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Items: 1 to 20 of 198


Differential interactions of nucleotides at the two nucleotide binding domains of the cystic fibrosis transmembrane conductance regulator.

Aleksandrov L, Mengos A, Chang X, Aleksandrov A, Riordan JR.

J Biol Chem. 2001 Apr 20;276(16):12918-23. Epub 2001 Jan 29.


Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis.

Ikuma M, Welsh MJ.

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8675-80.


Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog.

Bompadre SG, Li M, Hwang TC.

J Biol Chem. 2008 Feb 29;283(9):5364-9. doi: 10.1074/jbc.M709417200. Epub 2007 Dec 30.


Nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator, an ABC transporter, catalyze adenylate kinase activity but not ATP hydrolysis.

Gross CH, Abdul-Manan N, Fulghum J, Lippke J, Liu X, Prabhakar P, Brennan D, Willis MS, Faerman C, Connelly P, Raybuck S, Moore J.

J Biol Chem. 2006 Feb 17;281(7):4058-68. Epub 2005 Dec 16.


The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics.

Zhou Z, Wang X, Liu HY, Zou X, Li M, Hwang TC.

J Gen Physiol. 2006 Oct;128(4):413-22. Epub 2006 Sep 11.


ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

Wang W, Wu J, Bernard K, Li G, Wang G, Bevensee MO, Kirk KL.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3888-93. doi: 10.1073/pnas.0913001107. Epub 2010 Feb 3.


Regulation by ATP and ADP of CFTR chloride channels that contain mutant nucleotide-binding domains.

Anderson MP, Welsh MJ.

Science. 1992 Sep 18;257(5077):1701-4. Erratum in: Science 1992 Dec 11;258(5089):1719.


Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain.

Howell LD, Borchardt R, Kole J, Kaz AM, Randak C, Cohn JA.

Biochem J. 2004 Feb 15;378(Pt 1):151-9.


Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel.

Tsai MF, Li M, Hwang TC.

J Gen Physiol. 2010 May;135(5):399-414. doi: 10.1085/jgp.201010399.


Structure and function of the CFTR chloride channel.

Sheppard DN, Welsh MJ.

Physiol Rev. 1999 Jan;79(1 Suppl):S23-45. Review.


G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defects.

Bompadre SG, Sohma Y, Li M, Hwang TC.

J Gen Physiol. 2007 Apr;129(4):285-98. Epub 2007 Mar 12.


Nucleotide binding domains of human CFTR: a structural classification of critical residues and disease-causing mutations.

Eudes R, Lehn P, FĂ©rec C, Mornon JP, Callebaut I.

Cell Mol Life Sci. 2005 Sep;62(18):2112-23.


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