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Items: 1 to 20 of 183


BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes.

Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H, Pellegrini M, Cory S, Adams JM, Strasser A.

Nature. 2002 Feb 21;415(6874):922-6. Erratum in: Nature 2002 Jul 4;618(6893):108.


Ligation of retinoic acid receptor alpha regulates negative selection of thymocytes by inhibiting both DNA binding of nur77 and synthesis of bim.

Szegezdi E, Kiss I, Simon A, Blaskó B, Reichert U, Michel S, Sándor M, Fésüs L, Szondy Z.

J Immunol. 2003 Apr 1;170(7):3577-84.


Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes.

Bunin A, Khwaja FW, Kersh GJ.

J Immunol. 2005 Aug 1;175(3):1532-9.


Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells.

Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A.

J Exp Med. 2003 Oct 6;198(7):1119-26.


Differential roles for Bim and Nur77 in thymocyte clonal deletion induced by ubiquitous self-antigen.

Hu QN, Baldwin TA.

J Immunol. 2015 Mar 15;194(6):2643-53. doi: 10.4049/jimmunol.1400030.


The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens.

Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P, Strasser A.

Immunity. 2012 Sep 21;37(3):451-62. doi: 10.1016/j.immuni.2012.05.030.


The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus.

Tao W, Teh SJ, Melhado I, Jirik F, Korsmeyer SJ, Teh HS.

J Exp Med. 1994 Jan 1;179(1):145-53.


Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling.

Villunger A, Marsden VS, Zhan Y, Erlacher M, Lew AM, Bouillet P, Berzins S, Godfrey DI, Heath WR, Strasser A.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7052-7.


Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene.

Strasser A, Harris AW, von Boehmer H, Cory S.

Proc Natl Acad Sci U S A. 1994 Feb 15;91(4):1376-80.


Regulation of expression of Bcl-2 protein family member Bim by T cell receptor triggering.

Sandalova E, Wei CH, Masucci MG, Levitsky V.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3011-6.


A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway.

Kovalovsky D, Pezzano M, Ortiz BD, Sant'Angelo DB.

PLoS One. 2010 Jan 13;5(1):e8675. doi: 10.1371/journal.pone.0008675.


Apoptosis during negative selection of autoreactive thymocytes.

Sohn SJ, Thompson J, Winoto A.

Curr Opin Immunol. 2007 Oct;19(5):510-5. Review.


Con A activates an Akt/PKB dependent survival mechanism to modulate TCR induced cell death in double positive thymocytes.

Pongracz J, Parnell S, Anderson G, Jaffrézou JP, Jenkinson E.

Mol Immunol. 2003 Jun;39(16):1013-23.


Proapoptotic protein Bim is differentially required during thymic clonal deletion to ubiquitous versus tissue-restricted antigens.

Suen AY, Baldwin TA.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):893-8. doi: 10.1073/pnas.1114834109.


Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim.

Davey GM, Kurts C, Miller JF, Bouillet P, Strasser A, Brooks AG, Carbone FR, Heath WR.

J Exp Med. 2002 Oct 7;196(7):947-55.


Bim: a novel member of the Bcl-2 family that promotes apoptosis.

O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC.

EMBO J. 1998 Jan 15;17(2):384-95.


Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice.

Tischner D, Gaggl I, Peschel I, Kaufmann M, Tuzlak S, Drach M, Thuille N, Villunger A, Jan Wiegers G.

J Autoimmun. 2012 Feb;38(1):59-69. doi: 10.1016/j.jaut.2011.12.008.

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