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Items: 1 to 20 of 112


Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression.

Ku NO, Michie S, Resurreccion EZ, Broome RL, Omary MB.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4373-8. Epub 2002 Mar 26.


Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice.

Ku NO, Michie SA, Soetikno RM, Resurreccion EZ, Broome RL, Omary MB.

J Cell Biol. 1998 Dec 28;143(7):2023-32.


Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation.

Harada M, Strnad P, Resurreccion EZ, Ku NO, Omary MB.

Hepatology. 2007 Jan;45(1):88-96.


Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity.

Weerasinghe SV, Ku NO, Altshuler PJ, Kwan R, Omary MB.

J Cell Sci. 2014 Apr 1;127(Pt 7):1464-75. doi: 10.1242/jcs.138479. Epub 2014 Jan 24.


Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima RG, Baribault H, Omary MB.

Am J Pathol. 2008 Apr;172(4):882-92. doi: 10.2353/ajpath.2008.070830. Epub 2008 Mar 18.


Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.

Snider NT, Weerasinghe SV, Iñiguez-Lluhí JA, Herrmann H, Omary MB.

J Biol Chem. 2011 Jan 21;286(3):2273-84. doi: 10.1074/jbc.M110.171314. Epub 2010 Nov 9.


Susceptibility to hepatotoxicity in transgenic mice that express a dominant-negative human keratin 18 mutant.

Ku NO, Michie SA, Soetikno RM, Resurreccion EZ, Broome RL, Oshima RG, Omary MB.

J Clin Invest. 1996 Aug 15;98(4):1034-46.


PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding.

Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Conti MA, Adelstein RS, Xie Q, Omary MB.

Hepatology. 2015 Dec;62(6):1858-69. doi: 10.1002/hep.27965. Epub 2015 Aug 25.


Cytoskeletal keratin glycosylation protects epithelial tissue from injury.

Ku NO, Toivola DM, Strnad P, Omary MB.

Nat Cell Biol. 2010 Sep;12(9):876-85. doi: 10.1038/ncb2091. Epub 2010 Aug 22.


Functional Implications of O-GlcNAcylation-dependent Phosphorylation at a Proximal Site on Keratin 18.

Kakade PS, Budnar S, Kalraiya RD, Vaidya MM.

J Biol Chem. 2016 Jun 3;291(23):12003-13. doi: 10.1074/jbc.M116.728717. Epub 2016 Apr 8.


Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.

Ku NO, Strnad P, Zhong BH, Tao GZ, Omary MB.

Hepatology. 2007 Nov;46(5):1639-49. Review.


Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury.

Tao GZ, Toivola DM, Zhong B, Michie SA, Resurreccion EZ, Tamai Y, Taketo MM, Omary MB.

J Cell Sci. 2003 Nov 15;116(Pt 22):4629-38.


Keratin 20 helps maintain intermediate filament organization in intestinal epithelia.

Zhou Q, Toivola DM, Feng N, Greenberg HB, Franke WW, Omary MB.

Mol Biol Cell. 2003 Jul;14(7):2959-71. Epub 2003 Apr 4.

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