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Items: 1 to 20 of 226


Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies.

Surinya KH, Molina L, Soos MA, Brandt J, Kristensen C, Siddle K.

J Biol Chem. 2002 May 10;277(19):16718-25.


Dimeric fragment of the insulin receptor alpha-subunit binds insulin with full holoreceptor affinity.

Brandt J, Andersen AS, Kristensen C.

J Biol Chem. 2001 Apr 13;276(15):12378-84.


Structural domains of the insulin receptor and IGF receptor required for dimerisation and ligand binding.

Molina L, Marino-Buslje C, Quinn DR, Siddle K.

FEBS Lett. 2000 Feb 11;467(2-3):226-30.


Characterization of a second ligand binding site of the insulin receptor.

Hao C, Whittaker L, Whittaker J.

Biochem Biophys Res Commun. 2006 Aug 18;347(1):334-9.


Structural insights into ligand-induced activation of the insulin receptor.

Ward C, Lawrence M, Streltsov V, Garrett T, McKern N, Lou MZ, Lovrecz G, Adams T.

Acta Physiol (Oxf). 2008 Jan;192(1):3-9. doi: 10.1111/j.1748-1716.2007.01781.x. Review.


Structure of the insulin receptor ectodomain reveals a folded-over conformation.

McKern NM, Lawrence MC, Streltsov VA, Lou MZ, Adams TE, Lovrecz GO, Elleman TC, Richards KM, Bentley JD, Pilling PA, Hoyne PA, Cartledge KA, Pham TM, Lewis JL, Sankovich SE, Stoichevska V, Da Silva E, Robinson CP, Frenkel MJ, Sparrow LG, Fernley RT, Epa VC, Ward CW.

Nature. 2006 Sep 14;443(7108):218-21.


Comparison of the functional insulin binding epitopes of the A and B isoforms of the insulin receptor.

Whittaker J, Sørensen H, Gadsbøll VL, Hinrichsen J.

J Biol Chem. 2002 Dec 6;277(49):47380-4.


Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers.

Stortelers C, van De Poll ML, Lenferink AE, Gadellaa MM, van Zoelen C, van Zoelen EJ.

Biochemistry. 2002 Apr 2;41(13):4292-301.


Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site.

Whittaker J, Groth AV, Mynarcik DC, Pluzek L, Gadsbøll VL, Whittaker LJ.

J Biol Chem. 2001 Nov 23;276(47):43980-6.


Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.

Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A.

J Biol Chem. 2002 Oct 18;277(42):39684-95.


An investigation of the ligand binding properties and negative cooperativity of soluble insulin-like growth factor receptors.

Surinya KH, Forbes BE, Occhiodoro F, Booker GW, Francis GL, Siddle K, Wallace JC, Cosgrove LJ.

J Biol Chem. 2008 Feb 29;283(9):5355-63.


Mapping of the insulin-like growth factor II binding site of the Type I insulin-like growth factor receptor by alanine scanning mutagenesis.

Sørensen H, Whittaker L, Hinrichsen J, Groth A, Whittaker J.

FEBS Lett. 2004 May 7;565(1-3):19-22.


The position of the alpha and beta subunits in a single chain variant of human chorionic gonadotropin affects the heterodimeric interaction of the subunits and receptor-binding epitopes.

Ben-Menahem D, Jablonka-Shariff A, Hyde RK, Pixley MR, Srivastava S, Berger P, Boime I.

J Biol Chem. 2001 Aug 10;276(32):29871-9.

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