T, Takeda S, Takami Y.

DNA Repair (Amst). 2007 Mar 1;6(3):280-92. Epub 2006 Nov 22.


DNA double-strand breaks and gamma-H2AX signaling in the testis.

Hamer G, Roepers-Gajadien HL, van Duyn-Goedhart A, Gademan IS, Kal HB, van Buul PP, de Rooij DG.

Biol Reprod. 2003 Feb;68(2):628-34.


Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1.

Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG.

DNA Repair (Amst). 2007 Sep 1;6(9):1243-54. Epub 2007 Mar 21.


BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.

Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K.

PLoS Genet. 2010 Jan 22;6(1):e1000826. doi: 10.1371/journal.pgen.1000826.


H2AX: the histone guardian of the genome.

Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):959-67. Review.


Regulation of DNA end joining, resection, and immunoglobulin class switch recombination by 53BP1.

Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2011 May 6;42(3):319-29. doi: 10.1016/j.molcel.2011.03.019.


A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM.

Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95.


Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.

Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A.

J Exp Med. 2010 May 10;207(5):973-81. doi: 10.1084/jem.20092308. Epub 2010 Apr 12.


H2AX haploinsufficiency modifies genomic stability and tumor susceptibility.

Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A.

Cell. 2003 Aug 8;114(3):371-383.


Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.

Orsburn B, Escudero B, Prakash M, Gesheva S, Liu G, Huso DL, Franco S.

Mol Cell Biol. 2010 May;30(10):2341-52. doi: 10.1128/MCB.00091-10. Epub 2010 Mar 15.


Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.

Bassing CH, Chua KF, Sekiguchi J, Suh H, Whitlow SR, Fleming JC, Monroe BC, Ciccone DN, Yan C, Vlasakova K, Livingston DM, Ferguson DO, Scully R, Alt FW.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8173-8. Epub 2002 May 28.


Histone H2A phosphorylation controls Crb2 recruitment at DNA breaks, maintains checkpoint arrest, and influences DNA repair in fission yeast.

Nakamura TM, Du LL, Redon C, Russell P.

Mol Cell Biol. 2004 Jul;24(14):6215-30. Erratum in: Mol Cell Biol. 2004 Sep;24(17):7820.


Characteristics of gamma-H2AX foci at DNA double-strand breaks sites.

Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM.

Biochem Cell Biol. 2003 Jun;81(3):123-9. Review.


H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.

Mol Cell. 2006 Jan 20;21(2):201-14.


Acetylation of Histone H2AX at Lys 5 by the TIP60 Histone Acetyltransferase Complex Is Essential for the Dynamic Binding of NBS1 to Damaged Chromatin.

Ikura M, Furuya K, Matsuda S, Matsuda R, Shima H, Adachi J, Matsuda T, Shiraki T, Ikura T.

Mol Cell Biol. 2015 Dec;35(24):4147-57. doi: 10.1128/MCB.00757-15. Epub 2015 Oct 5.


Characterization of Spo11-dependent and independent phospho-H2AX foci during meiotic prophase I in the male mouse.

Chicheportiche A, Bernardino-Sgherri J, de Massy B, Dutrillaux B.

J Cell Sci. 2007 May 15;120(Pt 10):1733-42. Epub 2007 Apr 24.

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